Results 111 to 120 of about 28,940 (212)

Androgen Receptor Gene Variants in New Cases of Equine Androgen Insensitivity Syndrome

Genes, 2020
In the domestic horse; failure of normal masculinization and virilization due to deficiency of androgenic action leads to a specific disorder of sexual development known as equine androgen insensitivity syndrome (AIS).
D. Villagomez, Eastman G Welsford, W. King, T. Révay   +3 more
semanticscholar   +1 more source

Elevating and empowering reproductive futures: Pediatric and adolescent gynecology's specialized care across the globe

International Journal of Gynecology &Obstetrics, Volume 171, Issue 2, Page 528-537, November 2025.
Abstract Pediatric and adolescent gynecology (PAG) is an expanding subspecialty of obstetrics and gynecology that addresses the reproductive health needs of girls and young women worldwide. In regions with limited subspecialist healthcare providers, general obstetricians, gynecologists, and nurse‐midwives, frontline healthcare providers provide ...
Nichole A. Tyson, Méabh Ní Bhuinneáin, Hema Divakar, Lauren Mauger, Judith Simms Cendan, Marisa Labovsky, FIGO Committee on Adolescent and Youth Health   +6 more
wiley   +1 more source

Androgenetic alopecia: a review [PDF]

, 2017
Purpose Androgenetic alopecia, commonly known as male pattern baldness, is the most common type of progressive hair loss disorder in men. The aim of this paper is to review recent advances in understanding the pathophysiology and molecular mechanism
Caro, Gemma, Fortuna, MARIA CATERINA, Lenzi, Andrea, Lolli, Francesca, Lombardo, Francesco, Pallotti, Francesco, Rossi, Alfredo, Sansone, Andrea   +7 more
core   +1 more source

Different Clinical Presentations and Management in Complete Androgen Insensitivity Syndrome (CAIS)

International Journal of Environmental Research and Public Health, 2019
Complete androgen insensitivity syndrome (CAIS) is an X-linked recessive genetic disorder resulting from maternally inherited or de novo mutations involving the androgen receptor gene, situated in the Xq11-q12 region.
L. Lanciotti, M. Cofini, A. Leonardi, M. Bertozzi, L. Penta, S. Esposito   +5 more
semanticscholar   +1 more source

Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions

MedComm, Volume 6, Issue 11, November 2025.
Ligand–receptor binding activates PLC, which hydrolyzes the membrane lipid PIP2, generating the second messenger's IP3 and DAG. IP3 binding to ER receptors causes Ca2⁺ release. Subsequently, PKC are recruited to the membrane, which induces a conformational change in PKC, leading to the full enzymatic activation.
Yongqi Li, Yuhan Jiang, Zhengxi Hu, Shenglan Yang, Longyin Li, Chaohu Xiong, Ya Gao, Weiguang Sun, Yonghui Zhang   +8 more
wiley   +1 more source

Surface Rendering of External Genitalia of a Fetus at the 32nd Week of Gestation Affected by Partial Androgen Insensitivity Syndrome

Case Reports in Obstetrics and Gynecology, 2013
Objectives. To demonstrate the feasibility of the prenatal diagnosis of partial androgen insensitivity syndrome by 3D-4D ultrasound. Methods. To report prenatal diagnosis of partial androgen insensitivity syndrome at 32nd week of gestation by 3D-4D ...
Vincenzo Mazza, Emma Bertucci, Silvia Latella, Carlotta Cani, Pierluca Ceccarelli, Lorenzo Iughetti, Fulvia Baldinotti, Antonio Percesepe   +7 more
doaj   +1 more source

Complete androgen insensitivity syndrome

Definitions, 2020
Presentation of the case. Phenotypically female patient, 18 years old, 46 XY karyotype, who was evaluated in a tertiary care center for pediatric medicine due to primary amenorrhea.
Rafael Alexis Contreras Cruz, Luis Ernesto Cortez Salvador, Luis Villalta Morales, Eduardo José Fuentes   +3 more
semanticscholar   +1 more source

Epigenetic Clock Analysis of Sex Chromosome Aneuploidies

Aging Cell, Volume 24, Issue 11, November 2025.
Next‐generation epigenetic clocks indicate lower age acceleration and slower pace of aging in 47,XXY than 46,XX, 46,XY, and 47,XYY. A first‐generation clock (Skin & Blood) indicates higher age acceleration in 47,XXY and 47,XYY than 46,XY, while higher naïve CD8+ T in 47,XXY than both 46,XY and 46,XX suggests reduced immunosenescence.
Joshua Zhang, Jordan Teoli, Benjamin Rey, Cristina Vieira, Jean‐François Lemaitre, Ingrid Plotton, Gabriel A. B. Marais, Steve Horvath   +7 more
wiley   +1 more source

"Mixed germ cell testicular tumor" in an adult female

Journal of Human Reproductive Sciences, 2012
The androgen insensitivity (testicular feminization) syndrome was described by Morris in phenotypic females with 46XY karyotype, presenting with primary amenorrhea, adequate breast development, and absent or scanty pubic or axillary hair.
Udasimath Shivakumarswamy, R Purushotham, H K Kumar Naik, K R Nagesha   +3 more
doaj   +1 more source

Modulation of lactose synthesis and orexinergic‐glucose pathway by sex steroid hormones

Physiological Reports, Volume 13, Issue 22, November 2025.
Abstract Sex steroid hormones play a regulatory role in various metabolic processes, including glucose homeostasis via the orexinergic system and lactose synthesis. This review consolidates experimental findings on the mechanisms by which these hormones regulate these two pathways. A systematic search of PubMed, Scopus, and Web of Science identified 15
Jean Claude Hakizimana, Abdullateef Isiaka Alagbonsi   +1 more
wiley   +1 more source