Results 51 to 60 of about 47,907 (235)

Anaplastic large cell lymphoma in paediatric and young adult patients. [PDF]

, 2016
Anaplastic large cell lymphoma (ALCL) is a heterogeneous disease of debateable origin that, in children, is largely anaplastic lymphoma kinase (ALK) positive with aberrant ALK activity induced following the formation of chromosomal translocations. Whilst
Agnelli, Ait-Tahar, Ait-Tahar, Alexander, Ambrogio, Bai, Bai, Bartlett, Benharroch, Bonzheim, Brugieres, Brugieres, Brugieres, Brugieres, Chiarle, Chiarle, Cools, Crescenzo, Damm-Welk, Damm-Welk, Deley, Deley, Duvic, Elias, Eyre, Falini, Falini, Fanale, Feldman, Feldman, Gambacorti Passerini, Gambacorti Passerini, Gascoyne, Hanahan, Hoareau-Aveilla, Hoch, Katayama, Kempf, Kenner, Kinney, Laimer, Laly, Lamant, Lamant, Lamant, Lamant, Laurent, Laurent, Laver, Leventaki, Liang, Lowe, Malcolm, Marzec, Marzec, Marzec, Mason, McDonnell, Merkel, Merkel, Mori, Morris, Mosse, Moti, Mussolin, Mussolin, Parrilla Castellar, Passoni, Passoni, Pileri, Pro, Pulford, Raica, Richly, Rolland, Rosenwald, Rosolen, Ruf, Salaverria, Savage, Schmitz, Seidemann, Sibon, Slupianek, Stein, Suzuki, Swerdlow, Tanaka, Tanaka, Tort, Touriol, Trinei, Turner, Turner, Vasmatzis, Vassallo, Wencker, Willemze, Williams, Williams, Woessmann, Woessmann, Wrobel, Ye, Youssif, Zhang, Zhang   +106 more
core   +1 more source

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Anaplastic large T-cell lymphoma: 10-year experience at the National Institute of Neoplastic Diseases, Lima – Peru

Revista de la Facultad de Medicina Humana, 2022
Introduction: Anaplastic Large T-Cell Lymphoma is an infrequent pathology, determined by the expression of CD30, with different characteristics in its presentation and being more aggressive according to the expression of ALK.
Cristian Pacheco, Monica Calderon, Carlos Barrionuevo Cornejo, Henry Gomez Moreno   +3 more
doaj   +1 more source

A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation. [PDF]

, 2014
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a relatively good prognosis, aggressive forms exist. We have identified a novel translocation, causing the fusion of the TRAF1 and ALK genes, in one patient ...
...], Abate, F., Abele, C., Acquaviva, A., Agostinelli, C., Aime, S., Aliberti, S., Barreca, A., Bertoni, F., Bessone, L., Boi, M., Cerchietti, L., Chan, W.C., Cheng, M., Crescenzo, R., Di Giacomo, F., Falini, B., Ficarra, E., Gaudiano, M., Inghirami, G., Iqbal, J., Kwee, I., Landra, I., Lasorsa, E., Longo, D.L., Machiorlatti, R., Messana, K., Novero, D., Pera-Gresely, B., Piccaluga, P.P., Pileri, S., Piva, R., Ponzoni, M., Rabadan, R., Rinaldi, A., Ruggeri, B., Shultz, L.D., Tabb\uf2, F., The European T-cell Lymphoma Study Group [..., Tiacci, E., Todaro, M., Tousseyn, T., Van Der Krogt, J.-A., Wlodarska, I.   +43 more
core   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Genetics of anaplastic large cell lymphoma [PDF]

Leukemia & Lymphoma, 2015
Anaplastic large cell lymphoma (ALCL) comprises a group of T-cell non-Hodgkin lymphomas unified by common morphologic and immunophenotypic characteristics, but with a spectrum of clinical presentations and behaviors. Early identification of anaplastic lymphoma kinase (ALK) gene rearrangements in some ALCLs led to recognition of ALK as an important ...
Yu, Zeng, Andrew L, Feldman
openaire   +2 more sources

Analysis of SWI Complex Subunits in 69 Cases of TTF‐1 Negative Non‐Small Cell Lung Carcinoma

Diagnostic Cytopathology, EarlyView.
ABSTRACT Non‐small cell lung carcinomas, not otherwise specified (NSCLC‐NOS) with a specific signature including high‐grade hepatoid/clear cell morphology, negative lung panel mutational analysis, negative TTF‐1/Napsin A staining can be reported as a morphologic variant of an aggressive carcinoma with loss of one of the subunits of the SWI/SNF ...
Ramin Zargham, Feng (Selina) Ji, Tarek Bismar   +2 more
wiley   +1 more source

Sister Mary Joseph's Nodule at a University Teaching Hospital in Northwestern Tanzania: A Retrospective Review of 34 cases. [PDF]

, 2013
Sister Mary Joseph's nodule is a metastatic tumor deposit in the umbilicus and often represents advanced intra-abdominal malignancy with dismal prognosis. There is a paucity of published data on this subject in our setting.
A Dubreuil, AB Clements, AJ Khan, B Majmudar, B Piura, C Tam, D Calista, D Trebing, E Kolwijck, F Al-Mashat, F Panaro, FC Powell, H Bailey, H Bank, IS Schwartz, JJ Horn, JL O'Leary, Joseph B. Mabula, JP Touraud, M Falchi, M Yusuf, Mabula D. Mchembe, MR Shetty, MV Barrow, Peter F. Rambau, Phillipo L. Chalya, R Amaro, R Gabriele, R Gabriele, RA Shwartz, RS Goodheart, SN Chatterjee, V Charoenkul, V Schneider, VG Galva, WD Steck   +35 more
core   +1 more source

Dupilumab and Systemic Hematologic Malignancies: Case Series and Literature Review

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting 15%–20% of children and 3%–10% of adults. An increased risk of systemic lymphomas – but not leukemias – has been reported in patients with AD. Dupilumab, a monoclonal IgG4 antibody targeting IL‐4 and IL‐13 signaling, is approved for moderate‐to‐severe AD and is ...
Nello Tommasino, Cataldo Patruno, Francesca di Vico, Maddalena Napolitano   +3 more
wiley   +1 more source