Results 71 to 80 of about 20,847 (184)

Three‐Dimensional Assessment of Upper Airway Morphology and Sleep‐Disordered Breathing Risk in Unilateral Craniofacial Microsomia: A Pilot Study

Orthodontics &Craniofacial Research, EarlyView.
ABSTRACT Objective Unilateral craniofacial microsomia (UCM) presents varying unilateral deficiencies of the temporomandibular joint, mandibular ramus, masticatory muscles, and adjacent soft tissues and ear. Reduced mandibular and maxillary dimensions may decrease upper airway volume and may increase the risk of sleep‐disordered breathing (SDB).
Akila Aiyar, Peter Stoustrup, Thomas Klit Pedersen, Xiaowen Niu   +3 more
wiley   +1 more source

A Novel KCNJ2 Mutation Identified in an Autistic Proband Affects the Single Channel Properties of Kir2.1

Frontiers in Cellular Neuroscience, 2018
Inwardly rectifying potassium channels (Kir) have been historically associated to several cardiovascular disorders. In particular, loss-of-function mutations in the Kir2.1 channel have been reported in cases affected by Andersen-Tawil syndrome while gain-
Anna Binda, Ilaria Rivolta, Chiara Villa, Elisa Chisci, Massimiliano Beghi, Cesare M. Cornaggia, Roberto Giovannoni, Romina Combi   +7 more
doaj   +1 more source

Access to Safety Net Programs in the U.S. During the COVID‐19 Pandemic: Barriers and Lessons From a Scoping Review

Social Policy &Administration, EarlyView.
ABSTRACT The COVID‐19 pandemic triggered historic expansions of the U.S. social safety net to mitigate unprecedented economic hardship. However, increased government spending and program expansions on paper do not automatically translate into equitable access in practice.
Soohyun Yoon, Jeehae Kang
wiley   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source

Changes in motor unit conduction velocity after unilateral lower‐limb suspension and active recovery are correlated with muscle ion channel gene expression

Experimental Physiology, EarlyView.
Abstract The effects of muscle disuse on the propagation of action potentials along motor unit (MU) muscle fibres, a key process for effective muscle activation and force generation, remain poorly understood. The aim of this study was to investigate changes in action potential propagation and to identify biological factors influencing these changes ...
Giacomo Valli, Fabio Sarto, Francesco Negro, Elena Monti, Giuseppe Sirago, Matteo Paganini, Sandra Zampieri, Martino V. Franchi, Andrea Casolo, Julián Candia, Luigi Ferrucci, Marco V. Narici, Giuseppe De Vito   +12 more
wiley   +1 more source

Can flecainide totally eliminate bidirectional ventricular tachycardia in pediatric patients with Andersen-Tawil syndrome?

Türk Kardiyoloji Derneği Arşivi, 2018
Andersen-Tawil syndrome (ATS) is a disorder that causes episodes of muscle weakness (periodic paralysis), changes in heart rhythm, and developmental abnormalities.
Yakup Ergül, Senem Özgür, Sertaç Hanedan Onan, Volkan Tuzcu   +3 more
doaj   +1 more source

Flecainide for the Treatment of Andersen-Tawil Syndrome

JACC: Clinical Electrophysiology
Andersen-Tawil syndrome type 1 (ATS1) is a rare arrhythmogenic disorder resulting from loss-of-function mutations in KCNJ2. Although the use of flecainide has been proposed to treat and prevent life-threatening arrhythmic events in ATS1, it has only been tested in small case series with limited follow-up.
Tomer D. Mann, Ayhan Yoruk, Raquel A. Neves, Auke T. Bergeman, Martijn J. Bos, Christian van der Werf, Michael H. Gollob, Jason D. Roberts, Habib Khan, Shubhayan Sanatani, Vasanth Vedantham, Byron K. Lee, Anastasiea Yesaulov, Andrew D. Krahn, Rafik Tadros, Arthur A. Wilde, Michael J. Ackerman, Melvin M. Scheinman   +17 more
openaire   +2 more sources

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

Small muscle mass aerobic exercise in health and disease: Unique insights into muscle vascular and metabolic control and performance

Experimental Physiology, EarlyView.
Abstract Studies of small muscle mass exercise (SMME) have revealed that the peripheral O2 transport–utilization cascade is a dynamically regulated system in which perfusive and diffusive components can be selectively amplified, redistributed and mechanically limited depending on contraction pattern, recruitment strategy and intramuscular pressure ...
Shunsaku Koga, David C. Poole, Thomas J. Barstow, Dai Okushima, Richie P. Goulding   +4 more
wiley   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source