Results 71 to 80 of about 299 (155)

Central composite design (CCD) approach to develop HPLC method for caffeine: Application to coffee samples analysis of Jazan region, Saudi Arabia

Journal of Saudi Chemical Society
The goal of this study was to use High performance liquid chromatography (HPLC) with an Analytical Quality by Design (AQbD) approach to measure the amount of caffeine in selected coffee samples available in the local Jazan market in Saudi Arabia.
Asim Najmi, Zia ur Rehman, Khalid Zoghebi, Hassan Ahmed Alhazmi, Mohammed Mofarreh Albratty, Qasem Yahya Hassan Haroobi, Ismail Mohammed Ali Sayram, Mohammed Ahmed Saleh, Waleed Mohammed Ahmed Qaser, Abdulaziz Ali Houssein Qaysi   +9 more
doaj   +1 more source

Application of Analytical Quality by Design (AQbD) in Developing Robust Methods for Herbicide Analysis-A Case Study on Metribuzin

International Journal of Pharmaceutical Research and Applications
Analytical Quality by Design (AQbD) applies Quality by Design principles to analytical method development, aiming to design methods that are robust, well-understood, and life cycle managed. Herbicide residue analysis (monitoring active compounds and metabolites in formulations, food, soil, and water) presents challenges of trace-level detection, matrix
Wafa T Wafa T, Shifa Mammed Kutty K M, Saranya Mohan, Najah P A Meena P V   +3 more
openaire   +1 more source

Implementation of Analytical Quality by Design (AQbD) approach to RP-HPLC method for dissolution testing

, 2015
Quality by Design (QbD) principles were implemented in RP-HPLC method development for the analysis of dissolution samples of immediate release film-coated tablets. Critical method variables and critical method attributes were identified. After the initial risk assessment, a DoE (design of experiments) study was performed to investigate the impact of ...
Pranjić, Josip, Radošević, Senka, Lusina Kregar, Maja   +2 more
openaire   +2 more sources

AQbD-guided stability indicating HPLC method for azelnidipine and chlorthalidone fixed-dose combination tablet: a green approach

Journal of Taibah University for Science
This study developed a stability-indicating RP-HPLC method for quantifying azelnidipine and chlorthalidone in fixed-dose formulations using Analytical Quality by Design (AQbD) principles.
Rajvi Agrawal, Rajendra Kotadiya
doaj   +1 more source

Application of the concept of design space in method development for the determination of contaminants in soil [PDF]

Proceedings of the Estonian Academy of Sciences
The analysis of polycyclic aromatic hydrocarbons and polychlorinated biphenyls is an important topic in environmental analysis, and several analysis procedures have already been proposed.
Jelena Jurjeva, Mihkel Koel
doaj   +1 more source

Analytical Quality by Design (AQbD): Principles, Tools and Case Studies

Quality by Design is a systematic approach used in pharmaceutical development that builds product quality into the formulation and manufacturing processes from the outset. Although its adoption is increasing within the generic drug industry, many professionals are still not deeply familiar with its principles or terminology.
openaire   +1 more source

International Approaches to the Development, Validation, and Change Management of Analytical Procedures (Review)

Регуляторные исследования и экспертиза лекарственных средств
INTRODUCTION. In 2023, the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) published a new Guideline on Analytical Procedure Development (ICH Q14) and a revised version of the Guideline on ...
A. V. Fetisova, Zh. I. Aladysheva, N. V. Pyatigorskaya, O. A. Zyryanov, M. M. Marshalova   +4 more
doaj   +1 more source

Analytical Quality by Design (AQbD): A Contemporary Framework for Pharmaceutical Analytical Development

Analytical Quality by Design (AQbD) is a systematic, science- and risk-based approach for developing robust, reliable, and regulatory-compliant analytical methods in the pharmaceutical industry. Unlike traditional trial-and-error approaches, AQbD builds quality into the method from the beginning through predefined objectives, scientific understanding ...
openaire   +1 more source

ANALYTICAL QUALITY BY DESIGN (AQBD) APPROACH FOR LIFECYCLE MANAGEMENT OF PHARMACEUTICAL ANALYTICAL METHODS

The pharmaceutical industry has increasingly adopted science- and risk-based approaches to ensure the quality, safety, and efficacy of pharmaceutical products. One of the most widely implemented strategies is Quality by Design (QbD), which emphasises systematic product and process understanding during drug development.
openaire   +1 more source

A comprehensive RP-HPLC technique for analyzing disodium edetate and its degradation products in eye drops using AQbD and Six Sigma perspective

Reviews in Analytical Chemistry
The study presents the development of a novel, sustainable, and analytical quality by design (AQbD) driven RP-HPLC method to simultaneously identify disodium edetate in eye drops and its degradation products.
Alanazi Tahani Y. A., Alluhayb Abdullah H., Alsehli Bandar R., Binsaleh Ammena Y., Saleh Sayed M., Mohamed Mahmoud A.   +5 more
doaj   +1 more source