Results 131 to 140 of about 170,053 (305)

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

Immunology, EarlyView.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto, Alfredo Santovito, Gian P. Caviglia, Marta Noli, Davide Cossu, Davide G. Ribaldone, Demis Pitoni, Simona Frara, Elisa Tribocco, Chiara Rosso, Marta Guriglia, Ilaria Cossu, Pier A. Tovo, Massimiliano Bergallo, Leonardo A. Sechi   +14 more
wiley   +1 more source

Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.

PLoS Genetics, 2020
In mitosis and meiosis, chromosome segregation is triggered by the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit ubiquitin ligase that targets proteins for degradation, leading to the separation of chromatids.
Damien Garrido, Mohammed Bourouh, Éric Bonneil, Pierre Thibault, Andrew Swan, Vincent Archambault   +5 more
doaj   +1 more source

Meiotic irregularities in Alstroemeria andina var. Venustula (Alstroemeriaceae) [PDF]

, 2007
Alstroemeria andina Phil. var. venustula (Phil.) M. Muñoz (sub nom. A. andina Phil. subsp. venustula (Phil.) Ehr. Bayer) is a perennial, small herb, 5-16 cm tall, that occurs mainly at 2,800-3,700 meters above sea level, in populations of limited ...
Sanso, Andrea Mariel, Wulff, Arturo Federico   +1 more
core  

Induction of Synthetic Apomixis in Two Sorghum Hybrids Enables Seed Yield and Genotype Preservation Over Multiple Generations

Plant Biotechnology Journal, EarlyView.
ABSTRACT Induction of apomixis, or clonal reproduction through seed, could economise commercial hybrid seed production and enable smallholder farmers to save and sow hybrid seed. Here, we demonstrate the synthetic induction of apomixis in two sorghum hybrids and show that the clonal hybrid seed can be maintained across multiple seed generations.
Marissa K. Simon, Li Yuan, Ping Che, Kevin Day, Todd Jones, Ian D. Godwin, Anna M. G. Koltunow, Marc C. Albertsen   +7 more
wiley   +1 more source

Poleward Microtubule Flux Is a Major Component of Spindle Dynamics and Anaphase A in Mitotic Drosophila Embryos [PDF]

, 2002
Paul S. Maddox, Arshad Desai, Karen Oegema, Timothy J. Mitchison, Edward D. Salmon   +4 more
openalex   +1 more source

The mechanism of anaphase spindle elongation: uncoupling of tubulin incorporation and microtubule sliding during in vitro spindle reactivation. [PDF]

, 1988
To study tubulin polymerization and microtubule sliding during spindle elongation in vitro, we developed a method of uncoupling the two processes. When isolated diatom spindles were incubated with biotinylated tubulin (biot-tb) without ATP, biot-tb was ...
CANDE, W. Zacheus, Masuda, H, McDonald, K   +2 more
core  

Whose end is destruction: cell division and the anaphase-promoting complex.

Genes & Development, 1999
Cell proliferation depends on the duplication of chromosomes followed by the segregation of duplicates (sister chromatids) to opposite poles of the cell prior to cell division (cytokinesis).
W. Zachariae, K. Nasmyth
semanticscholar   +1 more source

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Supplemental File 2 from CDK2 Inhibition Causes Anaphase Catastrophe in Lung Cancer through the Centrosomal Protein CP110

, 2023
Shanhu Hu, Alexey V. Danilov, Kristina Godek, Bernardo Orr, Laura J. Tafe, Jaime Rodriguez‐Canales, Carmen Behrens, Barbara Mino, César A. Moran, Vincent A. Memoli, Lisa Maria Mustachio, Fabrizio Galimberti, Saranya Ravi, Andrew DeCastro, Yun Lu, David Sekula, Angeline S. Andrew, Ignacio I. Wistuba, Sarah J. Freemantle, Duane A. Compton, Ethan Dmitrovsky   +20 more
openalex   +1 more source

The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation.

Genes & Development, 1998
The spindle assembly checkpoint mechanism delays anaphase initiation until all chromosomes are aligned at the metaphase plate. Activation of the anaphase-promoting complex (APC) by binding of CDC20 and CDH1 is required for exit from mitosis, and APC has ...
G. Fang, Hongtao Yu, Hongtao Yu, M. Kirschner   +3 more
semanticscholar   +1 more source