Results 141 to 150 of about 9,354,751 (270)

Antineutrophilic Cytoplasmic Antibody–Positive Vasculitis Associated With Thromboangiitis Obliterans in a Middle-Aged Man

Annals of Internal Medicine: Clinical Cases
Antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitides are autoimmune diseases with multisystem manifestations. We report the case of a 55-year-old Asian man with a history of cigarette smoking who presented with ischemic lesions of the ...
Naushad Abid, Hamzah Naushad Siddiqui
doaj   +1 more source

Neutrophil Extracellular Traps: From Mechanistic Insights to Therapeutic Targeting

MedComm, Volume 7, Issue 11, November 2026.
Neutrophil extracellular traps act as multimodal signal processors in cancer via three mechanisms: biomechanical scaffolds activating integrin–FAK signaling and excluding immune cells; immunometabolic hubs driving glycolysis and immunosuppression; and signal‐integration platforms synergistically activating oncogenic pathways.
Hongjie Fan, Yurui Tong, Bufu Tang, Jihong Hu, Xuefeng Kan, Bin Liang   +5 more
wiley   +1 more source

Kidney transplantation in ANCA-associated vasculitis.

, 2019
The kidney is commonly affected in patients with ANCA-associated vasculitis (AAV), causing end-stage renal disease (ESRD) in 20-40% of cases. Kidney transplantation is the treatment of choice for eligible patients with ESRD due to AAV.
Grigorescu, Melissa, Sagmeister, Michael S, Schönermarck, Ulf   +2 more
core   +1 more source

Similarities and Differences Between Patients Diagnosed with ANCA-Associated Vasculitis Who Are Positive and Negative for ANCA: University Clinic Practice and Expertise

Medicina
Background and objective. Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) affects small- to medium-sized vessels and is characterized by the production of ANCAs. The ANCA-negative term is used if the patient otherwise fulfills the
Giedre Dereseviciene, Jolanta Dadoniene, Dalia Miltiniene   +2 more
doaj   +1 more source

CpG oligodeoxynucleotide stimulates production of anti-neutrophil cytoplasmic antibodies in ANCA associated vasculitis

BMC Immunology, 2008
Background Wegener's Granulomatosis and Microscopic Polyangiitis are life-threatening systemic necrotizing vasculitides of unknown aetiology. The appearance of circulating antibodies to neutrophil cytoplasmic antigens (ANCA) is strongly associated with ...
Sarvestani Ghafar, Patel Mittal, Nitschke Jodie, Jeffs Lisa, Hurtado Plinio R, Cassidy John, Hissaria Pravin, Gillis David, Au Peh Chen   +8 more
doaj   +1 more source

Neutrophils: Heterogeneity, Biology, Diseases, and Therapeutic Strategies

MedComm, Volume 7, Issue 11, November 2026.
Neutrophils exhibit remarkable functional plasticity and play dual roles in tissue protection and disease progression. This review summarizes their key biological functions and highlights the shift from conventional broad‐spectrum interventions to neutrophil‐based drug delivery systems.
Yibing Zhang, Siwen Wu, Yusi Wang, Die Hu, Li Yang   +4 more
wiley   +1 more source

Respiratory manifestations of ANCA‐associated vasculitis

The Clinical Respiratory Journal, 2016
AbstractBackgroundThe prevalence of pulmonary manifestations of ANCA‐associated vasculitis (AAV) is not well understood. This study describes the prevalence of respiratory complications of AAV detected via imaging in patients presenting to a secondary renal centre and describes the associations with mortality.Methods105 patients with AAV were ...
Greenan, Kerry, Vassallo, Diana, Chinnadurai, Rajkumar, Ritchie, James, Shepherd, Kate, Green, Darren, Ponnusamy, Arvind, Sinha, Smeeta   +7 more
openaire   +3 more sources

Evaluation of ANCA in vasculitis and non-vasculitis diseases

Purpose: The present study aims to evaluate the existence of anti-neutrophil cytoplasmic antibody (ANCA) in vasculitis and non-vasculitis diseases.
Kaleli, İ., Özkan, B., Mete, E., Ergin, Ç., Demir, M., Çalışkan, A., Öner, S.Z.   +6 more
core   +1 more source

Combined Pulmonary Fibrosis and Emphysema: Current Status and Future Perspective

The Clinical Respiratory Journal, Volume 20, Issue 11, November 2026.
This review summarizes recent advances in combined pulmonary fibrosis and emphysema (CPFE), proposing a novel etiologic classification framework encompassing four subtypes. We integrate a diagnostic algorithm to guide precise management and highlight emerging artificial intelligence strategies for risk stratification and dynamic prognostic assessment ...
Qinyu Deng, Chen Chen, Qinghe Zhang, Zilin Wei, Jianqi Sun, Feng Li   +5 more
wiley   +1 more source

Pathogenesis of ANCA-associated vasculitis: An update

, 2016
International audienceAntineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) constitutes a group of rare diseases characterized by necrotizing inflammation of small blood vessels and the presence of ANCA.
Jarrot, Pierre-André, Kaplanski, Gilles
core   +2 more sources