Leveraging early HIV diagnosis and treatment in Thailand to conduct HIV cure research. [PDF]
AIDS Res Ther, 2019 Thailand has the highest prevalence of HIV among countries in Asia but has also been a pioneer in HIV prevention and treatment efforts in the region, reducing the incidence of new infections significantly over the last two decades. Building upon this remarkable history, Thailand has set an ambitious goal to stop the AIDS epidemic in the country by 2030.
Muccini C +9 more
europepmc +6 more sources
Biomarker reveals HIV's hidden reservoir. [PDF]
, 2014 Determining the total amount of HIV DNA in people undergoing antiretroviral therapy could accelerate the development of novel therapies and potential cures for HIV ...
Cockerham, Leslie R, Deeks, Steven G
core +2 more sources
A Comparison of Miltefosine and Sodium Stibogluconate for Treatment of Visceral Leishmaniasis in an Ethiopian Population with High Prevalence of HIV Infection. [PDF]
, 2006 BACKGROUND: Antimonials are the mainstay of visceral leishmaniasis (VL) treatment in Africa. The increasing incidence of human immunodeficiency virus (HIV) coinfection requires alternative safe and effective drug regimens.
Abren Dejenie +14 more
core +2 more sources
Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals [PDF]
, 2020 Background: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regulation in cultured cells.
De Meyer, Tim +7 more
core +2 more sources
HIV Cure Research: Expanding the Ethical Considerations [PDF]
Annals of Internal Medicine, 2013 Mounting evidence is fueling excitement over the possibility of curing HIV infection. Research aimed at eliminating the need for continuous antiretroviral therapy includes a range of approaches, fr...
openaire +2 more sources
Towards Multidisciplinary HIV-Cure Research: Integrating Social Science with Biomedical Research [PDF]
Trends in Microbiology, 2016 The quest for a cure for HIV remains a timely and key challenge for the HIV research community. Despite significant scientific advances, current HIV therapy regimens do not completely eliminate the negative impact of HIV on the immune system; and the economic impact of treating all people infected with HIV globally, for the duration of their lifetimes,
Cynthia I, Grossman +8 more
openaire +2 more sources
Interventions for neurocognitive dysfunction [PDF]
, 2017 Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core +2 more sources
Integrating Community-Based Interventions to Reverse the Convergent TB/HIV Epidemics in Rural South Africa. [PDF]
, 2015 The WHO recommends integrating interventions to address the devastating TB/HIV co-epidemics in South Africa, yet integration has been poorly implemented and TB/HIV control efforts need strengthening.
Brooks, Ralph P +7 more
core +3 more sources
Journal of Virus Eradication, 2019 Objectives: To assess the safety and tolerability as well as antiretroviral impact of ABX464, an oral investigational drug with a novel mechanism of HIV-1 inhibition (ClinicalTrials.gov NCT02735863). Methods: Randomised, double-blind, placebo-controlled,
Sofie Rutsaert +9 more
doaj +1 more source
Roadblocks to translational challenges on viral pathogenesis. [PDF]
, 2013 Distinct roadblocks prevent translating basic findings in viral pathogenesis into therapies and implementing potential solutions in the clinic. An ongoing partnership between the Volkswagen Foundation and Nature Medicine resulted in an interactive ...
Deeks, Steven +4 more
core +1 more source