Results 131 to 140 of about 138,358 (278)

Achieving the global agenda toward HIV cure calls for establishing a research-for-cure academy in West and Central Africa

Journal of Virus Eradication
Despite global efforts to eliminate HIV as a public health threat, sub-Saharan Africa (SSA) still harbours about the highest burden of the pandemic, home to around 70 % of people living with HIV with limited contribution in the field of HIV cure research,
Aude Christelle Ka'e, Collins Ambe Chenwi, Livo Esemu, Hillary Tene, Romeo Djounda, Bouba Yagai, Aubin Nanfack, Alex Durand Nka, Naomi-Karell Etame, Ezechiel Ngoufack Jagni Semengue, Celestin Godwe, Honore Awanakan, Fon Abongwa Acho, Caroline Mofor, Mambo Musi Beryle, Benoit Bissohong, Jang Joanes T, Lum Forgwei, Rogers Ajeh Awoh, Gregory Edie Halle Ekane, R Brad Jones, Marcel Tongo, Almoustapha-Issiaka Maiga, Thomas Toni, Adawaye Chatte, Christian Mangala, Denis Maulot Bangola, Abou Abdallah Malik Diouara, Djibril Wade, Elvis Temfack, Sofonias Kifle Tessema, Erick Ntambwe Kamangu, Christian Diamant Mossoro-Kpinde, Mobereade Ayokamnmi, Laure Stella Ghoma Linguissi, Charles Kouanfack, Alexis Ndjolo, Souleymane Tassembedo, Vittorio Colizzi, Diana Boraschi, Krista L. Dong, Karine Dubé, Nicaise Ndembi, Steven G. Deeks, Caroline T. Tiemessen, Thumbi Ndung'u, Carlo-Federico Perno, Deborah Persaud, Joseph Fokam   +48 more
doaj   +1 more source

Gold Ash: Contested yet Immortal, The Exceptional Potency of Burmese Alchemy [PDF]

, 2019
‘Gold ash’ (shway pya), a substance Burmese alchemists produce through a complex process of the combination and burning of metals, is considered by many Burmese as the most potent medical ingredient existing in the country. In this article, I explore the
Coderey, Céline
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Development of a Human 3D Immune‐Competent Neurovascular Model Enabling Time‐Resolved Monitoring of Neuroinflammatory Dynamics and Neuroimmune Interactions

Advanced Science, EarlyView.
Neuroinflammation alters blood–brain barrier integrity and contributes to neurological disorders, yet existing models lack human immune complexity. This study presents a 3D, immune‐responsive platform that reconstructs key neurovascular components and enables real‐time monitoring.
Pavlo Gordiichuk, Jing Bai, Olurotimi A. Bolonduro, Andrew M. Silverman, Robert Madison Green, Jason H. Lasser, Paul W. Fleming, Lishomwa C. Ndhlovu, James F. Saunders, Dmitry Shvartsman   +9 more
wiley   +1 more source

ZDHHC18‐Mediated Palmitoylation of ORF3a Promotes SARS‐CoV‐2 Pathogenesis by Antagonizing TRIM16‐Mediated Ubiquitination and Proteasomal Degradation

Advanced Science, EarlyView.
Palmitoylation by ZDHHC18 blocks ORF3a K27‐linked ubiquitination mediated by TRIM16, thereby preventing its proteasomal degradation and strengthening viral pathogenesis. Targeting palmitoylation through a pharmacological inhibitor (2‐BP), a competitive inhibitory peptide (OPIP), or adenovirus‐mediated knockdown of ZDHHC18 expression presents a ...
Sidi Yang, Kun Li, Lihong Liu, Linsen Zeng, Qifeng Deng, Jiacheng Huang, Xiaoran Dong, Xin Wang, Jianwei Liang, Hongchao Liu, Hong Peng, Yuxin Lin, Xiaolu Xie, Yuzhen Ye, Tiefeng Xu, Zhaohuan Wang, Chun‐Mei Li, Deyin Guo   +17 more
wiley   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Prevention is a solution: building the HIVe [PDF]

, 2012
This Special Issue of Digital Culture and Education (DCE), Building the HIVe, offers relevant and applicable examples of digital technologies being leveraged, positioned and practiced towards community-based and led HIV prevention as a solution in a ...
Singh, Gurmit, Walsh, Christopher
core  

Growing up with HIV: The experiences of young people living with HIV since birth in the UK [PDF]

, 2008
About the book: This book draws together a range of both classic and newly commissioned pieces on the multidisciplinary study of death and dying. Organized into five parts, the book begins with a general exploration of the meaning of death, before ...
Dorrell, Judith, Earle, Sarah, Katz, Jeanne, Reveley, Shirley   +3 more
core  

Machine Learning‐Enhanced Random Matrix Theory Design for Human Immunodeficiency Virus Vaccine Development

Advanced Intelligent Discovery, EarlyView.
This study integrates random matrix theory (RMT) and principal component analysis (PCA) to improve the identification of correlated regions in HIV protein sequences for vaccine design. PCA validation enhances the reliability of RMT‐derived correlations, particularly in small‐sample, high‐dimensional datasets, enabling more accurate detection of ...
Mariyam Siddiqah, Muhammad Zulqarnain Zeb, Muhammad Husnain Zeb, Babar Shabbir   +3 more
wiley   +1 more source