Cancer Research, 2009 Suppression of androgen production and function provides palliation but not cure in men with prostate cancer (PCa). Therapeutic failure and progression to hormone refractory prostate cancer (HRPC) are often accompanied by molecular alterations involving ...
R. Hu +11 more
semanticscholar +1 more source
Evidence of the indirect hormonal activity of prohormones using liver S9 metabolic bioactivation and an androgen bioassay [PDF]
, 2008 Prohormones such as dehydroepiandrosterone (DHEA) are steroid precursors that do not show hormonal activity by themselves. Abuse of these prohormones in cattle fattening is hard to prove because of strong in vivo metabolism and the difficulty to detect ...
Bovee, T.F.H. +4 more
core +2 more sources
Sex bias in CNS autoimmune disease mediated by androgen control of autoimmune regulator
Nature Communications, 2016 Male gender is protective against multiple sclerosis and other T-cell-mediated autoimmune diseases. This protection may be due, in part, to higher androgen levels in males. Androgen binds to the androgen receptor (AR) to regulate gene expression, but how
Menglei Zhu +8 more
semanticscholar +1 more source
Correlation between the presence of the nuclear AR-V7 androgen receptor and clinical evolution of prostate cancer: in vitro analysis of a combination of compounds targeting PI3K [PDF]
, 2019 Introduzione: PCa è una malattia multiforme e biologicamente molto eterogenea. Diversi meccanismi chiave nella progressione della malattia da androgeno-dipendente ad androgeno-indipendente (CRCP) possono essere attribuiti ad alterazione nella via di ...
Cattarino, Susanna
core
Impaired Nuclear Export of Polyglutamine-Expanded Androgen Receptor in Spinal and Bulbar Muscular Atrophy. [PDF]
, 2019 Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Prior studies have highlighted the importance of AR nuclear localization in SBMA pathogenesis; therefore, in ...
Arnold, Frederick J. +2 more
core +3 more sources
The Acute Responses of Different-sized Coronary Arteries to Testosterone [PDF]
, 2012 Coronary arteries supply blood to the myocardium. The blood flow within the coronary arteries is altered by various compounds produced within the body. Sex hormones such as testosterone are known to cause the relaxation of large coronary arteries.
Madanu, Sampath
core +2 more sources
Individual 17-Hydroxyprogesterone Responses to hCG Are Not Correlated With Follicle Size in Polycystic Ovary Syndrome. [PDF]
, 2019 Context:In women with polycystic ovary syndrome (PCOS), 17-hydroxyprogesterone (17-OHP) responses to gonadotropin stimulation vary from increased to indistinguishable compared with normal controls.
Chang, R Jeffrey +5 more
core +1 more source
Androgen Signaling in Prostate Cancer.
Cold Spring Harbor Perspectives in Medicine, 2017 Charles Dai, H. Heemers, N. Sharifi
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2017 A. Caldwell +8 more
semanticscholar +1 more source
Diabetes and cardiovascular disease during androgen deprivation therapy for prostate cancer.
Journal of Clinical Oncology, 2006 N. Keating, A. O’Malley, M. Smith
semanticscholar +1 more source