Results 111 to 120 of about 333,981 (315)
Testosterone Influence on Gene Expression in Lacrimal Glands of Mouse Models of Sjögren Syndrome [PDF]
, 2019 Purpose: Sjögren syndrome is an autoimmune disorder that occurs almost exclusively in women and is associated with extensive inflammation in lacrimal tissue, an immune-mediated destruction and/or dysfunction of glandular epithelial cells, and a ...
Kam, Wendy R. +6 more
core +2 more sources
Advanced Science, EarlyView.A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo +13 more
wiley +1 more source
Prospective evaluation of low-dose ketoconazole plus hydrocortisone in docetaxel pre-treated castration-resistant prostate cancer patients. [PDF]
, 2015 BackgroundKetoconazole is a well-known CYP17-targeted systemic treatment for castration-resistant prostate cancer (CRPC). However, most of the published data has been in the pre-chemotherapy setting; its efficacy in the post-chemotherapy setting has not ...
Beckett, LA +6 more
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No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene [PDF]
, 2013 The length ratio of the second to the fourth digit (2D:4D) is a putative marker of prenatal testosterone (T) effects. The number of CAG repeats (CAGn) in the AR gene is negatively correlated with T sensitivity in vitro. Results regarding the relationship
Honekopp, Johannes
core +2 more sources
AGING MEDICINE, EarlyView.The AWGS 2025 consensus shifts focus from diagnosing sarcopenia to promoting muscle health across the lifespan. It simplifies diagnosis to low muscle mass plus low strength, expands screening to middle‐aged adults, and integrates muscle health into the WHO ICOPE framework for early intervention and healthy aging.
Bi Jianghan, Li Jiaojiao, Kang Lin
wiley +1 more source
Sex hormone-binding globulin regulation of androgen bioactivity in vivo : validation of the free hormone hypothesis [PDF]
, 2016 Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens and estrogens. According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiting their diffusion into target tissues.
Antonio, Leen +15 more
core +2 more sources
Androgen receptor dysfunction in human androgen insensitivity
Trends in Endocrinology & Metabolism, 1995 The androgen insensitivity syndromes comprise a spectrum of phenotypic abnormalities in male sex differentiation and development that result from target tissue resistance to androgen action due to molecular lesions in the X-chromosome-linked androgen receptor gene.
openaire +2 more sources
A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis
Animal Models and Experimental Medicine, EarlyView.A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu +6 more
wiley +1 more source
The Pan African Medical Journal, 2016 Testicular feminization, or the androgen insensitivity syndrome, is a rare disease. Because of various abnormalities of the X chromosome, a male, genetically XY, has some physical characteristics of a woman or a full female phenotype. Indeed the androgen
Regragui Souhail +6 more
doaj +1 more source
A preliminary investigation into the effects of a sex-reversal androgen, methyltestosterone, on food utilization and growth of Sarotherodon niloticus (L) fry [PDF]
, 1986 Three groups of Sarotherodon niloticus fry were fed for 8 weeks on diets either treated with 17- & methyltestosterone (MT), alcohol (CA), or untreated (CO). Growth rate and food utilization in the different groups were compared. Results indicate that the
Madu, C.T., Ufodike, E.B.C.
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