Results 71 to 80 of about 138,358 (278)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Blood and tissue HIV-1 reservoirs display plasticity and lack of compartmentalization in virally suppressed people

Nature Communications
Characterizing the HIV-1 reservoir in blood and tissues is crucial for the development of curative strategies. Using an HIV Tat mRNA-containing lipid nanoparticle (Tat-LNP) in combination with panobinostat, we show that p24+ cells from blood and lymph ...
Marion Pardons, Laurens Lambrechts, Ytse Noppe, Liesbet Termote, Sofie De Braekeleer, Jerel Vega, Ellen Van Gulck, Sarah Gerlo, Linos Vandekerckhove   +8 more
doaj   +1 more source

"I would really want to know that they had my back": Transgender women's perceptions of HIV cure-related research in the United States.

PLoS ONE, 2020
Forty-four percent of Black transgender women are living with HIV, and many face challenges with HIV care engagement. An HIV cure has much to offer this population, however little HIV cure-related research has included them.
Tonia Poteat, Anushka Aqil, Dana Corbett, David Evans, Karine Dubé   +4 more
doaj   +1 more source

Indirect Benefits in HIV Cure Clinical Research: A Qualitative Analysis [PDF]

AIDS Research and Human Retroviruses, 2019
Currently, much of early phase HIV cure research involves unknown and potentially serious risks, with little or no chance of direct health benefits. During informed consent, researchers emphasize this lack of personal medical benefit to minimize misconceptions that undermine genuine consent.
Gilbertson, Adam, Kelly, Elizabeth Poole, Rennie, Stuart, Henderson, Gail, Kuruc, JoAnn, Tucker, Joseph D   +5 more
openaire   +3 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Community participation in HIV cure research: perspectives from Thailand

Journal of Virus Eradication, 2015
Thailand aims to end its AIDS epidemic by 2030, and key strategies to effect this include an increase in HIV testing coverage to 90% for key populations (i.e. men who have sex with men, sex workers, people who inject drugs and partners of people living with HIV) and antiretroviral treatment (ART) initiation for all, regardless of CD4 cell count.
Nittaya Phanuphak, Praphan Phanuphak, Nimitr Tien-Udom   +2 more
openaire   +3 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

'Well, It's the Risk of the Unknown… Right?': A Qualitative Study of Perceived Risks and Benefits of HIV Cure Research in the United States.

PLoS ONE, 2017
IntroductionBiomedical research towards an HIV cure is advancing in the United States and elsewhere, yet little is known about perceptions of risks and benefits among potential study participants and other stakeholders.
Karine Dubé, Jeff Taylor, Laurie Sylla, David Evans, Lynda Dee, Alasdair Burton, Loreen Willenberg, Stuart Rennie, Asheley Skinner, Joseph D Tucker, Bryan J Weiner, Sandra B Greene   +11 more
doaj   +1 more source

Launching a multidisciplinary European collaboration towards a cure for HIV: The EU2Cure Consortium

Journal of Virus Eradication, 2021
We felt the urgency to launch the EU2Cure Consortium to support research and find a cure for the human immunodeficiency virus (HIV) infection through intensified collaboration within Europe.
C. Rokx, H.A.B. Prins, L. Vandekerckhove, S.J. Fidler, J. Frater, M. Bracchi, O.S. Søgaard, M. Tolstrop, T.A. Rasmussen, M. Salgado, J. Blanco, J. Martinez-Picado, B. Clotet, G. Tambussi, A. Groenendijk, A. Verbon, C.A.B. Boucher   +16 more
doaj   +1 more source

Impact of antiretroviral therapy on adult HIV prevalence in a low-income rural setting in Uganda: a longitudinal population-based study.

, 2013
OBJECTIVE: To estimate the contribution to HIV prevalence of lives saved due to the introduction of antiretroviral therapy (ART) in rural Uganda in 2004. DESIGN: Open population-based cohort study.
Maher, Dermot, Nsubuga, Rebecca N, Todd, Jim E   +2 more
core   +1 more source