Results 241 to 250 of about 52,438 (267)

The Plant Anaphase-Promoting Complex/Cyclosome

Annual Review of Cell and Developmental Biology, 2022
The anaphase-promoting complex/cyclosome (APC/C) represents a large multisubunit E3-ubiquitin ligase complex that controls the unidirectional progression through the cell cycle by the ubiquitination of specific target proteins, marking them for proteasomal destruction.
Willems, Alex, De Veylder, Lieven
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Nocodazole pretreatment in anaphase selectively reduces anaphase B in PtK1 cells

Cell Motility, 1983
AbstractDuring early anaphase PtK1 cells were briefly treated with the rapidly reversible microtubule (MT) poison nocodazole. This treatment abruptly stopped chromosome motion and effected a large decrease in spindle birefringence. On removal of the drug, chromosome to pole motion (anaphase A) returned, though at a lesser rate but not extent than ...
Sandra I. Vogt, Sandra L. Mclelland, Judith A. Snyder   +2 more
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The mechanism of anaphase spindle elongation

BioEssays, 1989
AbstractAt anaphase chromosomes move to the spindle poles (anaphase A) and the spindle poles move apart (anaphase B). In vitro studies using isolated diatom spindles demonstrate that the primary mechano‐chemical event responsible for spindle elongation is the sliding apart of half‐spindle microtubules.
W. Z. Cande, C. J. Hogan
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Chromosome errors at mitotic anaphase

Genome, 1992
Errors in mitotic divisions were assayed using various satellite DNAs as probes, hybridized in situ, to show that they included nondisjunction, chromosome and chromatid lagging, chromatid malsegregation, and monopolar segregations. The total rates of error were 1.7, 1.1, and 0.6% for chromosomes X, 17, and 18, respectively. Lagging was the most common
Anthony Correll, Judith H. Ford
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Anaphase Inactivation of the Spindle Checkpoint

Science, 2006
The spindle checkpoint delays cell cycle progression until microtubules attach each pair of sister chromosomes to opposite poles of the mitotic spindle. Following sister chromatid separation, however, the checkpoint ignores chromosomes whose kinetochores are attached to only one spindle pole, a state that activates the checkpoint prior to metaphase. We
Janet B. Meehl, Sue L. Jaspersen, William J. Palframan, Andrew W. Murray, Mark Winey   +4 more
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Nucleotide requirements for anaphase chromosome movements in permeabilized mitotic cells: Anaphase B but not anaphase a requires ATP

Cell, 1982
Permeabilized PtK1 cells continue to undergo anaphase chromosome movements provided MgATP is included in the lysis medium. However, chromosome-to-pole movement (anaphase A) and spindle elongation (anaphase B) differ with respect to nucleotide requirements.
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Rephrasing anaphase: separase FEARs shugoshin

Chromosoma, 2005
Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has recently been extended by exciting discoveries on three levels: regulation of anaphase by posttranslational modifications and the cohesin protector shugoshin; non-proteolytic roles of separase; and cohesin-independent ...
Stemmann, Olaf, Boos, Dominik, Gorr, Ingo H.   +2 more
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Lactate regulates cell cycle by remodelling the anaphase promoting complex

Nature, 2023
Weihai Liu, Yun Wang, L. Bozi, P. Fischer, Mark P. Jedrychowski, Haopeng Xiao, Tao Wu, Narek Darabedian, Xiadi He, E. Mills, Nils Burger, Sanghee Shin, Anita Reddy, Hans-Georg Sprenger, Nhien V. Tran, Sally Winther, S. Hinshaw, Jingnan Shen, H. Seo, Kijun Song, A. Xu, Luke Sebastian, Jean Zhao, S. Dhe-Paganon, Jianwei Che, S. Gygi, H. Arthanari, Edward T. Chouchani   +27 more
semanticscholar   +1 more source

Enzymology of the Anaphase‐Promoting Complex

2005
The anaphase-promoting complex (APC) is an ubiquitin-protein ligase that promotes mitotic progression by catalyzing the ubiquitination of numerous proteins, including securin and cyclin. Its complex subunit composition and extensive regulation make the APC an active subject of investigation for both cell biologists and enzymologists.
David O. Morgan, Christopher W. Carroll
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Cohesin and Cdk1: an anaphase barricade

Nature Cell Biology, 2010
Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
openaire   +3 more sources