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Climate-driven changes in zoonotic risk of arenaviral hemorrhagic fevers in South America. [PDF]

Npj Viruses
Kulkarni PS, Flores-Pérez NY, Jian AH, Bird BH, Johnson CK, Uhart M, Pandit PS.   +6 more
europepmc   +1 more source

Discovery of a primed endothelial progenitor that requires VEGF/ERK inhibition to complete vein differentiation

Ang LT, Zheng SL, Liu KJ, Masaltseva A, Winters J, Jha SK, Yin Q, Qian C, Xiong X, Dailamy A, Xi E, Alcocer JC, Sorensen DW, She R, Smolyar K, Szumska D, Nornes S, Martin RM, Lesch BJ, Restrepo NK, Sun W, Weissman JS, Lickert H, Porteus MH, Skylar-Scott MA, Mosimann C, Sumanas S, De Val S, Red-Horse K, Loh KM.   +29 more
europepmc   +1 more source

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Expression and purification of the surface proteins from Andes virus

Protein Expression and Purification, 2017
Andes virus is the main causative agent of Hantavirus cardiopulmonary syndrome in South America. There are currently no vaccines or treatments against Andes virus. However, there are several evidences suggesting that antibodies against Andes virus envelope glycoproteins may be enough to confer full protection against Hantavirus cardiopulmonary syndrome.
Coralia I Rivas, Frank Camacho, Felipe A Zuniga   +2 more
exaly   +4 more sources

Novel Infection of Pericytes by Andes Virus Enhances Endothelial Cell Permeability.

Virus Research, 2021
Andes Virus (ANDV) non-lytically infects pulmonary microvascular endothelial cells (PMECs) causing a severe capillary leak syndrome termed Hantavirus Pulmonary Syndrome (HPS).
Ramon D. Perez, Elena Gorbonova, E. Mackow   +2 more
semanticscholar   +3 more sources

Effect of Vandetanib on Andes virus survival in the hamster model of Hantavirus pulmonary syndrome

Antiviral Research, 2016
Hantavirus pulmonary syndrome (HPS) is a severe disease caused by hantavirus infection of pulmonary microvascular endothelial cells leading to microvascular leakage, pulmonary edema, pleural effusion and high case fatality. Previously, we demonstrated that Andes virus (ANDV) infection caused up-regulation of vascular endothelial growth factor (VEGF ...
Brian H Bird, Punya Shrivastava-Ranjan, Christina F Spiropoulou   +2 more
exaly   +4 more sources

Andes virus M genome segment is not sufficient to confer the virulence associated with Andes virus in Syrian hamsters

Virology, 2004
Sin Nombre virus (SNV) and Andes virus (ANDV), members of the genus Hantavirus, in the family Bunyaviridae, are causative agents of hantavirus pulmonary syndrome (HPS) in North and South America, respectively. Although ANDV causes a lethal HPS-like disease in hamsters, SNV, and all other HPS-associated hantaviruses that have been tested, cause ...
Jay W Hooper, C S Schmaljohn, Anita K Mcelroy   +2 more
exaly   +3 more sources

Study of Andes virus entry and neutralization using a pseudovirion system

Journal of Virological Methods, 2010
Andes virus (ANDV), a member of the Hantavirus genus in the family Bunyaviridae, causes an acute disease characteristic of New-World hantaviruses called hantavirus pulmonary syndrome (HPS). HPS is a highly pathogenic disease with a case-fatality rate of 40%. ANDV is the only hantavirus reported to spread directly from human-to-human.
Neelanjana Ray, Jay W Hooper
exaly   +3 more sources

Andes-Virus-Induced Cytokine Storm is Partially Suppressed by Ribavirin

Antiviral Therapy, 2013
Background Microbe-induced over-activation of cytokines, especially tumour necrosis factor (TNF)-α, is key to the pathogenesis of hantavirus infection leading to severe inflammation with high mortality rate. Although ribavirin showed promise in inhibiting viral replication in vitro, its clinical efficacy remains
Khaiboullina S., Rizvanov A., Lombardi V., Morzunov S., Reis H., Palotás A., Jeor S.   +6 more
openaire   +4 more sources

Pathogenesis and Host Response in Syrian Hamsters following Intranasal Infection with Andes Virus

PLoS Pathogens, 2011
Hantavirus pulmonary syndrome (HPS), also referred to as hantavirus cardiopulmonary syndrome (HCPS), is a rare but frequently fatal disease caused by New World hantaviruses. In humans HPS is associated with severe pulmonary edema and cardiogenic shock; however, the pathogenesis of this disease remains unclear largely due to a lack of suitable animal ...
David Safronetz, Marko Zivcec, Rebecca Rosenke   +2 more
exaly   +5 more sources

Stability of Andes virus and its inactivation by WHO-recommended hand rub formulations and surface disinfectants.

Journal of Hospital Infection
INTRODUCTION Hantaviruses are responsible for thousands of infections globally. In the absence of vaccines or targeted treatments for severe diseases such as haemorrhagic fever with renal syndrome (HFRS) and hantavirus cardiopulmonary syndrome (HCPS ...
B. Nilsson-Payant, Ranya Fatima Dafi, Selina Krüger, M. Rosenthal, D. Todt, M. Addo, E. Steinmann, T. Meister   +7 more
semanticscholar   +1 more source