Results 291 to 300 of about 78,527 (313)

Chromosome errors at mitotic anaphase

Genome, 1992
Errors in mitotic divisions were assayed using various satellite DNAs as probes, hybridized in situ, to show that they included nondisjunction, chromosome and chromatid lagging, chromatid malsegregation, and monopolar segregations. The total rates of error were 1.7, 1.1, and 0.6% for chromosomes X, 17, and 18, respectively. Lagging was the most common
Anthony Correll, Judith H. Ford
openaire   +3 more sources

Anaphase Inactivation of the Spindle Checkpoint

Science, 2006
The spindle checkpoint delays cell cycle progression until microtubules attach each pair of sister chromosomes to opposite poles of the mitotic spindle. Following sister chromatid separation, however, the checkpoint ignores chromosomes whose kinetochores are attached to only one spindle pole, a state that activates the checkpoint prior to metaphase. We
Janet B. Meehl, Sue L. Jaspersen, William J. Palframan, Andrew W. Murray, Mark Winey   +4 more
openaire   +3 more sources

Nucleotide requirements for anaphase chromosome movements in permeabilized mitotic cells: Anaphase B but not anaphase a requires ATP

Cell, 1982
Permeabilized PtK1 cells continue to undergo anaphase chromosome movements provided MgATP is included in the lysis medium. However, chromosome-to-pole movement (anaphase A) and spindle elongation (anaphase B) differ with respect to nucleotide requirements.
openaire   +3 more sources

Rephrasing anaphase: separase FEARs shugoshin

Chromosoma, 2005
Cleavage of the ring-like cohesin complex by separase triggers segregation of sister chromatids in anaphase. This simplistic model has recently been extended by exciting discoveries on three levels: regulation of anaphase by posttranslational modifications and the cohesin protector shugoshin; non-proteolytic roles of separase; and cohesin-independent ...
Stemmann, Olaf, Boos, Dominik, Gorr, Ingo H.   +2 more
openaire   +3 more sources

Lactate regulates cell cycle by remodelling the anaphase promoting complex

Nature, 2023
Weihai Liu, Yun Wang, L. Bozi, P. Fischer, Mark P. Jedrychowski, Haopeng Xiao, Tao Wu, Narek Darabedian, Xiadi He, E. Mills, Nils Burger, Sanghee Shin, Anita Reddy, Hans-Georg Sprenger, Nhien V. Tran, Sally Winther, S. Hinshaw, Jingnan Shen, H. Seo, Kijun Song, A. Xu, Luke Sebastian, Jean Zhao, S. Dhe-Paganon, Jianwei Che, S. Gygi, H. Arthanari, Edward T. Chouchani   +27 more
semanticscholar   +1 more source

Enzymology of the Anaphase‐Promoting Complex

2005
The anaphase-promoting complex (APC) is an ubiquitin-protein ligase that promotes mitotic progression by catalyzing the ubiquitination of numerous proteins, including securin and cyclin. Its complex subunit composition and extensive regulation make the APC an active subject of investigation for both cell biologists and enzymologists.
David O. Morgan, Christopher W. Carroll
openaire   +3 more sources

Cohesin and Cdk1: an anaphase barricade

Nature Cell Biology, 2010
Separation of sister chromatids at anaphase in metazoan cells requires only the cleavage of the kleisin subunit of centromeric cohesin, but efficient poleward movement of separated sisters requires the associated loss in Cdk1 activity. Activation of the anaphase-promoting complex/cyclosome ensures these events are coordinated.
openaire   +3 more sources

?Premature anaphase? in a couple with recurrent miscarriages

Human Genetics, 1993
An increased frequency of mitoses with centromere separation affecting all chromosomes was found in lymphocyte cultures from a couple with recurrent spontaneous abortions. The phenomenon was observed in both the wife and husband. The abnormal behaviour of centromeres may predispose the individual to cell division errors, the consequence of which may be
Katalin Bajnóczky, S. Gardó
openaire   +2 more sources

The anaphase promoting complex/cyclosome: a machine designed to destroy

Nature reviews. Molecular cell biology, 2006
J. Peters
semanticscholar   +1 more source

The Events and Regulation of Anaphase Onset

1993
Aneuploidy results from the mal-segregation of one or more chromosomes during mitosis or meiosis. It can occur from the non-disjunction of a chromosome, the complete failure of a chromosome to attach to the spindle, the assembly of a multipolar spindle, or the failure of a monooriented chromosome to achieve a bipolar attachment prior to chromatid ...
Greenfield Sluder, Conly L. Rieder
openaire   +2 more sources