Results 41 to 50 of about 333,981 (315)

Factors that influence the androgen receptor cistrome in benign and malignant prostate cells

Molecular Oncology, 2019
The androgen receptor (AR) plays key roles in the development of prostate tissue and the development and progression of prostate cancer (PC). AR guides cytodifferentiation and homeostasis in benign luminal epithelial cells; however, in PC, AR instead ...
Ben T. Copeland, Juan Du, Sumanta K. Pal, Jeremy O. Jones   +3 more
doaj   +1 more source

Contextual modulation of social and endocrine correlates of fitness: insights from the life history of a sex changing fish

Frontiers in Neuroscience, 2015
Steroid hormones are critical regulators of reproductive life history, and the steroid sensitive traits (morphology, behavior, physiology) associated with particular life history stages can have substantial fitness consequences for an organism. Hormones,
Devaleena S Pradhan, Devaleena S Pradhan, Tessa K Solomon-Lane, Matthew Scott Grober, Matthew Scott Grober   +4 more
doaj   +1 more source

Prostate-Associated Gene 4 (PAGE4): Leveraging the Conformational Dynamics of a Dancing Protein Cloud as a Therapeutic Target. [PDF]

, 2018
Prostate cancer (PCa) is a leading cause of mortality and morbidity globally. While genomic alterations have been identified in PCa, in contrast to some other cancers, use of such information to personalize treatment is still in its infancy.
Dorff, Tanya, Jolly, Mohit Kumar, Kulkarni, Prakash, Lau, Clayton, Orban, John, Salgia, Ravi, Weninger, Keith   +6 more
core   +3 more sources

Sex hormone-specific regulation of ferroptosis in vascular cells in atherosclerosis: molecular mechanisms and targeted strategies

Frontiers in Physiology
Atherosclerosis (AS), the leading cause of cardiovascular morbidity and mortality worldwide, exhibits significant sex differences in its incidence and pathological progression, yet the underlying molecular mechanisms remain fully elucidated. Ferroptosis,
Keying Yu, Keying Yu, Keying Yu, Jitong Li, Jitong Li, Tenghui Tian, Tenghui Tian, Rui Shi, Rui Shi, Yue Deng, Yue Deng, Yue Deng, Liping Chang, Liping Chang   +13 more
doaj   +1 more source

Salivary testosterone measurement in women with and without polycystic ovary syndrome [PDF]

, 2017
Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65
Adaway, Joanne, Al-Qaissi, Ahmed, Atkin, Stephen, Atkin, Stephen L., Dargham, Soha, Dargham, Soha R., Keevil, Brian, Kilpatrick, Eric, Kilpatrick, Eric S., Sathyapalan, Thozhukat   +9 more
core   +1 more source

Androgen regulation of the androgen receptor coregulators [PDF]

BMC Cancer, 2008
Abstract Background The critical role of the androgen receptor (AR) in the development of prostate cancer is well recognized. The transcriptional activity of AR is partly regulated by coregulatory proteins. It has been suggested that these coregulators could also be important in the progression of prostate cancer. The
Urbanucci, Alfonso, Waltering, Kati K, Suikki, Hanna E, Helenius, Merja A, Visakorpi, Tapio   +4 more
openaire   +4 more sources

Regional variations and socioeconomic factors influencing sex hormone profiles in adolescent girls in Ghana

Frontiers in Reproductive Health
IntroductionAdolescence is a critical period of hormonal changes that affect growth, development, and behaviour. Estrogen, progesterone, and androgen are sex hormones that play important roles in reproductive development and functions.
Eric Kyei-Baafour, Sawudatu Zakariah-Akoto, Michael Ofori, Lutherodt Bentum-Ennin, Oscar Nii Otto Darko, Godfred Egbi, Benjamin Abuaku, Collins Ahorlu, Dorothy Yeboah-Manu   +8 more
doaj   +1 more source

The unique interplay of mitochondrial oxidative phosphorylation (OXPHOS) and immunity and its potential implication for the sex‐ and age‐related morbidity of severe COVID‐19 patients

MedComm, 2023
Aged male patients are more vulnerable to severe or critical symptoms of COVID‐19, but the underlying mechanism remains elusive. In this study, we analyzed previously published scRNA‐seq data from a large cohort of COVID‐19 patients, castrated and ...
Yinchuan Li, Lei Li, Guanghao Wu, Gangcai Xie, Lirong Yi, Jie Zhu, ShiYu Liang, Ya‐ru Huang, Juan Chen, Shaoyang Ji, Fei Sun, Rui‐tian Liu   +11 more
doaj   +1 more source

Parasite-Mediated Mate Preferences in a Cooperatively Breeding Rodent

Frontiers in Ecology and Evolution, 2022
Females of many species discriminate among males when choosing a mate and this can bear indirect and direct benefits including the avoidance of parasite transmission from infested males.
Heike Lutermann, Kemba B. Butler, Nigel C. Bennett   +2 more
doaj   +1 more source

Androgen-independent events in penile development in humans and animals. [PDF]

, 2020
The common view on penile development is that it is androgen-dependent, based first and foremost on the fact that the genital tubercle forms a penis in males and a clitoris in females.
Baskin, Laurence, Cao, Mei, Cooke, Paul S, Cunha, Gerald R, Glickman, Steve, Liu, Ge, Sinclair, Adriane   +6 more
core   +1 more source