Results 111 to 120 of about 138,358 (278)

Interactome of the HIV-1 proteome and human host RNA

EMBO Reports
The human immunodeficiency virus (HIV-1) is highly dependent on a variety of host factors. Beside proteins, host RNA molecules are reported to aid HIV-1 replication and latency maintenance.
Tinus Schynkel, Willem van Snippenberg, Kimberly Verniers, Gwendolyn M Jang, Nevan J Krogan, Pieter Mestdagh, Linos Vandekerckhove, Wim Trypsteen   +7 more
doaj   +1 more source

Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial [PDF]

, 2017
Background : By the early 1980s, tuberculosis treatment was shortened from 24 to 6 months, maintaining relapse rates of 1-2%. Subsequent trials attempting shorter durations have failed, with 4-month arms consistently having relapse rates of 15-20%.
Alland, D, Arora, K, Barry Iii, CE, Cai, Y, Chen, RY, Dawson, R, Diacon, AH, Dodd, LE, Duan, H, Duvenhage, M, Gao, Q, Goldfeder, LC, Hatherill, M, Jiang, Q, Jin, X, Liang, L, Liu, X, Loxton, AG, Ma, Z, Malherbe, ST, Pan, S, Predict TB Study Group, Rosenthal, A, Smith, B, Song, T, Tameris, M, Tartakovsky, M, Thienemann, F, Via, LE, Walzl, G, Whalen, C, Wilkinson, RJ, Winter, J, Xing, J, Zhang, G, Zhu, H   +35 more
core   +2 more sources

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Development and Evaluation of a Novel Relatively Low-Cost Method to Derive HIV-1 Integration Sites and Proviral Sequences

Viruses
In people taking antiretroviral therapy (ART) for HIV infection, the methods to characterize latent and active HIV reservoirs remain costly and labor-intensive.
Samantha R. Hardy, Sheila Styrchak, Tim De Meyer, Laurens Lambrechts, Tine Struyve, Basiel Cole, Liesbet Termote, Sherry McLaughlin, James I. Mullins, Linos Vandekerckhove, Lisa M. Frenkel   +10 more
doaj   +1 more source

Gene Therapy Targeting HIV Entry

Viruses, 2014
Despite the unquestionable success of antiretroviral therapy (ART) in the treatment of HIV infection, the cost, need for daily adherence, and HIV-associated morbidities that persist despite ART all underscore the need to develop a cure for HIV.
Chuka Didigu, Robert Doms
doaj   +1 more source

Can a pill prevent HIV? Negotiating the biomedicalisation of HIV prevention [PDF]

, 2015
This article examines how biomedicalisation is encountered, responded to and negotiated within and in relation to new biomedical forms of HIV prevention.
Flowers, Paul, McDaid, Lisa, Young, Ingrid   +2 more
core   +2 more sources

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

‘I can coexist with HIV’: a qualitative study of perceptions of HIV cure among people living with HIV in Guangzhou, China

Journal of Virus Eradication, 2016
Little is known about perceptions of HIV cure among people living with HIV (PLHIV), despite them being crucial stakeholders in ongoing HIV cure research.
Qingyan Ma, Feng Wu, Gail Henderson, Stuart Rennie, Zachary C. Rich, Yu Cheng, Fengyu Hu, Weiping Cai, Joseph D. Tucker   +8 more
doaj   +1 more source

A Keratinocyte‐Mast Cell NF‐κB2/CXCL2/IL‐6 Amplification Loop Enhances Cutaneous Antifungal Defense Against C. albicans

Advanced Science, EarlyView.
ABSTRACT Mast cells (MCs), key innate immune sentinels at the host–environment interface, serve as primary responders to invading pathogens. However, their specific contribution to host defense against cutaneous Candida albicans (C. albicans) infection and their synergy with other immune and non‐immune cells remain poorly understood. Here, we show that
Yan Yuan, Manyun Mao, Jiaan Zhang, Zhimin Duan, JiaNing Wang, Yujie Chen, Sihan Chen, Chuting Liang, Xvyue Zhou, Songmei Geng, Min Li, Xu Chen, Ni Lian   +12 more
wiley   +1 more source

Reduced healthcare utilisation following successful HCV treatment in HIV co-infected patients with mild liver disease [PDF]

, 2015
New direct-acting antivirals (DAA) for hepatitis C virus (HCV) infection have achieved high cure rates in many patient groups previously considered difficult-to-treat, including those HIV/HCV co-infected.
Clark, S, Cooke, GS, Gellisen, R, Irving, W, Main, J, Padam, P, Thomson, E   +6 more
core   +2 more sources