Results 61 to 70 of about 64,244 (297)

Navigating adverse immunostimulation: A practical guide for clinical researchers

British Journal of Clinical Pharmacology, EarlyView.
Problem Setting As drug development moves towards more complex products, early clinical development programmes are increasingly hampered by unwanted and/or unexpected activation of the immune system (adverse immune stimulation, AIS). Solution At the Centre for Human Drug Research, we have introduced standardized procedures to make AIS manageable, while
Juliette A. van den Noort, Anouk C. Meijs, Naomi B. Klarenbeek, Matthijs Moerland   +3 more
wiley   +1 more source

Comparison of anaphylaxis epidemiology between urban and suburban pediatric emergency departments

BMC Pediatrics, 2023
Background Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death. To date, there are no published data on epidemiology of pediatric anaphylaxis in Michigan.
Dhritiman Gurkha, Robert Podolsky, Usha Sethuraman, Kelly Levasseur   +3 more
doaj   +1 more source

Efficacy and safety of empagliflozin for treating neutropenia and neutrophil dysfunction in paediatric patients with glycogen storage disease type Ib: A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Glycogen storage disease type Ib (GSD‐Ib) is a rare genetic disorder causing neutropenia and neutrophil dysfunction in children. G‐CSF has been the primary treatment, but emerging data support the potential of empagliflozin, an SGLT2 inhibitor, as a promising investigational option.
Elizabeth Iwasyk, Ryan Jin, Fabio Tuzzolino, Giusy Ranucci, Donatella Madonia, Alessio Provenzani   +5 more
wiley   +1 more source

Oral food challenge to wheat: a near-fatal anaphylaxis and review of 93 food challenges in children

World Allergy Organization Journal, 2013
Background Wheat allergy is among the most common food allergy in children, but few publications are available assessing the risk of anaphylaxis due to wheat.Methods In this study, we report the case of near-fatal anaphylaxis to wheat in a patient ...
Antonella Cianferoni, Karishma Khullar, Rushani Saltzman, Joel Fiedler, Jackie P Garrett, David R Naimi, Jonathan M Spergel   +6 more
doaj   +1 more source

A multicenter anaphylaxis registry in Korea: Clinical characteristics and acute treatment details from infants to older adults

World Allergy Organization Journal, 2020
Background: Although the prevalence of anaphylaxis is increasing worldwide, the large-scale studies in Asia evaluating anaphylaxis in all age groups are limited.
Kyunguk Jeong, Young-Min Ye, Sang-Ha Kim, Kyung Won Kim, Jeong Hee Kim, Ji-Won Kwon, Song-I. Yang, So-Yeon Lee, Eun Hee Chung, Mi-Ae Kim, Yoon Hee Kim, Hye-Young Kim, Gwang Cheon Jang, Joo-Hee Kim, Eunjoo Lee, Jihyun Kim, Kangmo Ahn, Yoon-Seok Chang, Gyu-Young Hur, Jeongmin Lee, Taek Ki Min, Bok-Yang Pyun, Kyung Hee Park, Jaechun Lee, Tae Won Song, Hye Mi Jee, Yoo Seob Shin, Dankyu Yoon, Jeom-Kyu Lee, Sooyoung Lee   +29 more
doaj   +1 more source

An IgG-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis [PDF]

, 2019
International audienceAnaphylaxis is a systemic acute hypersensitivity reaction that is considered to depend on allergen-specific immunoglobulin E (IgE) antibodies and histamine release by mast cells and basophils.
Gouel-Chéron, A, Bay, Sylvie, Tubach, F, Christelle Ganneau, Plaud, Benoît, Longrois, D, Guinnepain, M-T, Bruhns, P, Cholley, B, Bay, S, Guinnepain, Marie-Therese, Aubier, M, Caitlin M. Gillis, Matthieu Le Dorze, Sylvie Bay, Zhu, Q, Granger, V, Cholley, Bernard, Plaud, B, Marc Fischler, Longrois, Dan, Paugam-Burtz, C, Zhu, Qianqian, Hawa Keita-Meyer, Fischler, M, Dan Longrois, De Chaisemartin, Luc, Gouel-Chéron, Aurélie, Langeron, O, Hurtado-Nedelec, Maria, Luc de Chaisemartin, Dib, F, Caroline Sauvan, Gillis, Caitlin, Dib, Fadia, Catherine Neukirch, Montravers, P, Maria Hurtado-Nedelec, Skander Necib, Gillis, CM, Sylvie Chollet-Martin, Jacob, L, Bernard Cholley, Philippe Montravers, Pierre Bruhns, Olivier Langeron, Tubach, Florence, Granger, Vanessa, Qianqian Zhu, Jönsson, F, Ganneau, Christelle, Montravers, Philippe, Laurent Jacob, Paugam-Burtz, Catherine, Le Dorze, Matthieu, Chollet-Martin, Sylvie, Jönsson, Friederike, Aubier, Michel, Jacob, Laurent, Le Dorze, M, Fischler, Marc, Neukirch, C, Nicaise-Roland, Pascale, Marie-Thérèse Guinnepain, Bruhns, Pierre, de Chaisemartin, L, Florence Tubach, Neukirch, Catherine, Friederike Jönsson, Necib, Skander, Langeron, Olivier, Keita-Meyer, H, Vanessa Granger, Benoit Plaud, Hurtado-Nedelec, M, Aurélie Gouel-Chéron, Sauvan, Caroline, Pascale Nicaise-Roland, Necib, S, Nicaise-Roland, P, Ganneau, C, Sauvan, C, Fadia Dib, Catherine Paugam-Burtz, Keita-Meyer, Hawa, Chollet-Martin, S, Michel Aubier   +86 more
core   +2 more sources

Efficacy, safety and cost‐effectiveness of CAR‐T therapy

British Journal of Clinical Pharmacology, EarlyView.
CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher, Amina Džidić‐Krivić, Emma Pinjic, Nejra Selak, Kanita Omerbasic, Alexandar Chupin, Andrej Belancic, Almir Fajkic   +7 more
wiley   +1 more source

Interim considerations : Preparing for the potential management of anaphylaxis after COVID-19 vaccination [PDF]

A serious allergic reaction (e.g., anaphylaxis) after a previous dose or to a component of a COVID-19 vaccine or an immediate allergic reaction of any severity after a previous dose or known (diagnosed) allergy to a component of a COVID-19 vaccine are ...

core   +3 more sources

Prevalence and management of immediate drug hypersensitivity observed during antineoplastic drug therapy

Acta Oncologica
Background: Immediate drug hypersensitivity reactions (IDHRs) complicate the treatment of patients with cancer. Rapid drug desensitization (RDD) is not a standard treatment option in Northern Europe as in Southern Europe and the US.
Trine Holm Rasmussen, Charlotte Gotthard Mortz, Per Pfeiffer, Nina Andersen, Carsten Bindslev-Jensen   +4 more
doaj   +1 more source

Food allergy and anaphylaxis [PDF]

, 2018
David Yue, Amanda Ciccolini, Ernie Avilla, Susan Waserman Division of Clinical Immunology & Allergy, Department of Medicine, Health Sciences Centre, McMaster University, Hamilton, ON, Canada Abstract: Anaphylaxis is a severe and potentially life ...
Yue D, Waserman S, Ciccolini A, Avilla E
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