Results 21 to 30 of about 42,587 (212)

Advances in target therapy in lung cancer [PDF]

European Respiratory Review, 2015
Herein, we have reviewed and analysed recent literature, published in 2013 and early 2014, in the context of pre-existing data. Considered target therapies were tyrosine kinase inhibitors of active epidermal growth factor receptor mutations (e.g ...
Jean-Paul Sculier, Thierry Berghmans, Anne-Pascale Meert   +2 more
doaj   +1 more source

Successful role of adjuvant radiotherapy in a rare case of tracheal inflammatory myofibroblastic tumor: a case report [PDF]

, 2019
BACKGROUND:: Inflammatory myofibroblastic tumor (IMT) is a rare benign cancer that can express a more aggressive phenotype related to the genetic mutation of the anaplastic lymphoma kinase receptor (ALK). Involvement of trachea is extremely rare and due
Abate, Gessica, Bulzonetti, Nadia, D’Urso, Pasqualina, Lisi, Roberto, Marampon, Francesco, Martinetti, Maria Teresa, Siniscalchi, Benedetta, Tombolini, Vincenzo   +7 more
core   +1 more source

ALK1-Negative Anaplastic Large Cell Lymphoma of the Breast from a Nonprosthesis Cyst

Plastic and Reconstructive Surgery, Global Open, 2014
Summary: Anaplastic large cell lymphoma of the breast is a rare malignancy associated with prosthetic breast implants. We present a case of a woman with no prior history of breast implants who developed anaplastic lymphoma kinase-1 negative anaplastic ...
Christopher Mulligan, MBBS, Elizabeth Salisbury, MBBS, Mark Tschuchnigg, MBBS, Pouria Moradi, MBBS, Alexander Matthews, MBBS, Sanjay Warrier, MBBS   +5 more
doaj   +1 more source

Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer. [PDF]

, 2017
Anaplastic lymphoma kinase (ALK) gene rearrangements have been identified in lung cancer at 3-7% frequency, thus representing an important subset of genetic lesions that drive oncogenesis in this disease. Despite the availability of multiple FDA-approved
Bivona, Trever G, Haderk, Franziska, Wu, Wei   +2 more
core   +3 more sources

microRNA. Diagnostic Perspective [PDF]

, 2015
Biomarkers are biological measures of a biological state. An ideal marker should be safe and easy to measure, cost efficient, modifiable with treatment, and consistent across gender and ethnic groups. To date, none of the available biomarkers satisfy all
FARUQ, MD OMAR, VECCHIONE, ANDREA
core   +2 more sources

Anaplastic lymphoma kinase negative anaplastic large cell lymphoma of hard palate as first clinical manifestation of acquired immune deficiency syndrome

Contemporary Clinical Dentistry, 2016
Anaplastic large cell lymphoma (ALCL) is an uncommon disease, accounting for
Anjali Narwal, Achla Bharti Yadav, Sant Prakash, Shally Gupta   +3 more
doaj   +1 more source

How does conformational flexibility influence key structural features involved in activation of anaplastic lymphoma kinase? [PDF]

, 2014
Anaplastic Lymphoma Kinase (ALK) plays a major role in developing tumor processes and therefore has emerged as a validated therapeutic target. Applying atomistic molecular dynamics simulations on the wild type enzyme and the nine most frequently ...
Adcock, Berendesen, Berendsen, Berman, Bossi, Chen, Christian C. Lee, Christo Z. Christov, Christov, Epstein, Essmann, Gary W. Black, George, Glowacki, Hess, Karplus, Karplus, Kruschel, Lee, Lodola, Morris, Mosse, Rodriguez, Roskoski Jr., Rossen Donev, Schuttelkopf, Sun, Tabbo, Tatyana G. Karabencheva   +28 more
core   +1 more source

Primary gastric anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma

OncoTargets and Therapy, 2016
Most primary stomach lymphomas are now recognized to originate from B-cell. Primary gastric anaplastic lymphoma kinase (ALK)-negative anaplastic large-cell lymphoma (ALCL) as shown in this case is very rare.A 59-year-old man presented with a 1-month history of epigastric pain.
Tian, Chen, Zhang,Yizhuo
openaire   +4 more sources

β-catenin is constitutively active and increases STAT3 expression/activation in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma

Haematologica, 2011
Background The role of β-catenin in cancer has been most studied in tumors of epithelial cell origin. The functional status and biological significance of this protein in anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma is unknown.
Mona Anand, Raymond Lai, Pascal Gelebart
doaj   +1 more source

Anaplastic large cell lymphoma in paediatric and young adult patients. [PDF]

, 2016
Anaplastic large cell lymphoma (ALCL) is a heterogeneous disease of debateable origin that, in children, is largely anaplastic lymphoma kinase (ALK) positive with aberrant ALK activity induced following the formation of chromosomal translocations. Whilst
Agnelli, Ait-Tahar, Ait-Tahar, Alexander, Ambrogio, Bai, Bai, Bartlett, Benharroch, Bonzheim, Brugieres, Brugieres, Brugieres, Brugieres, Chiarle, Chiarle, Cools, Crescenzo, Damm-Welk, Damm-Welk, Deley, Deley, Duvic, Elias, Eyre, Falini, Falini, Fanale, Feldman, Feldman, Gambacorti Passerini, Gambacorti Passerini, Gascoyne, Hanahan, Hoareau-Aveilla, Hoch, Katayama, Kempf, Kenner, Kinney, Laimer, Laly, Lamant, Lamant, Lamant, Lamant, Laurent, Laurent, Laver, Leventaki, Liang, Lowe, Malcolm, Marzec, Marzec, Marzec, Mason, McDonnell, Merkel, Merkel, Mori, Morris, Mosse, Moti, Mussolin, Mussolin, Parrilla Castellar, Passoni, Passoni, Pileri, Pro, Pulford, Raica, Richly, Rolland, Rosenwald, Rosolen, Ruf, Salaverria, Savage, Schmitz, Seidemann, Sibon, Slupianek, Stein, Suzuki, Swerdlow, Tanaka, Tanaka, Tort, Touriol, Trinei, Turner, Turner, Vasmatzis, Vassallo, Wencker, Willemze, Williams, Williams, Woessmann, Woessmann, Wrobel, Ye, Youssif, Zhang, Zhang   +106 more
core   +1 more source