Andexanet alfa for the reversal of the low-molecular-weight heparin enoxaparin [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Andexanet alfa (andexanet) is the only approved reversal agent for patients with acute major bleeding during apixaban or rivaroxaban treatment. Its mechanism suggests it may also reverse the effects of low-molecular-weight heparin.
Thijs F. van Haaps +11 more
doaj +4 more sources
Andexanet alfa: trials just leave us with more questions [PDF]
Research and Practice in Thrombosis and HaemostasisAndexanet Alfa in Acute Intracranial Hemorrhage in Patients Receiving an Oral Factor Xa Inhibitor (ANNEXA-I), the first ever randomized controlled trial of a reversal agent for direct oral anticoagulants, was published in 2024.
Richard J. Buka
doaj +5 more sources
Procoagulant off-target effect of the direct oral anticoagulant reversal agent Andexanet alfa [PDF]
Blood Vessels, Thrombosis & Hemostasis: Patients with hemorrhage after treatment with direct oral anticoagulants (DOACs) are saved from hematoma expansion by administration of Andexanet alfa, a modified factor Xa analog.
Ischa M. S. Hoornstra +9 more
doaj +3 more sources
Volume and Location Analysis of Intracerebral Hemorrhage for the Appropriate Use of Andexanet Alfa [PDF]
Neurologia Medico-ChirurgicaAndexanet alfa was approved as a reversal agent for Factor Xa inhibitors in patients with uncontrolled or life-threatening bleeding, such as intracerebral hemorrhage. However, its use in cases of small hemorrhages remains controversial.
Takeru UMEMURA +13 more
doaj +3 more sources
Andexanet alfa for the reversal of anticoagulation: Dutch practice data [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Andexanet alfa is a reversal agent for factor Xa (FXa) inhibitors (rivaroxaban and apixaban) and is available for the treatment of severe FXa inhibitor-associated bleeding.
Jurjen F. Krommenhoek +9 more
doaj +4 more sources
Real-world andexanet alfa utilization and the association between delay in administration due to hospital transfer and all-cause inpatient mortality [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Evaluations of andexanet alfa for the reversal of factor Xa inhibitor-associated bleeding have been small, with cohorts drawn from single/limited sites.
Huiqiao Fan +2 more
doaj +3 more sources
Fatal drug reaction to andexanet alfa: a case report [PDF]
eJHaemAndexanet alfa is a recombinant, modified factor Xa (FXa) molecule that is used for the reversal of the anticoagulant effect of oral anti‐FXa anticoagulants in patients with major haemorrhage.
Richard J. Buka +2 more
doaj +3 more sources
Position statement of the Polish Society of Gastroenterology on the use of andexanet alfa in patients with gastrointestinal bleeding taking factor Xa inhibitors [PDF]
Gastroenterology ReviewIn Poland, there has been a steady increase in the number of patients receiving factor Xa (FXa) inhibitors as part of anticoagulant therapy. Despite their high therapeutic efficacy and the lack of a need for dose monitoring, these agents are responsible ...
Krystian Adrych +4 more
doaj +3 more sources
Combined Antithrombin and Heparin Supplementation to Blood for Restoring Heparin Responsiveness After Andexanet Alfa Exposure: An In Vitro Model [PDF]
eJHaemBackground: Andexanet alfa, a Gla‐domainless mutant factor Xa (GDXa), reverses oral FXa inhibitors but can cause severe heparin resistance during cardiopulmonary bypass (CPB).
Amir L. Butt +6 more
doaj +3 more sources
Management of factor Xa inhibitor–related traumatic non‐intracranial bleeding events with andexanet alfa or four‐factor prothrombin complex concentrate in a US multicenter observational study [PDF]
Journal of the American College of Emergency Physicians OpenObjectives This study describes clinical characteristics and management strategies for patients with factor Xa (FXa) inhibitor–related traumatic non‐intracranial bleeds who were treated with andexanet alfa or four‐factor prothrombin complex concentrate ...
Paul P. Dobesh +6 more
doaj +3 more sources