Results 101 to 110 of about 28,940 (212)

Novel compound variants of the AR and MAP3K1 genes are related to the clinical heterogeneity of androgen insensitivity syndrome

Bioscience Reports, 2020
Androgen insensitivity syndrome (AIS; OMIM 300068) is the most frequent cause of 46, XY disorders of sex development (DSD). However, the correlation between genotype and phenotype has not been determined.
Yiping Cheng, Yan Sun, Y. Ji, Dongqing Jiang, Guoxin Teng, Xiaoming Zhou, Xinli Zhou, Guimei Li, Chao Xu   +8 more
semanticscholar   +1 more source

Biocompatible Chemistry: A Plug‐and‐Play Toolbox for Chemical Biology Research

ChemBioChem, Volume 26, Issue 23, November 27, 2025.
The “plug‐and‐play” nature of biocompatible chemistry makes it a powerful toolbox for investigating complicated biological systems and producing drug leads for clinical usages. This review summarizes the commonly used biocompatible reactions and the recent advances of their representative applications in chemical biology research, thus highlighting the
Adam R. Lovato, Zeng Lin, Qingfei Zheng
wiley   +1 more source

Structural analysis of the impact of a novel androgen receptor gene mutation in two adult patients with mild androgen insensitivity syndrome

Andrologia, 2020
Androgen receptor gene (AR) mutations are responsible for androgen insensitivity syndrome (AIS) presenting with a clinical phenotype that ranges from gynaecomastia and/ or infertility in mild AIS (MAIS) to complete testicular feminisation in complete AIS.
M. Hage, D. Drui, B. Francou, S. Mercier, A. Guiochon‐Mantel, J. Belaisch‐ALLART, Y. Péréon, L. Cazabat, P. de Mazancourt, M. Raffin-Sanson   +9 more
semanticscholar   +1 more source

Disorders of sex development (DSD): an overview of recent scientific advances [PDF]

, 2014
Developments in biotechnology have radically altered clinical and research themes in the small field of disorders of sex development, as in other rare medical conditions. In the age of genetics, an increasing number of DSDs have been identified. Aided by
Conway, GS
core  

Variable loss of functional activities of androgen receptor mutants in patients with androgen insensitivity syndrome [PDF]

, 2013
Androgen receptor (AR) mutations in androgen insensitivity syndrome (AIS) are associated with a variety of clinical phenotypes. The aim of the present study was to compare the molecular properties and potential pathogenic nature of 8 novel and 3 ...
Akker, E.L.T. (Erica) van den, Bisschop, P.H. (Peter), Bosch, R. (Rolien), Brinkmann, A.O. (Albert), Brüggenwirth, H.T. (Hennie), Bunch, T. (Trevor), Bunck, M.C.M., Cools, M.B.C.M. (Martine), Drop, S.L.S. (Stenvert), Elfferich, P.C., Faradz, S.M.H. (Sultana), Houtsmuller, A.B. (Adriaan), Hughes, I.A. (Ieuan), Lusher, S.J. (Scott), Oostdijk, W. (Wilma), Royen, M.E. (Martin), Trapman, J. (Jan), Wijngaart, D.J. (Dennis) van de   +17 more
core   +2 more sources

Extracellular Vesicles Released From Prostate Cancer Cells Confer Pro‐Tumor Properties to Adipocytes by Stimulating Lipolysis

BioFactors, Volume 51, Issue 6, November/December 2025.
Extracellular vesicles (EVs) from prostate cancer (PCa) cells induce the release of fatty acids (FFAs) from adipocytes, which in turn sustain tumor cell proliferation and migration via Akt activation. ABSTRACT There is consistent evidence of an association between obesity and the risk of prostate cancer (PCa). A crosstalk between PCa and adipocytes has
Gaia Giannitti, Kinga Kamińska, Sara Marchesi, Riccardo Garavaglia, Ivan Preosto, Małgorzata Grzesiak, Fabrizio Fontana   +6 more
wiley   +1 more source

Complete androgen insensitivity syndrome: Dilemmas for further management after gonadectomy

Journal of Human Reproductive Sciences, 2019
Complete androgen insensitivity syndrome is a rare condition, wherein a genetic male is phenotypically female and is raised as a female. Treatement requires timely gonadectomy, need for long term hormonal replaceent therapy, psycological and genetic ...
Pratibha Singh, Meenakshi Gothwal, Garima Yadav, Kuldeep Singh   +3 more
doaj   +1 more source

Renal Subcapsular xenografing of human fetal external genital tissue - A new model for investigating urethral development. [PDF]

, 2017
In this paper, we introduce our novel renal subcapsular xenograft model for the study of human penile urethral and clitoral development. We grafted fifteen intact fetal penes and clitorides 8-11 weeks fetal age under the renal capsules of gonadectomized ...
Baskin, Laurence, Cao, Mei, Cunha, Gerald, Isaacson, Dylan, Shen, Joel, Sinclair, Adriane, Yue, Xuan   +6 more
core   +2 more sources

Elucidating the Anticancer Mechanisms of Tetrahydroxycurcumin: A Comprehensive Review of Preclinical Studies

Food Science &Nutrition, Volume 13, Issue 11, November 2025.
Tetrahydroxycurcumin is an attractive multifunctional compound in cancer‐driven therapeutics. Its anticancer potential in modulating a wide range of oncogenic signaling networks, combined with its dual properties as an antioxidant and anti‐inflammatory agent, highlights its potential to become a transformative anticancer drug.
Muhammad Shahbaz, Ushna Momal, Hagar M. Mohamed, Asfa Perween, Hammad Naeem, Muhammad Imran, Muzzamal Hussain, Gamal A. Mohamed, Sabrin R. M. Ibrahim, Tadesse Fenta Yehuala, Suliman A. Alsagaby, Waleed Al Abdulmonem, Mohamed A. Abdelgawad, Ehab M. Mostafa, Samy Selim   +14 more
wiley   +1 more source

GENDER ASSIGNMENT IN COMPLETE ANDROGEN INSENSITIVITY SYNDROME. WHO SHOULD BE THE DECISION MAKER

Pakistan Armed Forces Medical Journal, 2020
Androgen insensitivity syndrome (AIS) is a condition in which the target cells are unable to respond to androgenic hormones. This inability can be complete or partial.
Naveed Ahmed, Iftikhar Ahmed, Safdar Awan, Omair Arshad Dar, Shehla Kanwal, C. Aqeel Safdar, Mudasir Saleem   +6 more
doaj   +2 more sources