Results 191 to 200 of about 2,157,998 (396)

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

149. Distal Forepaw Muscle Fibrosis and Entheseal Damage in a Repetitive Overuse Injury Model

Plastic and Reconstructive Surgery, Global Open
Parth Raju Patel, BSc, Pharmacology, Alex G. Lambi, MD, Anil Shetty, MD, Istvan P. Tamas, N/A, Steven N. Popoff, PhD, Cell Biology/Anatomy, Mary F. Barbe, PhD, Anatomy   +5 more
doaj   +1 more source

Back to the anatomy lab: a forgotten foundation or an ongoing necessity? [PDF]

BMC Med Educ
Temi̇zsoy Korkmaz F, Çandir Gürses BN, Balci Yapalak AN, Gürses İA.   +3 more
europepmc   +1 more source

Cranial anatomy and taxonomy of the erythrosuchid archosauriform‘Vjushkovia triplicostata’Huene, 1960, from the Early Triassic of European Russia

, 2019
Richard J. Butler, А. Г. Сенников, Emma M. Dunne, Martín D. Ezcurra, Brandon P. Hedrick, Susannah C. R. Maidment, Luke E. Meade, Thomas J. Raven, David J. Gower   +8 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Innovative Approach to Understanding Complex Neuroanatomy Through 'Acting-Out', Immersive 3D Modelling. [PDF]

Clin Teach
Kulow C, Sandrock M.
europepmc   +1 more source

The concept of schizotypy — A computational anatomy perspective

, 2015
Claudia Modenato, Bogdan Draganski
openalex   +1 more source

Anatomy-aware measurement of segmentation accuracy [PDF]

, 2016
H. R. Tizhoosh, A.A. Othman
openalex   +1 more source

The effectiveness of virtual and augmented reality in health sciences and medical anatomy

Anatomical Sciences Education, 2017
Christian Moro, Zane Stromberga, A. Raikos, A. Stirling   +3 more
semanticscholar   +1 more source

The distinction between anatomy and comparative anatomy [PDF]

Science, 1886
openaire   +3 more sources