Anaplastic Lymphoma Kinase-Negative Anaplastic Large Cell Lymphoma with Colon Involvement [PDF]
1Department of Gastroenterology and Hepatology; 2Department of Pathology, National Hospital Organization, Osaka National Hospital, Osaka, Japan Correspondence and reprints: Dr Yuko Sakakibara, Department of Gastroenterology and Hepatology, National Hospital Organization, Osaka National Hospital, 2-1-14 Houenzaka, Chuo-ku, Osaka city, Osaka 540-0006 ...
Yuko Sakakibara +9 more
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Anaplastic lymphoma kinase status in rhabdomyosarcomas [PDF]
Rhabdomyosarcoma is a rare soft tissue sarcoma that typically affects children, adolescents, and young adults. Despite treatment via a multidisciplinary approach, the prognosis of advance-stage rhabdomyosarcomas remains poor, and a new treatment strategy is needed.
Akihiko, Yoshida +8 more
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How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase? [PDF]
Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently ...
Lee, Christian +4 more
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Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens. [PDF]
Peripheral T-cell lymphomas (PTCL) are generally less common and pursue a more aggressive clinical course than B-cell lymphomas, with the T-cell phenotype itself being a poor prognostic factor in adult non-Hodgkin lymphoma (NHL).
Graham P. Collins +34 more
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Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis [PDF]
The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of analyzing its rare neoplastic lymphocytic and histiocytic (L&H ...
Tiacci, Enrico +29 more
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Primary nodal peripheral T-cell lymphomas: diagnosis and therapeutic considerations
Nodal peripheral T-cell lymphomas are a rare group of neoplasms derived from post-thymic and activated T lymphocytes. A review of scientific articles listed in PubMed, Lilacs, and the Cochrane Library databases was performed using the term "peripheral T ...
Luis Alberto de Pádua Covas Lage +6 more
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ALK1-Negative Anaplastic Large Cell Lymphoma of the Breast from a Nonprosthesis Cyst
Summary: Anaplastic large cell lymphoma of the breast is a rare malignancy associated with prosthetic breast implants. We present a case of a woman with no prior history of breast implants who developed anaplastic lymphoma kinase-1 negative anaplastic ...
Christopher Mulligan, MBBS +5 more
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Anaplastic large cell lymphoma (ALCL) is an uncommon disease, accounting for
Anjali Narwal +3 more
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Background The role of β-catenin in cancer has been most studied in tumors of epithelial cell origin. The functional status and biological significance of this protein in anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma is unknown.
Mona Anand, Raymond Lai, Pascal Gelebart
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Holistic View of ALK TKI Resistance in ALK-Positive Anaplastic Large Cell Lymphoma
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase expressed at early stages of normal development and in various cancers including ALK-positive anaplastic large cell lymphoma (ALK+ ALCL), in which it is the main therapeutic target.
Yuan Wang +11 more
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