Results 81 to 90 of about 333,981 (315)

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer [PDF]

, 2001
Objective To examine the role of androgen receptor (AR) gene amplification and aneusomy of the X chromosome in the development of antiandrogen-resistant prostate cancer.
Bartlett, J.M.S., Edwards, J., Krishna, N.S., Mukherjee, R., Underwood, M.A., Watters, A.D.   +5 more
core   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Analysis of Ratio of Length of 2nd Digit to 4th Digit (2D:4D) among Transgender Women (MtF) and Cisgender People in South Indian Population: A Cross-sectional Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Transgender refers to an individual whose gender identity differs from the sex that was assigned at birth. Transgender women (MtF) were assigned male at birth but later recognised themselves as female. The length of the index finger (2D) in
Karthikeyan Annamalai, Deepti Shastri, Sathiya Subramaniam   +2 more
doaj   +1 more source

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. [PDF]

, 2019
Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to become aggregation-prone.
Banduseela, Varuna C, Brun-Heath, Isabelle, Chiesa, Giulio, Di Sanza, Claudio, Eftekharzadeh, Bahareh, Felli, Isabella C, García, Jesús, Gestwicki, Jason E, Giorgetti, Elisa, Lieberman, Andrew P, Marin-Argany, Marta, Martínez-Cristóbal, Paula, Nath, Samir R, Nebreda, Ángel R, Pierattelli, Roberta, Rauch, Jennifer N, Salvatella, Xavier, Schwarz, Daniel MC, Shao, Hao, Yu, Zhigang   +19 more
core   +2 more sources

Single‐Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re‐Sensitizer Drugs in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
To combat BET inhibitor resistance in triple‐negative breast cancer, we developed two single‐cell computational frameworks. FR20 quantifies resistance by integrating ferroptosis‐related gene signatures, while D‐FR20 screens for potential re‐sensitizers.
Haizhou Liu, Mengqin Yuan, Yini Shang, Jiahao Chen, Fei Hou, Lihong Wang, Wei Jiang   +6 more
wiley   +1 more source

Comparative Study of Anti-Mullerian Hormone and its Correlation with Androgens and Insulin Resistance in Lean and Obese Women with Polycystic Ovary Syndrome

Indian Journal of Endocrinology and Metabolism
Introduction: Anti-Mullerian hormone (AMH) is a key regulator of ovarian folliculogenesis. Obesity, insulin resistance (IR), hyperandrogenism, and gonadotropins have an inconclusive role in the relation and regulation of AMH to polycystic ovarian ...
Sukirti Misra, Jugal V. Gada, Yash V. Chauhan, Sachin S. Rahate, Bhakti D. Karde, Premlata K. Varthakavi, Nikhil M. Bhagwat   +6 more
doaj   +1 more source

Contribution of recent transgenic models and transcriptional profiling studies to our understanding of the mechanisms by which androgens control spermatogenesis [PDF]

, 2008
Publisher ...
Claessens, Frank, De Gendt, Karel, Denolet, Evi, Saunders, Philippa T K, Sharpe, Richard, Swinnen, Johannes V, Verhoeven, Guido, Willems, Ariane   +7 more
core   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

Design, Synthesis and biological evaluation of novel acridine-polyamine conjugates against prostate cancer [PDF]

, 2009
Prostate cancer is the most common cause of cancer death in men, aged 85 and over. Androgen receptor, a single polypeptide with three functional domains is very important during initiation and progression of the disease.
Karodia, N, Maurice, HB, Phillips, Roger
core