Results 41 to 50 of about 42,587 (212)

Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors [PDF]

, 2011
A series of novel 3,5-diamino-1,2,4-triazole benzyl ureas was identified as having potent anaplastic lymphoma kinase (ALK) inhibition exemplified by 15a, 20a, and 23a, which exhibited antiproliferative IC50 values of 70, 40, and 20 nM in Tel-ALK ...
Deng, Xianming, George, Rani E., Gray, Nathanael Schiander, Jänne, Pasi A., Kim, Nam Doo, Luther, William, Sasaki, Takaaki, Sim, Taebo, Wang, Jinhua, Zhang, Jianming   +9 more
core   +2 more sources

ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature

Autopsy and Case Reports, 2021
Cardiac lymphoma is a rare entity. In this setting, the secondary involvement of the heart is far more frequent than the primary cardiac lymphoma. Herein, we present an autopsy case of a disseminated anaplastic lymphoma kinase (ALK)- positive anaplastic ...
Kaniyappan Nambiyar, Kirti Gupta, Uma Debi, Saroj Kant Sinha, Rakesh Kochhar   +4 more
doaj  

Blockade of crizotinib-induced BCL2 elevation in ALK-positive anaplastic large cell lymphoma triggers autophagy associated with cell death

Haematologica, 2019
Anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphomas are tumors that carry translocations involving the ALK gene at the 2p23 locus, leading to the expression of ALK tyrosine kinase fusion oncoproteins.
Avedis Torossian, Nicolas Broin, Julie Frentzel, Camille Daugrois, Sarah Gandarillas, Talal Al Saati, Laurence Lamant, Pierre Brousset, Sylvie Giuriato, Estelle Espinos   +9 more
doaj   +1 more source

Crizotinib-induced antitumour activity in human alveolar rhabdomyosarcoma cells is not solely dependent on ALK and MET inhibition [PDF]

, 2015
BACKGROUND: Rhabdomyosarcoma (RMS) is the most commonly diagnosed malignant soft tissue tumour in children and adolescents. Aberrant expression of Anaplastic Lymphoma Kinase (ALK) and MET gene has been implicated in the malignant progression of RMS ...
CAMERO, SIMONA, CECCARELLI, SIMONA, CLERICO, Anna, DOMINICI, Carlo, Losty, Paul D, Mannarino, Olga, Mcdowell, Heather P, MEGIORNI, Francesca, PAIANO, MILENA, Pizer, Barry, PIZZUTI, Antonio, Shukla, Rajeev   +11 more
core   +1 more source

Detection of ALK fusion transcripts in FFPE lung cancer samples by NanoString technology [PDF]

, 2017
Background: ALK-rearranged lung cancers exhibit specific pathologic and clinical features and are responsive to anti-ALK therapies. Therefore, the detection of ALK-rearrangement is fundamental for personalized lung cancer therapy. Recently, new molecular
A Cesano, Adriana Cruvinel Carloni, Adriane F. Evangelista, AP Becker, AS Crystal, AT Shaw, Cristovam Scapulatempo-Neto, DR Camidge, DW-S Wong, EL Kwak, EM Gaughan, FH Wilson, Flávia E. de Paula, I Dagogo-Jack, Iberê Cauduro Soares, J Wu, JM Heuckmann, Jose Elias Miziara, JS Reis-Filho, K McKeage, K Rikova, K Takeuchi, LS Yamane, M Soda, Maicon F. Zanon, Maressa Ferreira-Neto, Mariana Andozia Morini, ME Lira, MM Kulkarni, MW Wynes, Pedro de Marchi, R Roskoski, Rui M. Reis, S-H Jung, SM Ali, SW Morris, T-M Rogers, YP Mossé   +37 more
core   +2 more sources

Anaplastic lymphoma kinase in human cancer [PDF]

Journal of Molecular Endocrinology, 2011
The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)–ALK chimera ...
Barreca A, Lasorsa E, Riera L, Machiorlatti R, Piva R, Ponzoni M, Kwee I, Bertoni F, Piccaluga PP, Pileri SA, Inghirami G, European T-Cell Lymphoma Study Group, Barreca A, Chiarle R, Cuccuru G, Inghirami G, Martinoglio B, Medico E, Pellegrino E, Piva R, Ruberto ML, Voena C, Fornari A, Novero D, Chilosi M, Zamò A, Facchetti F, Lonardi S, De Chiara A, Fulciniti F, Doglioni C, Ponzoni M, Agnelli L, Neri A, Todoerti K, Piccaluga PP, Pileri S, Falini B, Tiacci E, Van Loo P, Tousseyn T, De Wolf-Peeters C, Geissinger E, Konrad Muller-Hermelink H, Rosenwald A, Piris MA, Rodriguez ME   +46 more
openaire   +4 more sources

Anaplastic Lymphoma Kinase Is Required for Neurogenesis in the Developing Central Nervous System of Zebrafish [PDF]

, 2013
10.1371/journal.pone.0063757PLoS ...
A Pasini, A Weiss, B Bajoghli, C Englund, C Loeb-Hennard, CB Kimmel, CE Loren, CE Loren, CH Kim, Christoph Winkler, D Di Paolo, D Liedtke, DA Lyons, E Benz-Lemoine, E Vernersson, EA Musgrove, F Dolbeare, Fernando de Castro, GR Ott, H Grandel, HC Park, HH Lee, HM Pogoda, I Janoueix-Lerosey, J Degoutin, J Schlessinger, JD Roll, JM Maris, K Tomita, L Godinho, L Lo, M Cheng, M Shiota, M Soda, Mangeng Cheng, Mariusz Wasik, ME Robu, MS Cooper, N Bertrand, P Fischer, P Perez-Pinera, Qian Zhang, R Chiarle, R Diez del Corral, R Kageyama, R Kageyama, RE George, RH Palmer, Robert Kelsh, S Zhu, SH Yi, Sheng Yao, SP Hurley, SS Lopes, SW Morris, T Berry, T Iwahara, T Reiff, TT To, U Langheinrich, V Link, V Thermes, WG Dirks, Y Chen, YP Mosse, Z Dong   +65 more
core   +7 more sources

A novel patient-derived tumorgraft model with TRAF1-ALK anaplastic large-cell lymphoma translocation. [PDF]

, 2014
Although anaplastic large-cell lymphomas (ALCL) carrying anaplastic lymphoma kinase (ALK) have a relatively good prognosis, aggressive forms exist. We have identified a novel translocation, causing the fusion of the TRAF1 and ALK genes, in one patient ...
...], Abate, F., Abele, C., Acquaviva, A., Agostinelli, C., Aime, S., Aliberti, S., Barreca, A., Bertoni, F., Bessone, L., Boi, M., Cerchietti, L., Chan, W.C., Cheng, M., Crescenzo, R., Di Giacomo, F., Falini, B., Ficarra, E., Gaudiano, M., Inghirami, G., Iqbal, J., Kwee, I., Landra, I., Lasorsa, E., Longo, D.L., Machiorlatti, R., Messana, K., Novero, D., Pera-Gresely, B., Piccaluga, P.P., Pileri, S., Piva, R., Ponzoni, M., Rabadan, R., Rinaldi, A., Ruggeri, B., Shultz, L.D., Tabb\uf2, F., The European T-cell Lymphoma Study Group [..., Tiacci, E., Todaro, M., Tousseyn, T., Van Der Krogt, J.-A., Wlodarska, I.   +43 more
core   +1 more source

Anaplastic Lymphoma Kinase in Cutaneous Malignancies [PDF]

Cancers, 2017
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that has been implicated in the pathogenesis of a variety of neoplasms. As suggested by its name, ALK was first described as part of a translocation product in cases of anaplastic large-cell lymphoma, with other genetic and cytogenetic ALK mutations subsequently coming to attention in the ...
Cao, Severine, Nambudiri, Vinod
openaire   +3 more sources

Genetic and immunohistochemical analyses of ciliated muconodular papillary tumors of the lung: A report of five cases

SAGE Open Medical Case Reports, 2019
Ciliated muconodular papillary tumors are benign lesions located in the peripheral lung field. Recent studies revealed BRAF and epidermal growth factor receptor gene mutations and anaplastic lymphoma kinase gene rearrangement.
Jumpei Kashima, Tsunekazu Hishima, Akiko Tonooka, Shin-ichiro Horiguchi, Toru Motoi, Yusuke Okuma, Yukio Hosimi, Hirotoshi Horio   +7 more
doaj   +1 more source