Results 11 to 20 of about 686,182 (220)

Developments in anaplastic large-cell lymphoma: targeting the anaplastic lymphoma kinase

Blood and Lymphatic Cancer: Targets and Therapy, 2014
Francesca Farina, Alessandra Stasia, Carlo Gambacorti-Passerini Department of Health Sciences, University of Milano Bicocca, Monza, Italy Abstract: Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase protein implicated in a variety of ...
Farina F, Stasia A, Gambacorti-Passerini C   +2 more
doaj   +6 more sources

ALK (anaplastic lymphoma kinase) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2010
Review on ALK (anaplastic lymphoma kinase), with data on DNA, on the protein encoded, and where the gene is implicated.
JL Huret, S Senon
core   +9 more sources

Anaplastic lymphoma kinase in human cancer [PDF]

Journal of Molecular Endocrinology, 2011
The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)–ALK chimera ...
Barreca A., Lasorsa E., Riera L., Machiorlatti R., Piva R., Ponzoni M., Kwee I., Bertoni F., Piccaluga P. P., Pileri S. A., Inghirami G., CHILOSI, Marco, ZAMO', Alberto   +12 more
openaire   +5 more sources

Leukemic phase of anaplastic lymphoma kinase positive, anaplastic large cell lymphoma

Indian Journal of Pathology and Microbiology, 2011
Anaplastic large cell lymphoma (ALCL) is a distinct type of CD30+ T/null-cell non-Hodgkin′s lymphoma that frequently involves nodal and extranodal sites.
Vijaya S Gadage, P G Subramanian, Komal S Galani, Kunal K Sehgal, Sachin P Johari, Vijay S Ghogale, Y Badrinath, K Ashok, Sumeet Gujral   +8 more
doaj   +3 more sources

Anaplastic lymphoma kinase positive variant of anaplastic large cell lymphoma: A rare entity [PDF]

Journal of Indian Academy of Oral Medicine and Radiology, 2014
Anaplastic large cell lymphoma (ALCL) is a distinct clinicopathological entity of non-Hodgkin′s lymphoma, which has been included as a T-cell neoplasm in the World Health Organization classification, with peculiar features such as painless ...
Venkata Satya Ramesh Thummala, Sreenidhi Banda, Vinay Kumar Reddy Kundoor, Kotya Naik Maloth   +3 more
doaj   +2 more sources

Crizotinib as a personalized alternative for targeted anaplastic lymphoma kinase rearrangement in previously treated patients with non-small-cell lung cancer

Drug Design, Development and Therapy, 2015
Liting Guo,1,* Haijun Zhang,1,* Weiwei Shao,2 Baoan Chen1 1Department of Hematology and Oncology (Key Department of Jiangsu Medicine), The Affiliated Zhongda Hospital, Medical School of Southeast University, Nanjing, 2Department of Pathology, the First ...
Guo L, Zhang H, Shao W, Chen B
doaj   +1 more source

Role and targeting of anaplastic lymphoma kinase in cancer

Molecular Cancer, 2018
Anaplastic lymphoma kinase (ALK) gene activation is involved in the carcinogenesis process of several human cancers such as anaplastic large cell lymphoma, lung cancer, inflammatory myofibroblastic tumors and neuroblastoma, as a consequence of fusion ...
Carminia Maria Della Corte, Giuseppe Viscardi, Raimondo Di Liello, Morena Fasano, Erika Martinelli, Teresa Troiani, Fortunato Ciardiello, Floriana Morgillo   +7 more
doaj   +2 more sources

Anaplastic Lymphoma Kinase-Positive Anaplastic Large Cell Lymphoma with Cardiac Metastasis and Arterial Tumor Embolisms during First-Course Chemotherapy

Case Reports in Oncology, 2016
We described an 11-year-old boy suffering from pediatric anaplastic lymphoma kinase-positive anaplastic large cell lymphoma with heart metastasis at diagnosis and arterial tumor embolisms during chemotherapy.
Kozo Nagai, Yukari Suyama, Daisuke Koga, Masanori Nishi, Chiaki Iida, Katsuya Tashiro, Atsushi Danjo, Keita Kai, Muneaki Matsuo   +8 more
doaj   +2 more sources

Atypical Presentation of Anaplastic Lymphoma Kinase–Positive Anaplastic Large T-Cell Lymphoma in a Young Patient With Intramuscular Nodules

Annals of Internal Medicine: Clinical Cases
Anaplastic lymphoma kinase–positive anaplastic large cell lymphoma (ALK+ ALCL) is a rare subtype of T-cell non-Hodgkin lymphoma. It commonly presents at advanced stages with B symptoms and lymphadenopathy.
Megan E. Kelley, Nicholas Joseph DeLuca, Daniel Del Castillo Rix, Jonathan H. Schatz, Rafael E. Hernandez Oquet   +4 more
doaj   +2 more sources

Targeting anaplastic lymphoma kinase in neuroblastoma [PDF]

APMIS, 2019
Over the last decade, anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase (RTK), has been identified as a fusion partner in a diverse variety of translocation events resulting in oncogenic signaling in many different cancer types. In tumors where the full‐length ALK RTK itself is mutated, such as neuroblastoma, the picture regarding the role ...
Umapathy, Ganesh, Mendoza‐Garcia, Patricia, Hallberg, Bengt, Palmer, Ruth H.   +3 more
openaire   +2 more sources