Results 51 to 60 of about 1,330 (154)
European Journal of Clinical Investigation, Volume 55, Issue 9, September 2025.Effective stroke prevention in AF requires a comprehensive holistic approach incorporating appropriate risk stratification, guideline‐adherent anticoagulation and management of underlying cardiovascular conditions and other comorbidities. The ABC pathway, supported by characterisation using the 4S‐AF framework, provides a structured approach to ...
Amir Askarinejad +4 more
wiley +1 more source
Internal Medicine Journal, Volume 55, Issue 7, Page 1114-1119, July 2025.Abstract Background An increasing number of patients in Australia are taking direct oral anticoagulants for a variety of indications since their introduction in the treatment landscape. There has always been some concern about the optimal management approach in the setting of major and/or life‐threatening bleeding.
Sara Shu‐Ling Ng +4 more
wiley +1 more source
Internal Medicine Journal, Volume 55, Issue 7, Page 1174-1183, July 2025.Abstract Direct oral anticoagulants (DOACs) are widely prescribed to prevent and treat venous and arterial thromboembolism, supported by published evidence, and are preferred over warfarin in many guidelines. Although the risk of major bleeding, in particular intracranial haemorrhage (ICH), is decreased with DOACs, gastrointestinal bleeding is ...
Huyen A. Tran +7 more
wiley +1 more source
Safety, pharmacokinetics, and reversal of apixaban anticoagulation with andexanet alfa
Blood Advances, 2017 : Direct factor Xa (FXa) inhibitors lack a specific reversal agent for emergencies such as major bleeding or urgent surgery. Andexanet alfa, a modified, catalytically inactive, recombinant human FXa derivative, reverses anticoagulant effect by binding ...
Deborah Siegal +13 more
doaj +1 more source
Association of Anaesthetists guidelines: the use of blood components and their alternatives
Anaesthesia, Volume 80, Issue 4, Page 425-447, April 2025.Summary Background The administration of blood components and their alternatives can be lifesaving. Anaemia, bleeding and transfusion are all associated with poor peri‐operative outcomes. Considerable changes in the approaches to optimal use of blood components and their alternatives, driven by the findings of large randomised controlled trials and ...
Akshay Shah +12 more
wiley +1 more source
POSSIBILITIES OF INHIBITING ANTICOAGULANT ACTIVITIES THAT INHIBIT XA-FACTOR
Атеротромбоз, 2019 The article deals with the possibility of suppressing the effect of drugs inhibiting the activity of the Xa-Factor of the clotting blood system. Wide indications for oral anticoagulants are atrial fibrillation, venous thrombosis, thromboembolism, etc ...
A. D. Erlich
doaj +1 more source
Simultaneous Treatment of Two Severe Acute Intoxication and Acute Kidney Injury
Seminars in Dialysis, Volume 38, Issue 2, Page 152-155, March/April 2025.ABSTRACT Extracorporeal therapies could be required for treatment of life‐threatening severe acute intoxication. We present the case of an 82‐year‐old patient admitted to our Nephrology Unit because of metformin‐associated lactic acidosis (MALA) and acute kidney injury (AKI stage III AKIN criteria).
Fulvia Zappulo +7 more
wiley +1 more source
Difficult Intraoperative Heparinization Following Andexanet Alfa Administration
Clinical Practice and Cases in Emergency Medicine, 2019 Direct oral anticoagulants are now commonplace, and reversal agents are recently becoming available. Andexanet alfa (AnXa), approved by the United States Food and Drug Administration in 2018, is a novel decoy molecule that reverses factor Xa inhibitors ...
C. James Watson +3 more
doaj +1 more source
Correction to: Andexanet Alfa: First Global Approval [PDF]
Drugs, 2018 The article Andexanet Alfa: First Global Approval, written by Young-A Heo, was originally published Online First without open access.
openaire +2 more sources
Transfusion, Volume 65, Issue 9, Page 1728-1737, September 2025.
Elizabeth P. Crowe +21 more
wiley +1 more source