Results 181 to 190 of about 3,863 (219)

Enantioselective synthesis of (+)-anatoxin-a via enyne metathesis

Tetrahedron, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Jehrod B. Brenneman, Rainer Machauer, Stephen F. Martin   +2 more
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A short and enantioselective synthesis of (+)-Anatoxin-a

Tetrahedron Letters, 1992
Abstract A short and enantioselective total synthesis of the neurotoxic alkaloid (+)-Anatoxin-a ( 1 ) from the L-pyroglutamic acid derivative 2 is described. The key step involves an intramolecular cyclisation of an N-tosyl iminium ion derived from the corresponding α-methoxy sulfonamide.
Peter Somfai, Jens Åhman
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Synthesis of (+)-anatoxin-a using enyne metathesis

Tetrahedron Letters, 2004
Abstract Synthesis of N -tosylanatoxin- a was achieved by metathesis of enyne in cis -substituents on a pyrrolidine derivative. Metathesis reactions of enyne having terminal alkyne using various ruthenium-carbene complexes did not give a good results. However, when the terminal alkyne was protected with a TMS group, the reaction proceeded smoothly
Miwako Mori, Tomohiro Tomita, Yoichi Kita, Tsuyoshi Kitamura   +3 more
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Biosynthesis of anatoxin-a and analogues (anatoxins) in cyanobacteria

Toxicon, 2014
Freshwater cyanobacteria produce secondary metabolites that are toxic to humans and animals, the so-called cyanotoxins. Among them, anatoxin-a and homoanatoxin-a are potent neurotoxins that are agonists of the nicotinic acetylcholine receptor. These alkaloids provoke a rapid death if ingested at low doses. Recently, the cluster of genes responsible for
Annick, Méjean, Guillaume, Paci, Valérie, Gautier, Olivier, Ploux   +3 more
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Potential developmental toxicity of anatoxin‐a, a cyanobacterial toxin

Journal of Applied Toxicology, 2005
AbstractSome 2000 species of cyanobacteria (blue‐green algae) occur globally in aquatic habitats. They are able to survive under a wide range of environmental conditions and some produce potent toxins. Toxin production is correlated with periods of rapid growth (blooms) and 25%–70% of blooms may be toxic.
E H, Rogers, E S, Hunter, V C, Moser, P M, Phillips, J, Herkovits, L, Muñoz, L L, Hall, N, Chernoff   +7 more
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ChemInform Abstract: An Efficient Synthesis of (+)‐Anatoxin‐a.

ChemInform, 1993
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
M. SKRINJAR, C. NILSSON, L.‐G. WISTRAND   +2 more
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Synthetic and stereochemical studies directed towards anatoxin-a

Journal of the Chemical Society, Perkin Transactions 1, 1991
The synthesis and stereocontrolled AgI-catalysed cyclisation of a series of allenic amino esters 8a–e is described. For compounds 8a–d the cis-2,5-disubstituted pyrrolidine 9 is formed exclusively but the primary amine 8e undergoes cyclisation nonselectively to give a mixture of cis- and trans-pyrrolidines 9e and 10e.
Nicholas J. S. Huby, Richard G. Kinsman, David Lathbury, Peter G. Vernon, Timothy Gallagher   +4 more
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Behavioural effects of anatoxin, a potent nicotinic agonist, in rats

Neuropharmacology, 1992
Preliminary behavioural studies with the nicotinic agonist (+)-anatoxin have been carried with procedures sensitive to (-)-nicotine. In experimentally naive rats, (+)-anatoxin decreased locomotor activity; this effect resembled that of (-)-nicotine, but it was not blocked by mecamylamine.
I P, Stolerman, E X, Albuquerque, H S, Garcha   +2 more
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Analysis of anatoxin-a in aqueous samples

Chromatographia, 1997
Anatoxin-a is a naturally occurring, potent neurotoxin produced by some species of blue-green algae. Release of anatoxin-a into water bodies on cell lysis is of concern to farmers, whose livestock may be affected by drinking contaminated water; to recreational users of reservoirs where a blue-green algal scum is present; and to water companies, who ...
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Quantitative Structure-activity Relationships Of (+)-anatoxin-a Derivatives

Natural Product Letters, 1994
Abstract The QSAR of a series of 21 nicotinic agonists, anatoxin-a (AnTX) and derivatives, was investigated using multivariate statistical techniques. Physicochemical properties were calculated for the compounds using computational chemistry. In order to model the structures it was necessary to choose a common conformation.
Gallagher, TC, Manallack, DT, Ellis, DD, Thompson, PE, Livingstone, DJ   +4 more
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