Results 61 to 70 of about 247,609 (252)

Effect of maternal body mass index on the steroid profile in women with gestational diabetes mellitus

Frontiers in Endocrinology, 2022
ObjectiveTo explore the effect of maternal body mass index (BMI) on steroid hormone profiles in women with gestational diabetes mellitus (GDM) and those with normal glucose tolerance (NGT).MethodsWe enrolled 79 women with NGT and 80 women with GDM who ...
Yanni Sun, Yanni Sun, Bo Zhu, Bo Zhu, Xingjun Meng, Xingjun Meng, Binbin Yin, Binbin Yin, Kaiqi Wu, Kaiqi Wu, Yifeng Liu, Yifeng Liu, Dandan Zou, Jianyou Xue, Xiao Sun, Xiao Sun, Dan Zhang, Dan Zhang, Zhixin Ma, Zhixin Ma   +19 more
doaj   +1 more source

Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice [PDF]

, 2009
<b>Background</b>: Testicular microliths are calcifications found within the seminiferous tubules. In humans, testicular microlithiasis (TM) has an unknown etiology but may be significantly associated with testicular germ cell tumors ...
Margaret H Abel, Ana Monteiro, Guido Verhoeven, Abel, M.H., Verhoeven, G., De Gendt, K., Monteiro, A., Karl De Gendt, O'Shaughnessy, P.J., Peter J O'Shaughnessy, O'Shaughnessy Peter J, Verhoeven Guido, De Gendt Karl, Abel Margaret H, Monteiro Ana   +14 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Sex hormones, obesity and type 2 diabetes: is there a link?

Endocrine Connections, 2019
An imbalance in sex hormones has an important impact on type 2 diabetes (T2DM) mainly through the involvement of visceral adipose tissue. Androgens have an interesting sex-dimorphic association with T2DM, since hyperandrogenism in females and ...
Alessandra Gambineri, Carla Pelusi
doaj   +1 more source

Maternal androgen excess significantly impairs sexual behavior in male and female mouse offspring: Perspective for a biological origin of sexual dysfunction in PCOS

Frontiers in Endocrinology, 2023
IntroductionPolycystic ovary syndrome (PCOS) is the most common infertility disorder worldwide, typically characterised by high circulating androgen levels, oligo- or anovulation, and polycystic ovarian morphology. Sexual dysfunction, including decreased
Nina M. Donaldson, Melanie Prescott, Amy Ruddenklau, Rebecca E. Campbell, Elodie Desroziers   +4 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Evaluating the Term ‘Disorders of Sex Development’: A Multidisciplinary Debate

Social Medicine, 2018
In 2014, almost 10 years after the 2005 International Consensus Conference on Intersex in Chicago, one of the conference co-organisers, under the auspices of a number of international paediatric endocrinology societies, launched the Global DSD Update to ...
Natalie Delimata, Margaret Simmonds, Michelle O’Brien, Georgiann Davis, Richard Auchus, Karen Lin-Su   +5 more
doaj  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Unique targeting of androgen-dependent and -independent AR signaling in prostate cancer to overcome androgen resistance

, 2020
The androgen receptor (AR) is a major driver of prostate cancer (PCa) and a key therapeutic target for AR inhibitors (ie, Enzalutamide). However, Enzalutamide only inhibits androgen-dependent AR signaling, enabling intrinsic AR activation via androgen ...
Lim, Syer C, Kovacevic, Zaklina, Assinder, Stephen J, Maleki, Sanaz, Richardson, Des R, Jansson, Patric J   +5 more
core   +1 more source