Results 61 to 70 of about 2,073 (179)

JCS/JHRS 2020 Guideline on Pharmacotherapy of Cardiac Arrhythmias

, 2022
Journal of Arrhythmia, Volume 38, Issue 6, Page 833-973, December 2022.
Katsushige Ono, Yu‐ki Iwasaki, Masaharu Akao, Takanori Ikeda, Kuniaki Ishii, Yasuya Inden, Kengo Kusano, Yoshinori Kobayashi, Yukihiro Koretsune, Tetsuo Sasano, Naokata Sumitomo, Naohiko Takahashi, Shinichi Niwano, Nobuhisa Hagiwara, Ichiro Hisatome, Tetsushi Furukawa, Haruo Honjo, Toru Maruyama, Yuji Murakawa, Masahiro Yasaka, Eiichi Watanabe, Takeshi Aiba, Mari Amino, Hideki Itoh, Hisashi Ogawa, Yasuo Okumura, Chizuko Aoki‐Kamiya, Jun Kishihara, Eitaro Kodani, Takashi Komatsu, Yusuke Sakamoto, Kazuhiro Satomi, Tsuyoshi Shiga, Tetsuji Shinohara, Atsushi Suzuki, Shinya Suzuki, Yukio Sekiguchi, Satoshi Nagase, Noriyuki Hayami, Masahide Harada, Tadashi Fujino, Takeru Makiyama, Mitsunori Maruyama, Junichiro Miake, Shota Muraji, Hiroshige Murata, Norishige Morita, Hisashi Yokoshiki, Koichiro Yoshioka, Kenji Yodogawa, Hiroshi Inoue, Ken Okumura, Takeshi Kimura, Hiroyuki Tsutsui, Wataru Shimizu, the Japanese Circulation Society and, Japanese Heart Rhythm Society Joint Working Group   +56 more
wiley   +1 more source

Meta-analysis of T peak –T end and T peak –T end /QT ratio for risk stratification in congenital long QT syndrome [PDF]

, 2018
Background and objectives: Congenital long QT syndrome (LQTS) predisposes affected individuals to ventricular tachycardia/fibrillation (VF/VF), potentially resulting in sudden cardiac death.
Baranchuk, Adrian M., Bazoukis, George, Georgopoulos, Stamatis, Gong, Mengqi, Letsas, Konstantinos P., Liu, Tong, Meng, Lei, Tse, Gary, Vassiliou, Vassilios S., Wong, Cheuk Wai, Wong, Martin C.S., Xia, Yunlong, Yan, Gan-Xin   +12 more
core   +1 more source

Safety and efficacy of a 6-month home-based exercise program in patients with facioscapulohumeral muscular dystrophy [PDF]

, 2016
Background: Previous randomized controlled trials investigating exercise training programs in facioscapulohumeral muscular dystrophy (FSHD) patients are scarce and of short duration only.
Antoine, Jean-Christophe, Bachasson, Damien, Bankolé, Landry-Cyrille, Féasson, Léonard, Kadi, Fawzi, Millet, Guillaume, Ponsot, Elodie, Ravelojaona, Marion, Temesi, John, Verges, Samuel, Wuyam, Bernard   +10 more
core   +4 more sources

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Andersen-Tawil Syndrome Presenting with Complete Heart Block

Journal of Neuromuscular Diseases, 2020
Andersen-Tawil syndrome (ATS) is a rare autosomal dominant neuromuscular disorder due to mutations in the KCNJ2 gene. The classical phenotype of ATS consists of a triad of periodic paralysis, cardiac conduction abnormalities and dysmorphic features.
Suetterlin K, Männikkö R, Flossmann E, Sud R, Fialho D, Vivekanandam V, James N, Gossios TD, Hanna MG, Savvatis K, Matthews E   +10 more
openaire   +5 more sources

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Andersen-Tawil Syndrome Presenting with Complete Heart Block [PDF]

, 2021
Andersen-Tawil syndrome (ATS) is a rare autosomal dominant neuromuscular disorder due to mutations in the KCNJ2 gene. The classical phenotype of ATS consists of a triad of periodic paralysis, cardiac conduction abnormalities and dysmorphic features ...
Fialho, D, Flossmann, E, Gossios, TD, Hanna, MG, James, N, Matthews, E, Männikkö, R, Savvatis, K, Sud, R, Suetterlin, K, Vivekanandam, V   +10 more
core  

Population‐Based Study Found Low Risk of Misdiagnosing Long QT Syndrome as Breath‐Holding Spells in Swedish Children

Acta Paediatrica, Volume 115, Issue 5, Page 1116-1125, May 2026.
ABSTRACT Aim An electrocardiogram is commonly recommended in breath‐holding spell management, mainly to rule out long QT syndrome. This retrospective study investigated the risk of long QT syndrome being misdiagnosed as breath‐holding spells in a paediatric population in southern Sweden.
Sanna Hellström Schmidt, Ida Jeremiasen, Erik A. Eklund, Cornelis Jan Pronk   +3 more
wiley   +1 more source

An inwardly rectifying K+ channel is required for patterning. [PDF]

, 2012
Mutations that disrupt function of the human inwardly rectifying potassium channel KIR2.1 are associated with the craniofacial and digital defects of Andersen-Tawil Syndrome, but the contribution of Kir channels to development is undefined.
Bates, Emily, Dahal, Giri Raj, Gassaway, Brandon, Kwok, Benjamin, Ptácek, Louis J, Rawson, Joel, Tong, Ying   +6 more
core  

Opening closed inward rectifier potassium channel doors

British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.
Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger, Fabian Kaiser, Marcel A. G. van der Heyden, Saïd Bendahhou   +3 more
wiley   +1 more source