Results 91 to 100 of about 138,544 (375)

Long‐Term Safety and Efficacy of Mepolizumab in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Objective Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare, relapsing, inflammatory disease. Management of EGPA predominantly relies on oral corticosteroids (OCS), which are associated with many adverse effects. The phase 3 MIRRA trial demonstrated efficacy and safety of mepolizumab, anti‐interleukin‐5 biologic, for EGPA.
Michael E. Wechsler, Jared Silver, Gerhard Wolff, Robert G. Price, Rejina Verghis, Peter F. Weller, Peter A. Merkel, Paneez Khoury, on behalf of the EGPA Mepolizumab Open‐Label Extension study group, Arnaud Bourdin, Pascal Chanez, Anoop Chauhan, Vincent Cottin, Gerald Gleich, Berhnard Hellmich, Tomonori Ishii, David Jayne, Jean‐Emmanuel Kahn, Peter Kern, Nader Khalidi, Ina Koetter, Carol Langford, Amy Markezich, Paul Monach, Shamsa Naveed, Peter Oelzner, Kenneth Pinna, Xavier Puechal, Emory H. Robinette, Florence Roufosse, Reinhard Voll, Andrew Schafer, Kaharu Sumino, Masami Taniguchi, Phillip Lieberman   +34 more
wiley   +1 more source

Knowledge and experience regarding perioperative anaphylaxis among anesthesiologists in Istanbul

AIMS Allergy and Immunology, 2017
Anesthesiologists are among the physicians with the highest probability of encountering cases with anaphylaxis. Therefore, they should be familiar with recent developments in anaphylaxis diagnosis and treatment.
Gulben Yakarıca Ergen, Huseyin Erdogan, Filiz Dilek Sirinoğlu, Sibel Oba, Feyzullah Cetinkaya   +4 more
doaj   +1 more source

Association of immune response with efficacy and safety outcomes in adults with phenylketonuria administered pegvaliase in phase 3 clinical trials [PDF]

, 2018
Background: This study assessed the immunogenicity of pegvaliase (recombinant Anabaena variabilis phenylalanine [Phe] ammonia lyase [PAL] conjugated with polyethylene glycol [PEG]) treatment in adults with phenylketonuria (PKU) and its impact on safety ...
Atkinson, John P, Boyer, Ryan, Gu, Zhonghu, Gupta, Soumi, Harding, Cary O, Knight, Vijaya, Larimore, Kevin, Lau, Kelly, Li, Mingjin, Olbertz, Joy, Rosen, Orli, Shepherd, Gillian, Shweighardt, Becky, Weng, Haoling H, Zoog, Stephen J   +14 more
core   +2 more sources

Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

ESC Heart Failure, EarlyView.
Abstract COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis.
Nicolas Hulscher, Roger Hodkinson, William Makis, Peter A. McCullough   +3 more
wiley   +1 more source

Prevalence and management of immediate drug hypersensitivity observed during antineoplastic drug therapy

Acta Oncologica
Background: Immediate drug hypersensitivity reactions (IDHRs) complicate the treatment of patients with cancer. Rapid drug desensitization (RDD) is not a standard treatment option in Northern Europe as in Southern Europe and the US.
Trine Holm Rasmussen, Charlotte Gotthard Mortz, Per Pfeiffer, Nina Andersen, Carsten Bindslev-Jensen   +4 more
doaj   +1 more source

Refractory Anaphylaxis: Data From the European Anaphylaxis Registry

Frontiers in Immunology, 2019
Refractory anaphylaxis (unresponsive to treatment with at least two doses of minimum 300 μg adrenaline) is a rare and often fatal hypersensitivity reaction. Comprehensive data on its definition, prevalence, and risk factors are missing.
Wojciech Francuzik, Sabine Dölle-Bierke, Macarena Knop, Kathrin Scherer Hofmeier, Ewa Cichocka-Jarosz, Blanca E. García, Roland Lang, Ioana Maris, Jean-Marie Renaudin, Margitta Worm   +9 more
doaj   +1 more source

An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis

Science Translational Medicine, 2019
Co-existence of drug-specific IgE and IgG antibodies aggravates neuromuscular-blocking agent-induced anaphylaxis in humans. A shocking contributor in drug-induced anaphylaxis Classic anaphylaxis is thought to depend on IgE engagement of Fc receptors on ...
F. Jönsson, L. de Chaisemartin, V. Granger, A. Gouel-Chéron, Caitlin M. Gillis, Qianqian Zhu, F. Dib, P. Nicaise-Roland, C. Ganneau, M. Hurtado-Nedelec, C. Paugam‐Burtz, Skander Necib, H. Keita-Meyer, M. Le Dorze, B. Cholley, O. Langeron, L. Jacob, B. Plaud, M. Fischler, C. Sauvan, M. Guinnepain, P. Montravers, M. Aubier, S. Bay, C. Neukirch, F. Tubach, D. Longrois, S. Chollet-Martin, P. Bruhns   +28 more
semanticscholar   +1 more source

Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis.

Journal of Clinical Investigation, 2020
No known therapies can prevent anaphylaxis. Bruton's tyrosine kinase (BTK) is an enzyme thought to be essential for high-affinity IgE receptor (FcεRI) signaling in human cells.
M. Dispenza, Rebecca A. Krier-Burris, K. Chhiba, B. Undem, Piper A. Robida, B. Bochner   +5 more
semanticscholar   +1 more source

Exploring the Potential and Advancements of Circular RNA Therapeutics

Exploration, EarlyView.
Given the remarkable advantages in terms of stability, sustained expression profile, safety, wide range of druggable targets, scalable and cost‐effective manufacturing capabilities, circRNA is currently undergoing intensive investigation for various therapeutic applications such as vaccines, protein replacement, genetic disease treatment, gene therapy,
Lei Wang, Lianqing Wang, Chunbo Dong, Jialong Liu, Guoxin Cui, Shan Gao, Zhida Liu   +6 more
wiley   +1 more source

New Perspectives on Polysaccharides From Gracilaria and Gracilariopsis (Rhodophyta) and Their Potential Applications in Future Industries

Food Frontiers, EarlyView.
1. Gracilaria is abundantly available red seaweed that has been used as a traditional medicine and food for years and is rich in nutritional value. 2. Gracilaria polysaccharides are sulfated and have been reported to possess various beneficial biological activities and are widely used in food packaging, food formulation, cosmeceutical products, and ...
Amanda Tresiliana Mulio, Chien‐Shan Chiu, Yung‐Jia Chan, Wen‐Chien Lu, Po‐Hsien Li   +4 more
wiley   +1 more source