Results 71 to 80 of about 60,111 (283)

IQ Survey Results on Current Industry Practices—Part 1: Immunogenicity Risk Assessment

Clinical Pharmacology &Therapeutics, EarlyView.
An immunogenicity risk assessment (IRA) is a relatively new expectation of health authorities that is increasingly incorporated into the drug development process across the pharmaceutical/biotech industry. The guiding principle for an IRA includes a comprehensive evaluation of product‐ and patient‐related factors that may influence the immunogenic ...
Christine Grimaldi, Susan Richards, Daniel Baltrukonis, Shelley Sims Belouski, Kelly Coble, Sanjay L. Dholakiya, Joanna Grudzinska‐Goebel, Gerry Kolaitis, Jocelyn H. Leu, Linlin Luo, Stephen Lowe, Tao Niu, Henrik Toft‐Hansen, Jianning Yang, Benjamin Wu   +14 more
wiley   +1 more source

Drug‐Event Pairs as Indicators for the Detection of Adverse Drug Reactions during Hospitalization in Routinely Collected Electronic Data Sources

Clinical Pharmacology &Therapeutics, EarlyView.
Adverse drug reactions (ADRs) are a common cause of morbidity and mortality in hospitalized patients. Identification of ADRs in clinical practice, surveillance and research is essential to prevent further harm. The aim of this study was to assess the likelihood of drugs contributing to clinically important inpatient adverse events, in order to provide ...
Anna Maria Wermund, Annette Haerdtlein, Wolfgang Fehrmann, Clara Weglage, Tobias Dreischulte, Ulrich Jaehde   +5 more
wiley   +1 more source

Autopsy findings in cases of fatal COVID‐19 vaccine‐induced myocarditis

ESC Heart Failure, EarlyView.
Abstract COVID‐19 vaccines have been linked to myocarditis, which, in some circumstances, can be fatal. This systematic review aims to investigate potential causal links between COVID‐19 vaccines and death from myocarditis using post‐mortem analysis.
Nicolas Hulscher, Roger Hodkinson, William Makis, Peter A. McCullough   +3 more
wiley   +1 more source

Butyrate alleviates food allergy by improving intestinal barrier integrity through suppressing oxidative stress‐mediated Notch signaling

iMeta, EarlyView.
Compared to healthy controls, children with food‐sensitized tolerance and food allergy showed reduced fecal short‐chain fatty acids (SCFAs), particularly butyrate. In an ovalbumin‐sensitized mouse model, butyrate outperformed other SCFAs in alleviating allergic responses.
Jialu Shi, Wenjun Mao, Yuqing Song, Yuxin Wang, Lili Zhang, Yan Xu, Huiwen Gu, Siyu Yao, Yuanhang Yao, Zhifeng Liu, Vijaya Raghavan, Jin Wang   +11 more
wiley   +1 more source

Some Insects Are More Equal Than Others: A Comparison of Popular Large Language Model Chatbots' Treatment of Different Insect Groups 昆虫间的不平等——主流大语言模型 (LLM) 对不同昆虫评价的比较研究

Integrative Conservation, EarlyView.
Our research demonstrates that in mirroring prevailing human biases towards different insect groups, LLM chatbots oversimplify insect diversity by predominantly restricting “bees” to honeybees and “wasps” to yellowjackets, neglecting the majority of biodiversity that includes wild bees and parasitoid wasps, while also favouring Nearctic species in ...
Marina Moser, Lars Krogmann, Dominic Wanke   +2 more
wiley   +1 more source

Engineered strategies for the allergic disease therapy

Interdisciplinary Medicine, EarlyView.
Allergic diseases exist widely across the globe and now there are very limited therapeutics for the treatment of these diseases. In this review, we summarize the recent advances in engineering strategies including nanoemulsion and hydrogel to improve the therapeutic efficacy of allergen‐specific immunotherapy with decreased side effects and long‐term ...
Yun Tian, Xin Wu, Xiaoqi Sun, Lei Rong, Kai Han   +4 more
wiley   +1 more source

How to manage anaphylaxis in primary care

Clinical and Translational Allergy, 2017
Anaphylaxis is defined as a severe life-threatening generalized or systemic hypersensitivity reaction characterized by rapidly developing airway and/or circulation problems.
Alberto Alvarez-Perea, Luciana Kase Tanno, María L. Baeza   +2 more
doaj   +1 more source

Real‐life retrospective multicentre study to describe the use of dupilumab in paediatric patients with atopic dermatitis in Spain: Patient profile, effectiveness and safety

JEADV Clinical Practice, EarlyView.
Abstract Background Dupilumab, inhibiting interleukin 4 and 13, is the first monoclonal antibody licensed for atopic dermatitis (AD) since 6 months of age. Objectives The study describes the patients' profile, the effectiveness and safety in real life of dupilumab in adolescents with moderate‐severe AD and children with severe AD.
Eulalia Baselga Torres, Marta Ivars, Carolina Prat, Asunción Vicente, Marta Feito Rodríguez, Rocío Maseda Pedrero, Ana Martín Santiago, Aniza Giacaman, Antonio Torrelo Fernández, Lucero Noguera‐Morel, Isabel Betlloch Mas, Laura de Berbegal Gracia, Montserrat Évole Buselli, Mónica Pozuelo Ruiz, José Bernabéu Wittel, María T. Monserrat García, Minia Campos Domínguez, Cristina Galache Osuna, Jorge Santos‐Juanes Jiménez, Altea Esteve Martínez, Violeta Zaragoza Ninet, Miquel Casals Andreu, Sara I. Palencia Pérez, José Suárez Hernández, Sara Dorta Alom, Laura Feliciano Divasson, Ana Batalla Cebey, Manuel Galán Gutiérrez, Raúl de Lucas Laguna   +28 more
wiley   +1 more source

Skin Diseases in Long‐Distance Runners

JEADV Clinical Practice, EarlyView.
ABSTRACT Long‐distance running, including both road running and trail/mountain running, has significantly increased in popularity in recent years. The prolonged, repetitive physical activity combined with environmental exposures predisposes runners to a range of dermatological problems.
Henna Ahomies, Vincent Descamps, Stéphanie Leclerc‐Mercier, Nicolas Kluger   +3 more
wiley   +1 more source

Open and arthroscopic deepening trochleoplasty improves post‐operative outcomes: A systematic review of the literature reveals lack of comparability between techniques

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose Deepening trochleoplasty improves outcomes in patients with trochlear dysplasia. The aim of this systematic review was to present the outcomes after open thin‐flap, open thick‐flap and arthroscopic deepening trochleoplasty. Methods A systematic review was conducted using the PRISMA guidelines.
Signe Høj, Johanne Kofoed Lundegaard, Lars Blønd, Peter Lavard, Anke Simone Rechter, Christian Dippmann, Kristoffer W. Barfod   +6 more
wiley   +1 more source