Results 81 to 90 of about 42,587 (212)

Doxorubicin has a synergistic cytotoxicity with cucurbitacin B in anaplastic thyroid carcinoma cells

Tumor Biology, 2017
In this study, the combined effect of doxorubicin with cucurbitacin B on survival of anaplastic thyroid carcinoma cells was evaluated. For experiments, 8505C and CAL62 human anaplastic thyroid carcinoma cells were used.
Si Hyoung Kim, Jun Goo Kang, Chul Sik Kim, Sung-Hee Ihm, Moon Gi Choi, Hyung Joon Yoo, Seong Jin Lee   +6 more
doaj   +1 more source

Four‐Year Outcomes for Nivolumab With Chemotherapy and Bevacizumab in Patients With Nonsquamous NSCLC in the TASUKI‐52

Cancer Science, EarlyView.
This follow‐up study for TASUKI‐52 trial demonstrates the 4‐year beneficial efficacy of nivolumab (NIV) combined with chemotherapy (CP) and bevacizumab (BEV) in patients with nonsquamous non‐small cell lung cancer (NSCLC) and reveals potential patient backgrounds associated with long‐term survival.
Jong‐Seok Lee, Shunichi Sugawara, Jin‐Hyoung Kang, Hye Ryun Kim, Naoki Inui, Toyoaki Hida, Ki Hyeong Lee, Tatsuya Yoshida, Hiroshi Tanaka, Cheng‐Ta Yang, Takako Inoue, Makoto Nishio, Yasushi Goto, Tomohide Tamura, Nobuyuki Yamamoto, Chong‐Jen Yu, Hiroaki Akamatsu, Shigeru Takahashi, Kazuhiko Nakagawa   +18 more
wiley   +1 more source

ALK Positive Anaplastic Large Cell Lymphoma Presenting as Extensive Bone Involvement [PDF]

Journal of Clinical and Diagnostic Research, 2015
Anaplastic lymphoma kinase (ALK) positive Anaplastic large cell lymphoma (ALCL) represents approximately 2% of all Non-Hodgkin’s lymphomas that commonly involves nodal as well as a wide variety of extra nodal sites, as skin, soft tissue, bones and lungs,
Smeeta Gajendra, Ritesh Sachdev, Lipika Lipi, Shalini Goel, Ruchira Misra   +4 more
doaj   +1 more source

Symptomatic CNS Radiation Necrosis Requiring Neurosurgical Resection During Treatment with Lorlatinib in ALK-Rearranged NSCLC: A Report of Two Cases. [PDF]

, 2020
Central nervous system (CNS) metastasis carries a significant morbidity and mortality in anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC).
Al-Holou, Wajd, Armas, Octavio, Kubota, Takafumi, Nagasaka, Misako, Ou, Sai-Hong Ignatius, Raval, Kunil, Robinette, Natasha, Zhu, Viola W   +7 more
core   +1 more source

A Case of Metastatic Atypical Neuroendocrine Tumor with ALK Translocation and Diffuse Brain Metastases. [PDF]

, 2017
A challenge in precision medicine requires identification of actionable driver mutations. Critical to such effort is the deployment of sensitive and well-validated assays for mutation detection.
Ali, Siraj, Bergsland, Emily K, Bivona, Trever G, Damato, Bertil, Fogh, Shannon, Miller, Vincent A, Urisman, Anatoly, Wang, Victoria E, Wolfe, John, Young, Lauren   +9 more
core   +1 more source

Peripheral T-cell lymphomas: a review of current approaches and hopes for the future. [PDF]

, 2013
Peripheral T-cell lymphomas (PTCL) are a diverse group of lymphoproliferative disorders, which share a common denominator of overall poor prognosis, with few exceptions.
Burki, Meher, Pro, Barbara, Skarbnik, Alan P   +2 more
core   +3 more sources

New generation anaplastic lymphoma kinase inhibitors

Translational Lung Cancer Research, 2019
Anaplastic lymphoma kinase (ALK) gene translocations are pro-tumoral driver alterations that encompass 3-7% of non-squamous non-small cell lung cancer (NSCLC) with specific, clinic and histologic features. The therapeutic strategy depends on anti-ALK tyrosine kinase inhibitors (TKIs) of which crizotinib was the first approved for clinical use.
Delmonte, Angelo, Burgio, Marco Angelo, Verlicchi, Alberto, Bronte, Giuseppe, Cravero, Paola, Ulivi, Paola, Martinelli, Giovanni, Crinò, Lucio   +7 more
openaire   +4 more sources

Dynamics of the CD9 interactome during bacterial infection of epithelial cells by proximity labelling proteomics

The FEBS Journal, EarlyView.
We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson, Isabel Fernandes Parreira, Ruth H. Thompson, Mark O. Collins, Jonathan G. Shaw, Luke R. Green   +5 more
wiley   +1 more source

Primary bone ALK-positive anaplastic large cell lymphoma presented as a giant extraskeletal mass with coagulation necrosis

Radiology Case Reports
Anaplastic large cell lymphoma (ALCL) represents one of the rare types of non-Hodgkin lymphoma. We describe a case of primary bone anaplastic lymphoma kinase (ALK)-positive ALCL presented as a giant extraskeletal mass with extensive coagulation necrosis.
Shuji Nagata, Miyuki Sawano, Yuki Shouji, Masayuki Oka, Seiji Kurata, Koji Hiraoka, Jun Akiba, Shuichi Tanoue   +7 more
doaj   +1 more source

Response to erlotinib in a patient with lung adenocarcinoma harbouring the EML4-ALK translocation: A case report. [PDF]

, 2015
Lung cancer is the leading cause of cancer-associated mortality worldwide, and the mainstay of treatment remains to be personalised therapy. Tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKIs) have been reported to exert a ...
Alì, G., Boldrini, L., Chella, A., Davini, F., Fontanini, G., Lupi, C., Mussi, A., Niccoli, C., Proietti, A.   +8 more
core   +1 more source