Results 141 to 150 of about 167,277 (315)

Patronin mediates a switch from kinesin-13–dependent poleward flux to anaphase B spindle elongation

Journal of Cell Biology, 2013
Patronin counteracts KLP10A activity at spindle poles to stabilize microtubule minus ends and induce spindle elongation during anaphase B.
Haifeng Wang, I. Brust-Mascher, G. Civelekoglu-Scholey, J. Scholey   +3 more
semanticscholar   +1 more source

Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are considered a privileged scaffold in medicinal chemistry, as they may interact with biological macromolecules, presenting several pharmacological properties. Their potential makes them an object of study for the evaluation of their safety for humans, which is essential in the design of a potential drug.
Júlia Zocca Nunes de Barros, Luma Eduarda Lopes Escalante, Maria João Matos, Edson Luis Maistro   +3 more
wiley   +1 more source

Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.

PLoS Genetics, 2020
In mitosis and meiosis, chromosome segregation is triggered by the Anaphase-Promoting Complex/Cyclosome (APC/C), a multi-subunit ubiquitin ligase that targets proteins for degradation, leading to the separation of chromatids.
Damien Garrido, Mohammed Bourouh, Éric Bonneil, Pierre Thibault, Andrew Swan, Vincent Archambault   +5 more
doaj   +1 more source

Meiotic irregularities in Alstroemeria andina var. Venustula (Alstroemeriaceae) [PDF]

, 2007
Alstroemeria andina Phil. var. venustula (Phil.) M. Muñoz (sub nom. A. andina Phil. subsp. venustula (Phil.) Ehr. Bayer) is a perennial, small herb, 5-16 cm tall, that occurs mainly at 2,800-3,700 meters above sea level, in populations of limited ...
Sanso, Andrea Mariel, Wulff, Arturo Federico   +1 more
core  

PI 3-kinase-dependent phosphorylation of Plk1–Ser99 promotes association with 14-3-3γ and is required for metaphase–anaphase transition

Nature Communications, 2013
Polo-like kinase 1 (Plk1) controls multiple aspects of mitosis and is activated through its phosphorylation at Thr210. Here we identify Ser99 on Plk1 as a novel mitosis-specific phosphorylation site, which operates independently of Plk1–Thr210 ...
Kousuke Kasahara, H. Goto, I. Izawa, T. Kiyono, N. Watanabe, S. Elowe, E. Nigg, M. Inagaki   +7 more
semanticscholar   +1 more source

Acute Toxicity and Genotoxicity of cMoL, a Lectin From Moringa oleifera Seeds With Antifungal Activity Against Cryptococcus Strains

Journal of Applied Toxicology, EarlyView.
ABSTRACT Coagulant Moringa oleifera lectin (cMoL) is one of the compounds involved in the application of M. oleifera seeds for traditional water treatment methods. The present study highlights the new biotechnological potential of cMoL lectin as an antifungal agent against Cryptococcus neoformans B3501 and H99 and Cryptococcus gattii R265 strains ...
Matheus Cavalcanti de Barros, Sávia Soraia Santana da Silva, Eduarda Pinto Gagliano, Alícia Natalie Silva dos Santos, Leydianne Leite de Siqueira Patriota, Gustavo Ramos Salles Ferreira, Pollyanna Michelle da Silva, Simone da Paz Leôncio Alves, Julliano Matheus de Lima Maux, Jacinto da Costa Silva Neto, Fernanda Rafaelly Nascimento de Santana, Fabiana Aparecida Cavalcante Silva, Marilene Henning Vainstein, Luana Cassandra Breitenbach Barroso Coelho, Thâmarah de Albuquerque Lima, Thiago Henrique Napoleão, Patrícia Maria Guedes Paiva   +16 more
wiley   +1 more source

The mechanism of anaphase spindle elongation: uncoupling of tubulin incorporation and microtubule sliding during in vitro spindle reactivation. [PDF]

, 1988
To study tubulin polymerization and microtubule sliding during spindle elongation in vitro, we developed a method of uncoupling the two processes. When isolated diatom spindles were incubated with biotinylated tubulin (biot-tb) without ATP, biot-tb was ...
CANDE, W. Zacheus, Masuda, H, McDonald, K   +2 more
core  

Calpain Proteases and the Evolving Signaling Network in Insect Embryonic Patterning

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Insect embryonic Dorsal‐Ventral (DV) patterning relies on the BMP and Toll pathways to different extents. Calcium‐dependent cystein proteases of the Calpain family also exert an important function to pattern the DV axis. In Drosophila, Calpain A cleaves the Cactus/IkappaB inhibitor and modifies Toll signals in ventral regions of the embryo. In Rhodnius
Alison Julio, Helena Araujo
wiley   +1 more source

Ecotoxicological Evaluation of the Antimicrobial Butylparaben in Edaphic Organisms Using Multiple Biomarkers

Environmental Toxicology, EarlyView.
ABSTRACT Butylparaben (BuP) recurrently contaminates soils worldwide, mainly by incorporating sewage sludge into cultivated areas, using wastewater in irrigation, and leaching contaminated soils. However, there are few studies on the ecotoxicological effects of this paraben on edaphic organisms.
Lorena Maihury Santos Tsubouchi, Edson Araújo de Almeida, Diane Scapin, Anna Karolina Gomes Oliveira, Cassiano Aparecido de Souza, Diego Espirito Santo, Carmem Lúcia Henrich, Ana Elisa Maehashi, Gideã Taques Tractz, Craig Allan Downs, Osvaldo Valarini Junior, Regiane da Silva Gonzalez, Elisângela Düsman, Ana Paula Peron   +13 more
wiley   +1 more source

THE BEHAVIOR OF STRONG AND WEAK CENTROMERES AT SECOND ANAPHASE OF DROSOPHILA MELANOGASTER [PDF]

, 1960
Mark Ptashne
openalex   +1 more source