Results 51 to 60 of about 333,981 (315)

Effect of spironolactone and potassium canrenoate on cytosolic and nuclear androgen and estrogen receptors of rat liver [PDF]

, 1987
Spironolactone and potassium canrenoate are diuretics that are used widely for management of cirrhotic ascites. The administration of spironolactone frequently leads to feminization, which has been noted less frequently with the use of potassium ...
Alfredo Di Leo, Antonio Francavilla, Armanini, Aten, Bannister, Bellati, Boisselle, Bradford, Burton, Chopra, Clark, Duffy, Dupont, Eagon, Eagon, Eagon, Eagon, Farrell, Francavilla, Francavilla, Francavilla, Francesco Guglielmi, Fromatin, Giuseppe Fanizza, Greenblatt, Gustafsson, Gustafsson, Huffman, Kneifel, Lorenzo Polimeno, Loriaux, Marco, Menard, Michele Barone, Niewoehner, Norstedt, Patricia K. Eagon, Porter, Porter, Powell-Jones, Rifka, Rogerson, Scatchard, Serafini, Thomas E. Starzl, Turocy, Van Thiel   +46 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Genomic Deletion at 10q23 in Prostate Cancer: More Than PTEN Loss?

Frontiers in Oncology, 2018
The PTEN gene encodes for the phosphatase and tensin homolog; it is a tumor suppressor gene that is among the most frequently inactivated genes throughout the human cancer spectrum. The most recent sequencing approaches have allowed the identification of
Raghavendra Tejo Karthik Poluri, Étienne Audet-Walsh, Étienne Audet-Walsh   +2 more
doaj   +1 more source

Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pAR ser81 and CDK1 signaling: biological implications for men treated with testosterone replacement therapy [PDF]

, 2017
Despite the growing body of knowledge showing that testosterone (T) may not significantly affect tumor progression in hypogonadal patients treated for prostate cancer (Pca), the use of this hormone in this population still remains controversial.
Al-Azzawi, Balk, Baniahmad, Buchanan, Christiansen, Christiansen, Denmeade, Dlewati, Festuccia, Festuccia, Festuccia, Gailly, Hayes, Hellstrom, Huang, Isaacs, Isaacs, Isaacs, Isaacs, Jannini, Key, Liu, Maggi, Morgentaler, Morgentaler, Mostaghel, Neidle, Pagano, Pagano, Page, Page, Pandolfi, Park, Paschal, Pestell, Pitha, Roussel, Schneider, Sonnenschein, Soto, Strauss, Swerdloff, Traish, Vogelzang, Wilson, Yen, Zi   +46 more
core   +1 more source

Membrane androgen receptors may mediate androgen reinforcement [PDF]

Psychoneuroendocrinology, 2010
Anabolic-androgenic steroid (AAS) abuse is widespread. Moreover, AAS are reinforcing, as shown by self-administration in rodents. However, the receptors that transduce the reinforcing effects of AAS are unclear. AAS may bind to classical nuclear androgen receptors (ARs) or membrane receptors. We used two approaches to examine the role of nuclear ARs in
Satoru M, Sato, Jamie A, Johansen, Cynthia L, Jordan, Ruth I, Wood   +3 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Sex Hormones Regulate Innate Immune Cells and Promote Sex Differences in Respiratory Virus Infection

Frontiers in Immunology, 2018
Sex differences in the incidence and severity of respiratory virus infection are widely documented in humans and murine models and correlate with sex biases in numbers and/or functional responses of innate immune cells in homeostasis and lung infection ...
Sapana Kadel, Sapana Kadel, Susan Kovats, Susan Kovats   +3 more
doaj   +1 more source

Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy [PDF]

Cells, 2019
Androgens are not only essential for bone development but for the maintenance of bone mass. Therefore, conditions with androgen deficiency, such as male hypogonadism, androgen-insensitive syndromes, and prostate cancer with androgen deprivation therapy are strongly associated with bone loss and increased fracture risk.
Jia-Feng Chen, Pei-Wen Lin, Yi-Ru Tsai, Yi-Chien Yang, Hong-Yo Kang   +4 more
openaire   +3 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Perspective: A Neuro-Hormonal Systems Approach to Understanding the Complexity of Cryptorchidism Susceptibility

Frontiers in Endocrinology, 2018
Nonsyndromic cryptorchidism is a common multifactorial, condition with long-term risks of subfertility and testicular cancer. Revealing the causes of cryptorchidism will likely improve prediction and prevention of adverse outcomes.
Julia S. Barthold, Richard Ivell
doaj   +1 more source