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Ethics of HIV cure research: an unfinished agenda [PDF]

BMC Medical Ethics, 2021
Background The pursuit of a cure for HIV is a high priority for researchers, funding agencies, governments and people living with HIV (PLWH). To date, over 250 biomedical studies worldwide are or have been related to discovering a safe, effective, and ...
Karine Dubé, John Kanazawa, Jeff Taylor, Lynda Dee, Nora Jones, Christopher Roebuck, Laurie Sylla, Michael Louella, Jan Kosmyna, David Kelly, Orbit Clanton, David Palm, Danielle M. Campbell, Morénike Giwa Onaiwu, Hursch Patel, Samuel Ndukwe, Laney Henley, Mallory O. Johnson, Parya Saberi, Brandon Brown, John A. Sauceda, Jeremy Sugarman   +21 more
doaj   +7 more sources

Perceptions of HIV cure research among people living with HIV in Australia. [PDF]

PLoS ONE, 2018
Participation in HIV cure-related clinical trials that involve antiretroviral treatment (ART) interruption may pose substantial individual risks for people living with HIV (PLHIV) without any therapeutic benefit.
Jennifer Power, Andrew Westle, Gary W Dowsett, Jayne Lucke, Joseph D Tucker, Jeremy Sugarman, Sharon R Lewin, Sophie Hill, Graham Brown, Jack Wallace, Jacqui Richmond   +10 more
doaj   +6 more sources

Emerging PCR-Based Techniques to Study HIV-1 Reservoir Persistence [PDF]

Viruses, 2020
While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Laurens Lambrechts, Basiel Cole, Sofie Rutsaert, Wim Trypsteen, Linos Vandekerckhove   +4 more
doaj   +3 more sources

HIV cure research: print and online media reporting in Australia [PDF]

Journal of Virus Eradication, 2017
Objectives: While still in its early stages, recent scientific research towards a cure for HIV has generated widespread media interest. The aim of this paper was to explore the ways in which this research has been represented in Australian print and ...
Jennifer Power, Bianca Fileborn, Gary W. Dowsett, Jayne Lucke, Graham Brown, Jeanne Ellard, Sharon R. Lewin, Joseph D. Tucker, Sean Slavin, Jeremy Sugarman, Sophie Hill   +10 more
doaj   +5 more sources

Digital PCR as a tool to measure HIV persistence [PDF]

Retrovirology, 2018
Although antiretroviral therapy is able to suppress HIV replication in infected patients, the virus persists and rebounds when treatment is stopped.
Sofie Rutsaert, Kobus Bosman, Wim Trypsteen, Monique Nijhuis, Linos Vandekerckhove   +4 more
doaj   +3 more sources

Highlights from the HIV Cure and Reservoir Symposium, 11–12 September 2017, Ghent, Belgium [PDF]

Journal of Virus Eradication, 2018
For the second time, the HIV Cure Research Center (HCRC) at Ghent University organised the HIV Cure and Reservoir Symposium, in Ghent, Belgium, where in this two-day conference, virologists, molecular biologists, immunologists and clinicians presented ...
Sam Kint, Clarissa Van Hecke, Basiel Cole, Linos Vandekerckhove, Magdalena Sips   +4 more
doaj   +3 more sources

Understanding of HIV cure research in a rural community with high prevalence: the case of uMkhanyakude district, KwaZulu-Natal, South Africa [PDF]

AIDS Research and Therapy
Background Curing HIV has become a scientific priority with the development of HIV cure-related research collaborations and increasing clinical efforts.
Rujeko Samanthia Chimukuche, Miliswa Magongo, Qinisile Shandu, Ingrid V. Bassett, Thumbi Ndung’u, Janet Seeley   +5 more
doaj   +2 more sources

The significance and expectations of HIV cure research among people living with HIV in Australia. [PDF]

PLoS ONE, 2020
Most people living with HIV (PLHIV) with reliable access to antiretroviral treatment (ART) have a life expectancy similar to uninfected populations. Despite this, HIV can negatively affect their social and psychological wellbeing.
Jennifer Power, Gary W Dowsett, Andrew Westle, Joseph D Tucker, Sophie Hill, Jeremy Sugarman, Sharon R Lewin, Graham Brown, Jayne Lucke   +8 more
doaj   +2 more sources

Participation in HIV cure-related research: a scoping review of the proxy literature and implications for future research

Journal of Virus Eradication, 2015
Objective: To identify the main types of HIV cure-related strategies and examine possible risks (and benefits) associated with participating in HIV cure-related research studies.
Karine Dubé, Catalina Ramirez, Jessica Handibode, Jeffrey Taylor, Asheley Skinner, Sandra Greene, Joseph D. Tucker   +6 more
doaj   +3 more sources

Willingness to risk death endpoint in HIV cure-related research with otherwise healthy volunteers is misleading

Journal of Virus Eradication, 2020
This viewpoint article critiques two recent articles examining ‘willingness to risk death’ to advance HIV cure-related research. The ‘willingness to risk death’ endpoint sends the wrong signal to the HIV cure-related research community about ongoing ...
Karine Dubé, Lynda Dee
doaj   +3 more sources