Results 91 to 100 of about 333,981 (315)

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source

Tadalafil modulates aromatase activity and androgen receptor expression in a human osteoblastic cell in vitro model [PDF]

, 2016
Purpose Phosphodiesterase type-5 inhibitor (PDE5i) tadalafil administration in men with erectile dysfunction is associated with increased testosterone/estradiol ratio, leading to hypothesize a potential increased effect of androgen action on target ...
Aversa, Antonio, Bimonte, V. M., Fittipaldi, Simona, Francomano, Davide, Greco, E. A., Lenzi, Andrea, Migliaccio, S., Papa, V., Wannenes, F.   +8 more
core   +1 more source

Androgen Receptor and Mechanism of Androgen Action

Annals of Medicine, 1993
Androgen receptor is the intracellular protein that mediates biological actions of physiological androgens (testosterone and 5 alpha-dihydrotestosterone). Androgen receptor belongs to a large family of ligand-dependent proteins whose function is to modulate expression of genes and gene networks in a cell- and tissue-specific manner.
O A, Jänne, J J, Palvimo, P, Kallio, M, Mehto   +3 more
openaire   +2 more sources

Sex‐Specific Regulation of Glycemic Homeostasis by Theabrownin from Pu‐erh Tea

Advanced Science, EarlyView.
Pu‐erh tea's key component, theabrownin (TB), lowers blood glucose in a sex‐specific manner. In females, estrogen boosts intestinal MUC2 production, which dramatically enhances TB's ability to inhibit the carbohydrate‐digesting enzyme α‐glucosidase.
Yang Li, Junliang Kuang, Dan Zheng, Jieyi Wang, Kun Ge, Chun Qu, Xiaojiao Zheng, Zhenxing Ren, Fengjie Huang, Mingliang Zhao, Yimin Sun, Huiheng Zhang, Keke Ding, Xixi Xia, Yajun Tang, Lu Liu, Jian Zhou, Fei Gao, Xiaohui Ma, Yongquan Xu, Guoxiang Xie, Aihua Zhao, Wei Jia   +22 more
wiley   +1 more source

A concise review of testosterone and bone health

Clinical Interventions in Aging, 2016
Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman, Kok-Yong Chin Department of Pharmacology, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lampur, Malaysia Abstract: Osteoporosis is a condition causing significant morbidity and mortality in the elderly
Mohamad NV, Soelaiman IN, Chin KY
doaj  

Nuclear expression of PG-21, SRC-1, and pCREB in regions of the lumbosacral spinal cord involved in pelvic innervation in young adult and aged rats [PDF]

, 2012
In rats, ageing results in dysfunctional patterns of micturition and diminished sexual reflexes that may reflect degenerative changes within spinal circuitry.
Amandusson, Anderson, Balazs, Berkley, Blanchet, Blanco, Blok, Breedlove, Breedlove, Burke, Chambers, Chambers, Collins, Dail, Davidson, De Cesare, Dering, Dering, Eika, Ernfors, Fargo, Ferrini, Finkbeiner, Frankel, Fraser, Ghanadian, Giuliano, Goldstein, Goldstein, Gonzalez, Gray, Gréco, Hancock, Hodges, Holmes, Hsu, Johnson, Jordan, Jordan, Jordan, Kepper, Kurz, Labombarda, Leo, Leslie, Lubischer, Marson, Marson, Marson, Marson, Marson, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Mattson, Mayr, McKenna, McKenna, McManus, Meisel, Monks, Monks, Montminy, Nadelhaft, Nadelhaft, Nadelhaft, Nicolopoulos-Stournaras, Nordeen, O'Bryant, Osborne, Papka, Papka, Papka, Papka, Papka, Purinton, Ranson, Ranson, Ranson, Ranson, Ranson, Ranson, Reichardt, Santer, Schrøder, Sengelaub, Shibata, Smith, Smith, Tan, Tang, Tobin, Ulfhake, VanderHorst, Vera, Watkins, Watson, Williams, Wu, Wu, Yaici, Yamamoto, Yan, Yang, Yang, Yaïci   +108 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

IGFBP5 Restores Endometrial Receptivity and Rescues Implantation Failure in Polycystic Ovary Syndrome

Advanced Science, EarlyView.
Impaired endometrial receptivity contributes to the poor pregnancy outcomes in women with PCOS. The authors found that decreased endometrial IL‐22 levels and disrupted STAT3‐IGFBP5 signaling pathway contributed to impaired endometrial receptivity. Supplementation with IL‐22 or IGFBP5 exerts a protective effect on implantation failure in PCOS‐like mice,
Baoying Liao, Chuyu Yun, Hongying Shan, Yuqian Wang, Xiunan Chen, Weisi Lian, Tianliu Peng, Min Zhao, Xunsi Qin, Kailun Hu, Ping Zhou, Yue Wang, Yanli Pang, Rong Li   +13 more
wiley   +1 more source

Role for growth regulation by estrogen in breast cancer 1 (GREB1) in hormone-dependent cancers [PDF]

, 2018
Sex hormones play important roles in the onset and progression of several cancers, such as breast, ovarian, and prostate cancer. Although drugs targeting sex hormone function are useful in treating cancer, tumors often develop resistance.
Cheng, Meng, Kommagani, Ramakrishna, Michalski, Stephanie   +2 more
core   +2 more sources