Results 71 to 80 of about 109,434 (328)

Prevalence and management of immediate drug hypersensitivity observed during antineoplastic drug therapy

Acta Oncologica
Background: Immediate drug hypersensitivity reactions (IDHRs) complicate the treatment of patients with cancer. Rapid drug desensitization (RDD) is not a standard treatment option in Northern Europe as in Southern Europe and the US.
Trine Holm Rasmussen, Charlotte Gotthard Mortz, Per Pfeiffer, Nina Andersen, Carsten Bindslev-Jensen   +4 more
doaj   +1 more source

Refractory Anaphylaxis: Data From the European Anaphylaxis Registry

Frontiers in Immunology, 2019
Refractory anaphylaxis (unresponsive to treatment with at least two doses of minimum 300 μg adrenaline) is a rare and often fatal hypersensitivity reaction. Comprehensive data on its definition, prevalence, and risk factors are missing.
Wojciech Francuzik, Sabine Dölle-Bierke, Macarena Knop, Kathrin Scherer Hofmeier, Ewa Cichocka-Jarosz, Blanca E. García, Roland Lang, Ioana Maris, Jean-Marie Renaudin, Margitta Worm   +9 more
doaj   +1 more source

The acute and long-term management of anaphylaxis: protocol for a systematic review [PDF]

, 2013
Background:The European Academy of Allergy and Clinical Immunology is in the process of developing its Guideline for Food Allergy and Anaphylaxis, and this systematic review is one of seven inter-linked evidence syntheses that are being undertaken in ...
Antonella Muraro, Aziz Sheikh, Graham Roberts, Margitta Worm, null null, Sangeeta Dhami, Sukhmeet S Panesar, Tamara Rader   +7 more
core   +1 more source

Versatile Enzymatic Approach for Truncation, Labeling, and Mutation of Nucleobase‐Modified Aptamers Demonstrated on Indole‐Modified β‐Conglutin Aptamer

ChemBioChem, EarlyView.
Enzymatic methodology for truncation of base modified aptamers from 3’‐, 5’‐ or 3’‐ and 5’‐ends suitable also for 5’‐labeling or partially mutated versions, is presented and exemplified on a β‐conglutin aptamer containing indole modifications. A new enzymatic method for truncation of aptamers from 5’‐end has been developed and demonstrated on a newly ...
Marek Ondruš, Pablo Alberto Franco‐Urquijo, Teresa Mairal Lerga, Lucie Mužíkova Čechová, M. Carmen Bermudo Redondo, Ciara K. O´Sullivan, Michal Hocek   +6 more
wiley   +1 more source

Knowledge and experience regarding perioperative anaphylaxis among anesthesiologists in Istanbul

AIMS Allergy and Immunology, 2017
Anesthesiologists are among the physicians with the highest probability of encountering cases with anaphylaxis. Therefore, they should be familiar with recent developments in anaphylaxis diagnosis and treatment.
Gulben Yakarıca Ergen, Huseyin Erdogan, Filiz Dilek Sirinoğlu, Sibel Oba, Feyzullah Cetinkaya   +4 more
doaj   +1 more source

A multicenter anaphylaxis registry in Korea: Clinical characteristics and acute treatment details from infants to older adults

World Allergy Organization Journal, 2020
Background: Although the prevalence of anaphylaxis is increasing worldwide, the large-scale studies in Asia evaluating anaphylaxis in all age groups are limited.
Kyunguk Jeong, Young-Min Ye, Sang-Ha Kim, Kyung Won Kim, Jeong Hee Kim, Ji-Won Kwon, Song-I. Yang, So-Yeon Lee, Eun Hee Chung, Mi-Ae Kim, Yoon Hee Kim, Hye-Young Kim, Gwang Cheon Jang, Joo-Hee Kim, Eunjoo Lee, Jihyun Kim, Kangmo Ahn, Yoon-Seok Chang, Gyu-Young Hur, Jeongmin Lee, Taek Ki Min, Bok-Yang Pyun, Kyung Hee Park, Jaechun Lee, Tae Won Song, Hye Mi Jee, Yoo Seob Shin, Dankyu Yoon, Jeom-Kyu Lee, Sooyoung Lee   +29 more
doaj   +1 more source

Safety, Tolerability, and Pharmacokinetics of the Long‐Acting SARS‐CoV‐2–Neutralizing Monoclonal Antibody Combination AZD7442 (Tixagevimab/Cilgavimab) in Healthy Chinese Adults

Clinical Pharmacology in Drug Development, EarlyView.
Abstract AZD7442, a combination of extended half‐life monoclonal antibodies tixagevimab and cilgavimab, was shown to neutralize previously circulating SARS‐CoV‐2 variants. This study evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of AZD7442 in healthy Chinese adults. In this randomized, placebo‐controlled, Phase 1 study, AZD7442
Nanyang Li, Jing Zhang, Wenhong Zhang, Zhongyuan Xu, Xiangcao Yao, Anqi He, Shuyuan Liu, Xiaoyun Ge, Jinxi Liu, Yunfei Li, Cecil Chi‐Keung Chen, Huixia Zhang   +11 more
wiley   +1 more source

Oral food challenge to wheat: a near-fatal anaphylaxis and review of 93 food challenges in children

World Allergy Organization Journal, 2013
Background Wheat allergy is among the most common food allergy in children, but few publications are available assessing the risk of anaphylaxis due to wheat.Methods In this study, we report the case of near-fatal anaphylaxis to wheat in a patient ...
Antonella Cianferoni, Karishma Khullar, Rushani Saltzman, Joel Fiedler, Jackie P Garrett, David R Naimi, Jonathan M Spergel   +6 more
doaj   +1 more source

Safety and Pharmacokinetics of Long‐Acting Monoclonal Antibodies Tixagevimab and Cilgavimab (AZD7442) in a China Phase 2 Study and Evaluation of Asian Race Effect

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Safety, pharmacokinetics, and impact of race of pharmacokinetics on monoclonal antibodies tixagevimab and cilgavimab (AZD7442) were assessed in Chinese adult participants in a Phase 2, randomized, double‐blind, placebo‐controlled trial. In total, 272 participants were randomized 3:1 to a single intravenous dose of 600 mg AZD7442 or placebo and
Jing Zhang, Huixia Zhang, Yajuan Zhang, Shuyuan Liu, Xiaoyun Ge, Haiyue Zhang, Yunfei Li, Cecil Chi‐Keung Chen, Oleg Stepanov, Weifeng Tang, Wenhong Zhang   +10 more
wiley   +1 more source

Implementation of Rapid Drug Desensitization in Antineoplastic Drug Therapy in Denmark Using One‐Bag Protocols

Clinical and Translational Allergy
Background Rapid drug desensitization (RDD) is the cornerstone of managing patients with immediate drug hypersensitivity reactions (IDHR) to antineoplastic drugs in Southern Europe and the United States.
Trine Holm Rasmussen, Charlotte Gotthard Mortz, Per Pfeiffer, Nina Andersen, David George Mawn, Line Kring Tannert, Millie Nguyen Basu, Helene Marlies Rasmussen, Carsten Bindslev‐Jensen   +8 more
doaj   +1 more source