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Convergent parallel mixed-methods study to understand the impact of decision-making for congenital cardiac surgery patients at a tertiary paediatric hospital: a study protocol. [PDF]

BMJ Open
Yin L, Pinkney S, Assadi A, Fan M, Zahiri Y, Mazwi M, Honjo O, Trbovich P.   +7 more
europepmc   +1 more source

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Comparable HIV suppression by pegylated-IFN-α2a or pegylated-IFN-α2b during a 4-week analytical treatment interruption

AIDS, 2021
We report on the post-hoc analysis of three clinical studies (NCT01935089, NCT00594880 and NCT00051818) with chronically HIV-infected, immune-reconstituted individuals with similar entry criteria, and demographics interrupting antiretroviral therapy (ART) without or with 5 weeks of weekly pegylated (Peg)-IFN-α2b or Peg-IFN-α2a
Emmanouil, Papasavvas, Livio, Azzoni, Brian N, Ross, Matthew, Fair, Bonnie J, Howell, Daria J, Hazuda, Karam, Mounzer, Jay R, Kostman, Pablo, Tebas, Luis J, Montaner   +9 more
openaire   +2 more sources

Impact of analytical treatment interruption on the central nervous system in a simian-HIV model

AIDS, 2019
Analytical treatment interruption (ATI) studies are often used to evaluate potential HIV cure strategies. This study was conducted to determine the impact of ATI on simian-HIV (SHIV) infection in the central nervous system.Animal study.Nine rhesus macaques were inoculated with SHIV-1157ipd3N4.
Denise C, Hsu, Decha, Silsorn, Dutsadee, Inthawong, Yanin, Kuncharin, Jumpol, Sopanaporn, Rawiwan, Im-Erbsin, Kesara, Chumpolkulwong, Robert J, O'connell, Nelson L, Michael, Christine A, Ege, Sandhya, Vasan   +10 more
openaire   +2 more sources

A Collaboratory, Multi-Disciplinary Approach to Risk Mitigation during HIV Analytical Treatment Interruption

2020
Analytic treatment interruptions (ATIs) are currently the standard for assessing the impact of experimental interventions aimed at inducing sustained antiretroviral therapy (ART)-free remission in trials related to HIV cure. ATIs are associated with substantial risk to both study participants and their sexual partner(s).
Dee, L., Rutishauser, R. L., Taylor, J., Deeks, S. G., Campbell, D., Peluso, M. J., Sauceda, J., Dubé, K., Hoh, R.   +8 more
openaire   +1 more source

Analytical treatment interruption in children living with HIV: position statement from the EPIICAL consortium

The Lancet HIV
Analytical treatment interruption (ATI) is widely acknowledged as an essential component of studies to advance our understanding of HIV cure, but discussion has largely been focused on adults. To address this gap, we reviewed evidence related to the safety and utility of ATI in paediatric populations.
Kuhn, Louise, Barnabas, Shaun, Cotugno, Nicola, Peay, Holly, Goulder, Philip, Cotton, Mark, Violari, Avy, Pahwa, Savita, Reddy, Kavidha, Tagarro, Alfredo, Otwombe, Kennedy, Fry, Samantha, Vaz, Paula, Lain, Maria Grazia, Nhampossa, Tacilta, Archary, Moherndran, Maiga, Almoustapha Issiaka, Puthanakit, Thanyawee, Kityo, Cissy M, Foster, Caroline, Rojo, Pablo, Klein, Nigel, Nastouli, Eleni, Tiemessen, Caroline T, de Rossi, Anita, Ndung'u, Thumbi, Persaud, Deborah, Lichterfeld, Mathias, Giaquinto, Carlo, Palma, Paolo, Rossi, Paolo   +30 more
openaire   +3 more sources

Factors Influencing Virologic Control During Analytical Treatment Interruptions in HIV Cure Trials—a Pooled Analysis of Individual-Level Data

The Journal of Infectious Diseases
Abstract Background Achieving antiretroviral therapy (ART)-free virologic control remains a central goal in human immunodeficiency virus (HIV) cure research. To identify factors associated with time to detectable viremia and time to loss of virologic control, we conducted a pooled analysis of 6 ...
Vibeke Klastrup, Jesper Damsgaard Gunst, Thomas Aagaard Rasmussen, Martin Tolstrup, Ole Schmeltz Søgaard   +4 more
openaire   +2 more sources

Analytical Treatment Interruption in HIV-infected Individuals: Clinical Perspectives

Future Virology, 2018
Katherine Clarridge, Tae-Wook Chun
openaire   +1 more source

Please wait until I am done! Longitudinal effects of work interruptions on employee well-being

Work and Stress, 2020
Anita C Keller, Laurenz L Meier, Achim Elfering   +2 more
exaly  

Self-interruptions in discretionary multitasking

Computers in Human Behavior, 2013
Rachel F Adler, Raquel Benbunan-Fich
exaly  

Interruptions and Pediatric Patient Safety

Journal of Pediatric Nursing, 2010
Linda McGillis Hall
exaly