Results 71 to 80 of about 1,038 (200)

A novel quality by design approach for developing an HPLC method to analyze herbal extracts: A case study of sugar content analysis.

PLoS ONE, 2018
The aim of this study was to present a novel analytical quality by design (AQbD) approach for developing an HPLC method to analyze herbal extracts.
Jingyuan Shao, Wen Cao, Haibin Qu, Jianyang Pan, Xingchu Gong   +4 more
doaj   +1 more source

Deduction of the operable design space of RP-HPLC technique for the simultaneous estimation of metformin, pioglitazone, and glimepiride

Scientific Reports, 2023
A reversed-phase RP-HPLC method was developed for the simultaneous determination of metformin hydrochloride (MET), pioglitazone (PIO), and glimepiride (GLM) in their combined dosage forms and spiked human plasma.
Aya A. Marie, Sherin F. Hammad, Mohamed M. Salim, Mahmoud M. Elkhodary, Amira H. Kamal   +4 more
doaj   +1 more source

AQbD-novel strategy for analytical methods

Future Journal of Pharmaceutical Sciences
Background Analytical Quality by Design (AQbD) has emerged as a pivotal paradigm in the realm of analytical chemistry, revolutionizing the approach to method development and validation. This innovative strategy integrates principles of Quality by Design (
Amruta Bairagi, Rutuja Kothrukar, Hemant Chikhale, Sreya Kosanam, Laxmikant Borse   +4 more
doaj   +1 more source

Box–Behnken design-assisted optimization of RP-HPLC method for the estimation of evogliptin tartrate by analytical quality by design

Future Journal of Pharmaceutical Sciences, 2023
Background A quality by design approach can potentially lead to a more robust/rugged method development due to emphasis on the risk assessment and management.
Khushbu Patel, Ujashkumar A. Shah, C. N. Patel   +2 more
doaj   +1 more source

Sustainable Ethanol‐Based Reversed‐Phase Liquid Chromatography for Determination of Diltiazem pKa and Quantification with Integrated Green and White Analytical Metrics

ChemistryOpen, Volume 15, Issue 5, May 2026.
A sustainable reversed‐phase liquid chromatography method is developed for diltiazem analysis and pKadetermination. The study integrates green and white analytical chemistry frameworks to evaluate environmental impact and practicality. The Environmental, Performance, and Practicality Index is utilized as a comprehensive, holistic tool for the ...
Zehra Üstün, İlkay Konçe, Ebru Çubuk Demiralay   +2 more
wiley   +1 more source

Analytical Quality by Design approach in the development of a green reversed-phase ultra-high performance liquid chromatography/high-resolution time-of-flight mass spectrometry method for the simultaneous analysis of synthetic antimicrobial and hypotensive peptides

Journal of Chromatography Open
The growing therapeutic interest in peptides from Tityus stigmurus scorpion venom and their analogues highlights the need for the development of robust analytical methods for these compounds.
Ana Roberta Pereira Johnson dos Anjos, Márcia Natália da Silveira Pinto, Dayanne Lopes Porto, Fabio Santos de Souza, Rui Oliveira Macedo, Matheus de Freitas Fernandes Pedrosa, Cícero Flávio Soares Aragão   +6 more
doaj   +1 more source

Analytical quality by design assisted RP-HPLC method for quantifying atorvastatin with green analytical chemistry perspective

Journal of Chromatography Open, 2022
Analytical Quality by design and greener solvent methods were applied to optimize the High-Performance Liquid Chromatographic method for assessing atorvastatin calcium in bulk and pharmaceutical dosage forms are highlighted in the present work.
K.S. Kokilambigai, K.S. Lakshmi
doaj   +1 more source

Implementation of Quality by Design (QbD) approach to the analytical method development and validation for the estimation of Remogliflozin Etabonate in tablet dosage form by HPLC [PDF]

Analytical Quality by Design is a recent concept related to the development and validation of the analytical procedures (AQbD). This is done in analytical QbD by defining quality targets which enable the performance of the analytical procedure within the
Yash M. Phulwani, Shankar S. Yelmame, Laxmikant B. Borse
core   +2 more sources

Sustainable RP‐HPLC Approach for Profiling Pioglitazone and Related Substances

Journal of Chemistry, Volume 2026, Issue 1, 2026.
A sustainable RP‐HPLC method for the comprehensive fingerprinting of pioglitazone and its related substances was developed and validated in alignment with green analytical chemistry principles. Utilizing eco‐friendly solvents and reducing waste generation were used to optimize chromatographic conditions.
Tahani Y. A. Alanazi, Samar M. Mahgoub, Fahad M. Alminderej, Yasmeen G. Abou El-Reash, Omkulthom Al kamaly, Sayed M. Saleh, Mahmoud A. Mohamed, Munmun Bardhan   +7 more
wiley   +1 more source

Development and Validation of a Novel Isocratic RP-HPLC Method Using AQbD Approach for the Quantification of Favipiravir [PDF]

Background/Objectives: In this study, the analytical quality by design (AQbD) approach was used to develop an eco-friendly reversed-phase high-performance liquid chromatography (RP–HPLC) method to identify and quantify favipiravir (FAV).
Balogh György Tibor, Katona Gábor, Pannonhalminé Csóka Ildikó, Salamah Maryana, Sipos Bence, Volk Balázs   +5 more
core   +1 more source