Results 91 to 100 of about 138,358 (278)
Arthritis Care &Research, EarlyView.Objective Despite well‐described biologic causes, the public views unhealthy lifestyle choices as the primary cause of gout. This study investigated how causal beliefs about gout influence the public's views about its management. Methods In a randomized study, 201 members of the public viewed one of two 2‐minute videos about gout.
Rachel Murdoch +6 more
wiley +1 more source
A new paradigm evaluating cost per cure of HCV infection in the UK [PDF]
, 2016 Background: New interferon (IFN)-free treatments for hepatitis C are more effective, safer but more expensive than current IFN-based therapies. Comparative data of these, versus current first generation protease inhibitors (PI) with regard to costs and ...
Aline Gauthier +7 more
core +2 more sources
Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers
Advanced Functional Materials, EarlyView.A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley +1 more source
Nanodiamond Quantum Sensors for Probing Free Radical Biology
Advanced Functional Materials, EarlyView.Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley +1 more source
PP 1.23 – 00130 Long-read sequencing assay allows accurate characterization of the HIV-1 reservoir
Journal of Virus Eradication, 2022 L. Lambrechts +7 more
doaj +1 more source
Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes
Advanced Healthcare Materials, EarlyView.A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu +6 more
wiley +1 more source
Interrupting antiretroviral treatment in HIV cure research: scientific and ethical considerations. [PDF]
J Virus Erad, 2017 Over the past several years there has been intense activity directed at the possibility of achieving remission or eradication of HIV infection. Current assays for the measurement of latent HIV are insufficient to demonstrate complete clearance of replication-competent HIV. Therefore, the ultimate test for assessing whether investigational interventions
Garner SA +8 more
europepmc +4 more sources
Stem-cell-based gene therapy for HIV infection. [PDF]
, 2013 Despite the enormous success of combined anti-retroviral therapy, HIV infection is still a lifelong disease and continues to spread rapidly worldwide. There is a pressing need to develop a treatment that will cure HIV infection.
Kitchen, Scott, Zhen, Anjie
core +2 more sources
Asian Pacific Journal of Tropical Disease, 2015 There are over 100 clinical trials worldwide focused on developing an HIV cure. Research participants will assume substantial individual risks while receiving little or no individual benefit. Physicians will have important dual roles of leading HIV cure research studies and guiding patient expectations.
Zachary Clarke, Rich +6 more
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.This review summarizes the roles of key central nervous system cell types, the extracellular matrix, and the blood‐brain barrier in neuroinflammation, and their integration into diverse 3D culture systems. It examines major incorporation strategies, including direct co‐culture, hydrogel encapsulation, transwell migration assays, and bioprinting ...
Emmanuelle D. Aiyegbusi +2 more
wiley +1 more source