Results 51 to 60 of about 138,358 (278)

Organ-specific genome diversity of replication-competent SARS-CoV-2

Nature Communications, 2021
Here the authors provide a detailed virological analysis of thirteen postmortem COVID-19 cases, including presence of replication-competent SARS-CoV-2 in extrapulmonary organs and tissue-specific patterns of SARS-CoV-2 genome diversity of an ...
Jolien Van Cleemput, Willem van Snippenberg, Laurens Lambrechts, Amélie Dendooven, Valentino D’Onofrio, Liesbeth Couck, Wim Trypsteen, Jan Vanrusselt, Sebastiaan Theuns, Nick Vereecke, Thierry P. P. van den Bosch, Martin Lammens, Ann Driessen, Ruth Achten, Ken R. Bracke, Wim Van den Broeck, Jan Von der Thüsen, Hans Nauwynck, Jo Van Dorpe, Sarah Gerlo, Piet Maes, Janneke Cox, Linos Vandekerckhove   +22 more
doaj   +1 more source

Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1. [PDF]

, 2018
Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engraftment of gene-modified HSPCs in humanized mouse models.
An, Dong Sung, Arokium, Hubert, Chen, Irvin SY, Cortado, Ruth, Jung, Yujin, Kamata, Masakazu, Khamaikawin, Wannisa, Kim, Patrick, Kim, Sanggu, Lam, Jennifer, Presson, Angela P, Shimizu, Saki, Wen, Jing, Xie, Yiming   +13 more
core   +2 more sources

The California HIV/AIDS Research Program: History, Impact, and HIV Cure Initiative [PDF]

AIDS Research and Human Retroviruses, 2017
This Special Issue of AIDS Research and Human Retroviruses features results from the HIV Cure Initiative, funded by the California HIV/AIDS Research Program (CHRP). As a publicly funded grant maker, CHRP has served for more than three decades as a unique resource for innovative researchers in California, whose work seeks to address all aspects of the ...
Lisa Loeb, Stanga, Anwer, Mujeeb, Laura, Packel, Tyler, Martz, George, Lemp   +4 more
openaire   +2 more sources

HIV Reservoir Characterization Symposium

Journal of Virus Eradication, 2017
The HIV Cure Research Center (HCRC) in Ghent organised the first HIV Reservoir Characterization Symposium, and brought together virologists, molecular biologists, immunologists and clinicians to discuss the most recent developments in HIV reservoir ...
Eva Malatinkova, Ward De Spiegelaere, Linos Vandekerckhove, Magdalena Sips   +3 more
doaj   +1 more source

Re-examining the HIV ‘functional cure’ oxymoron: Time for precise terminology?

Journal of Virus Eradication, 2020
For over a decade, the binary concepts of ‘sterilizing’ versus ‘functional’ cure have provided an organizing framework for the field of HIV cure-related research.
Karine Dubé, Loreen Willenberg, Lynda Dee, Laurie Sylla, Jeff Taylor, Christopher Roebuck, David Palm, Danielle Campbell, Luke Newton, Hursch Patel, Kelly E. Perry, John Kanazawa, Jo Gerrard, Brandon Brown, Parya Saberi, John A. Sauceda, Michael J. Peluso   +16 more
doaj   +1 more source

Access to HIV prevention and care for HIV-exposed and HIV-infected children : a qualitative study in rural and urban Mozambique [PDF]

, 2014
Background: Follow-up of HIV-exposed children for the delivery of prevention of mother-to-child transmission services and for early diagnosis and treatment of HIV infection is critical to their survival.
Bobrow, Emily A, De Schacht, Caroline, Dimande, Stelio A, Gill, Michelle, Guay, Laura, Lucas, Carlota, Macasse, Eugenia, Mboa, Catarina   +7 more
core   +2 more sources

Research on HIV cure: Mapping the ethics landscape

PLOS Medicine, 2017
According to current estimates, 36.7 million people are infected with HIV worldwide. Despite large-scale and growing programs to prevent and treat HIV infection, possible approaches to achieve a cure for HIV infection are of strong interest. In the development of candidate approaches to achieve an HIV cure, issues of future translation to human study ...
Karine Dubé, Laurie Sylla, Lynda Dee, Jeff Taylor, David Evans, Carl Dean Bruton, Adam Gilberston, Lisa Gralinski, Brandon Brown, Asheley Skinner, Bryan J. Weiner, Sandra B. Greene, Amy Corneli, Adaora A. Adimora, Joseph D. Tucker, Stuart Rennie   +15 more
openaire   +4 more sources

Integrating tuberculosis and HIV care in the primary care setting in South Africa. [PDF]

, 2004
BACKGROUND: In many countries including South Africa, the increasing human immunodeficiency virus (HIV) and tuberculosis (TB) epidemics have impacted significantly on already weakened public health services.
Anderson SR, Cantwell MF, Godfrey-Faussett P, Maher D, Rieder HL, World Health Organization   +5 more
core   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Regulatory T Cells As Potential Targets for HIV Cure Research. [PDF]

Front Immunol, 2018
T regulatory cells (Tregs) are a key component of the immune system, which maintain a delicate balance between overactive responses and immunosuppression. As such, Treg deficiencies are linked to autoimmune disorders and alter the immune control of pathogens. In HIV infection, Tregs play major roles, both beneficial and detrimental.
Kleinman AJ, Sivanandham R, Pandrea I, Chougnet CA, Apetrei C.   +4 more
europepmc   +5 more sources