Results 111 to 120 of about 686,182 (220)

Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis

, 2013
PURPOSE OF REVIEW: Anaplastic large cell lymphomas (ALCLs) are rare entities whose somatic genetic lesions have been identified only in a subset of patients.
Tabbo Fabrizio, Falini Brunangelo, Boi Michela, Besson Luca, Lasorsa Elena, Scarfo Irene, Tiacci Enrico, Piva Roberto, Acquaviva Andrea, Pellegrino Elisa, Landra Indira, PICCALUGA, PIER PAOLO, PILERI, STEFANO, Crescenzo Ramona, Pich Achille, Urigu Susanna, Giorgio Inghirami European T. cell Lymphoma Study Group, Mereu Elisabetta, Inghirami Giorgio, Stella Carmelo, Aliberti Sabrina, AGOSTINELLI, CLAUDIO, Gaudiano Marcello, Ubezzi Ivana, Fabrizio Tabbò, Spaccarotella Elisa, Raul Rabadan, Bertoni Francesco, Francesco Bertoni, Abage Francesco, Kwee Ivo, Barreca Antonella, Machiorlatti Rodolfo, Novero Domenico, Vittone Francesco, Todaro Maria, Ficarra Elisa, Di Giacomo Filomena, Messana Katia, Maurilio Ponzoni, Ponzoni Maurilio   +40 more
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ALK-driven tumors and targeted therapy: focus on crizotinib

Pharmacogenomics and Personalized Medicine, 2014
Carlos Murga-Zamalloa, Megan S Lim Department of Pathology, University of Michigan, Ann Arbor, MI, USA Abstract: Receptor tyrosine kinases have emerged as promising therapeutic targets for a diverse set of tumors.
Murga-Zamalloa C, Lim MS
doaj  

Anaplastic lymphoma kinase gene expression in small round cell tumors of childhood-a comparative immunohistochemical study

, 2015
The focus of this study was to investigate anaplastic lymphoma kinase (ALK) expression by immunohistochemistry using a highly specific antibody. Distribution and frequency of ALK expression may provide a clue for ALK inhibitor use in small round cell ...
Demir, Haci Ahmet, Karakus, Esra, Kacar, Ayper, KARAKUŞ, RESUL, Ozyoruk, Derya, Emir, Suna   +5 more
core   +1 more source

PRIMARY CUTANEOUS ANAPLASTIC LARGE CELL LYMPHOMA

, 2010
Anaplastic large cell lymphoma (ALCL) is characterized by proliferation of anaplastic large CD 30+ T-cell lymphoid cells with abundant cytoplasm. Primary cutaneous ALCL is a rare form of ALCL, usually seen in elderly patients. In this report, the authors
ORHAN, DİCLEHAN, Ghania Daar, Bilgehan Yalçın, Vural Kesik, Diclehan Orhan, Münevver Büyükpamukçu, Daar, Ghania, Serhan Küpeli, YALÇIN, BİLGEHAN, Kesik, Vural, BÜYÜKPAMUKÇU, MÜNEVVER, KÜPELİ, SERHAN   +11 more
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Anaplastic lymphoma kinase-positive large B-cell lymphoma: A potential diagnostic pitfall

, 2015
Anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK + LBCL) is a rare variant of LBCL with an abnormal immunophenotype, which is easily misdiagnosed as carcinoma or plasma cell neoplasm.
Mei Lin, Hong Yu, Junxing Huang, Juanjuan Sun, Hui Li, Chaofu Wang   +5 more
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Anaplastic lymphoma kinase immunocytochemistry in fine needle aspiration diagnosis of anaplastic large-cell lymphoma

, 2018
Background: Anaplastic large-cell lymphoma (ALCL) is a rare subtype of non-Hodgkin's lymphoma (NHL) characterized by the presence of unusual giant cells.
Deepali Jain, Venkateswaran K Iyer, Sandeep R Mathur, Prashant Ramteke, Sanjeev Chitragar, Saumyaranjan Mallick, Ashok Singh   +6 more
core   +1 more source

p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.

, 2005
Translocations of the anaplastic lymphoma kinase (ALK) gene have been described in anaplastic large-cell lymphomas (ALCLs) and in stromal tumors. The most frequent translocation, t(2;5), generates the fusion protein nucleophosmin (NPM)-ALK with intrinsic
Riera, L, Tarone, G, Mohammed, Shabaz, Shabaz Mohammed, Guido Tarone, Roberto Chiarle, Claudia Voena, Defilippi, Paola, Giorgio Palestro, Piva, R, Defilippi, P, Elisabetta Boeri Erba, Ambrogio, C, Ludovica Riera, Chiara Ambrogio, Carlotta Costa, Tarone, Guido, Hirsch, Emilio, Manazza, AD, Inghirami, G, Ole N. Jensen, Ambrogio, Chiara, Voena, C, fl., m., Mohammed, S, Erba, Elisabetta Boeri, Barberis, L, Emilio Hirsch, Piva, Roberto, Boeri Erba, E, Giorgio Inghirami, Hirsch, E, Roberto Piva, Voena, Claudia, Palestro, G, Costa, Carlotta, Barberis, Laura, Costa, C, Jensen, Ole Nørregaard; id_orcid, Chiarle, R, Manazza, Andrea D., Jensen, ON, Andrea D. Manazza, Laura Barberis, Paola Defilippi, Riera, Ludovica   +45 more
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Efficacy and safety of crizotinib in patients with anaplastic lymphoma kinase-positive advanced-stage non-small-cell lung cancer

, 2018
Ahmed Mohieldin,1,2 Ayman Rasmy,1,3,4 Mohamed Ashour,2,5 Muath Al-Nassar,6 Rola H Ali,7,8 Fahad G El-Enezi6 1Medical Oncology, Zagazig University Hospitals, Zagazig, Egypt; 2Medical Oncology Department, Sheikha Badriya Alsabah Centre, Kuwait Cancer ...
El-Enezi FG, Ali RH, Ashour M, Mohieldin A, Rasmy A, Al-Nassar M   +5 more
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PAX-5 Positivity in Anaplastic Lymphoma Kinase–Negative Anaplastic Large Cell Lymphoma: A Case Report and Review of Literature

, 2016
Anaplastic lymphoma kinase (ALK)–negative anaplastic large cell lymphoma (ALCL) is a subtype of T-cell lymphomas that may mimic several other malignancies morphologically. With the help of immunohistochemistry, most cases of ALCL can be diagnosed on the
Paromita Roy, Neeraj Arora, Mammen Chandy, Indu Arun, Saurabh Jayant Bhave, Reena Nair   +5 more
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Targeting Anaplastic Lymphoma Kinase in Lung Cancer

, 2011
Several decades of cancer research have revealed a pivotal role for tyrosine kinases as key regulators of signaling pathways, controlling cell growth and differentiation.
Alice T. Shaw, Benjamin Solomon
core   +1 more source