Results 21 to 30 of about 138,358 (278)

The Contributions of Clinical Pharmacology to HIV Cure Research. [PDF]

Clin Pharmacol Ther, 2021
Combination antiretroviral therapy (ART) can suppress plasma HIV‐RNA to < 50 copies/mL, decrease HIV transmission, reduce mortality, and improve quality of life for people living with HIV. ART cannot, however, eliminate HIV from an infected individual.
Fletcher CV, Dyavar SR, Acharya A, Byrareddy SN.   +3 more
europepmc   +3 more sources

Controversies in HIV cure research [PDF]

Journal of the International AIDS Society, 2012
BackgroundAntiretroviral therapy significantly reduces HIV viral burden and prolongs life, but does not cure HIV infection. The major scientific barrier to a cure is thought to be the persistence of the virus in cellular and/or anatomical reservoirs.DiscussionMost efforts to date, including pharmaco, immuno or gene therapy, have failed to cure patients,
Johnston, Rowena, Barré-Sinoussi, Françoise   +1 more
openaire   +2 more sources

Applying the Behavioural and Social Sciences Research (BSSR) Functional Framework to HIV Cure Research. [PDF]

J Int AIDS Soc, 2019
Dubé K, Auerbach JD, Stirratt MJ, Gaist P.   +3 more
europepmc   +2 more sources

Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons

mBio, 2022
Coronavirus disease 2019 (COVID-19) is frequently associated with neurological deficits, but how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces these effects remains unclear.
Weili Kong, Mauricio Montano, Michael J. Corley, Ekram Helmy, Hirofumi Kobayashi, Martin Kinisu, Rahul Suryawanshi, Xiaoyu Luo, Loic A. Royer, Nadia R. Roan, Melanie Ott, Lishomwa C. Ndhlovu, Warner C. Greene   +12 more
doaj   +1 more source

Ethical considerations in HIV cure research [PDF]

Current Opinion in HIV and AIDS, 2013
Research directed toward an HIV cure presents ethical as well as scientific challenges.International guidelines, regulations, and the medical literature provide helpful guidance on protecting research participants.This review presents points to consider for researchers, sponsors, oversight committees, community advisory boards, and HIV advocates to ...
Bernard, Lo, Christine, Grady
openaire   +5 more sources

HIV Cure Research Crowdsourcing: An Author Response. [PDF]

AIDS Res Hum Retroviruses, 2018
Tucker JD, Zhang A, Zhao Y.
europepmc   +5 more sources

Potent latency reversal by Tat RNA-containing nanoparticle enables multi-omic analysis of the HIV-1 reservoir

Nature Communications, 2023
The development of latency reversing agents that potently reactivate HIV without inducing global T cell activation would benefit the field of HIV reservoir research and could pave the way to a functional cure.
Marion Pardons, Basiel Cole, Laurens Lambrechts, Willem van Snippenberg, Sofie Rutsaert, Ytse Noppe, Nele De Langhe, Annemieke Dhondt, Jerel Vega, Filmon Eyassu, Erik Nijs, Ellen Van Gulck, Daniel Boden, Linos Vandekerckhove   +13 more
doaj   +1 more source

Tools for Visualizing HIV in Cure Research [PDF]

Current HIV/AIDS Reports, 2018
The long-lived HIV reservoir remains a major obstacle for an HIV cure. Current techniques to analyze this reservoir are generally population-based. We highlight recent developments in methods visualizing HIV, which offer a different, complementary view, and provide indispensable information for cure strategy development.Recent advances in fluorescence ...
Julia, Niessl, Amy E, Baxter, Daniel E, Kaufmann   +2 more
openaire   +2 more sources

In-depth single-cell analysis of translation-competent HIV-1 reservoirs identifies cellular sources of plasma viremia

Nature Communications, 2021
To provide in depth characterization of HIV reservoir cells, the authors here develop a single-cell approach to simultaneously sequence TCR, integration sites and proviral genomes, called STIP-Seq, and show that the translation-competent reservoir mainly
Basiel Cole, Laurens Lambrechts, Pierre Gantner, Ytse Noppe, Noah Bonine, Wojciech Witkowski, Lennie Chen, Sarah Palmer, James I. Mullins, Nicolas Chomont, Marion Pardons, Linos Vandekerckhove   +11 more
doaj   +1 more source

HIV Cure Research: Risks Patients Expressed Willingness to Accept. [PDF]

Ethics Hum Res, 2019
ABSTRACTDespite doing well on antiretroviral therapy, many people living with HIV have expressed a willingness to accept substantial risks for an HIV cure. To date, few studies have assessed the specific quantitative maximal risk that future participants might take; probed whether, according to future participants, the risk can be offset by the ...
Kratka A, Ubel PA, Scherr K, Murray B, Eyal N, Kirby C, Katz MN, Holtzman L, Pollak K, Freedburg K, Blumenthal-Barby J.   +10 more
europepmc   +4 more sources