The role of androgen and its related signals in PCOS
Journal of Cellular and Molecular Medicine, 2020 Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women at reproductive age. However, the underlying pathogenic mechanisms have not been completely understood. Hyperandrogenism is an important clinic feature in patients with PCOS,
Wenting Ye +3 more
semanticscholar +1 more source
Androgen sensitivity gateway to COVID‐19 disease severity
Drug development research (Print), 2020 In this communication, we present arguments for androgen sensitivity as a likely determinant of COVID‐19 disease severity. The androgen sensitivity model explains why males are more likely to develop severe symptoms while children are ostensibly ...
C. Wambier +7 more
semanticscholar +1 more source
Emerging Mechanisms of Resistance to Androgen Receptor Inhibitors in Prostate Cancer
Nature Reviews. Cancer, 2015 During the past 10 years, preclinical studies implicating sustained androgen receptor (AR) signalling as the primary driver of castration-resistant prostate cancer (CRPC) have led to the development of novel agents targeting the AR pathway that are now ...
Philip A Watson, V. Arora, C. Sawyers
semanticscholar +1 more source
Cardiovascular Effects of Androgen Deprivation Therapy in Prostate Cancer
Arteriosclerosis, Thrombosis and Vascular Biology, 2020 Supplemental Digital Content is available in the text. Androgen deprivation therapy is a cornerstone of prostate cancer treatment. Pharmacological androgen deprivation includes gonadotropin-releasing hormone agonism and antagonism, androgen receptor ...
Jiun-Ruey Hu +8 more
semanticscholar +1 more source
The androgen receptor and signal-transduction pathways in hormone-refractory prostate cancer. Part 1: modifications to the androgen receptor [PDF]
, 2005 Prostate cancer is the second most common male malignancy in the western world an increasing incidence in an ageing population. Treatment of advanced prostate cancer relies on androgen deprivation.
Bakin RE +7 more
core +1 more source
Androgen receptor-dependent and -independent mechanisms driving prostate cancer progression: Opportunities for therapeutic targeting from multiple angles. [PDF]
, 2016 Despite aggressive treatment for localized cancer, prostate cancer (PC) remains a leading cause of cancer-related death for American men due to a subset of patients progressing to lethal and incurable metastatic castrate-resistant prostate cancer (CRPC).
Hoang, David T. +4 more
core +2 more sources
Contribution of recent transgenic models and transcriptional profiling studies to our understanding of the mechanisms by which androgens control spermatogenesis [PDF]
, 2008 Publisher ...
Claessens, Frank +7 more
core +1 more source
Amplification of the androgen receptor may not explain the development of androgen-independent prostate cancer [PDF]
, 2001 Objective To examine the role of androgen receptor (AR) gene amplification and aneusomy of the X chromosome in the development of antiandrogen-resistant prostate cancer.
Bartlett, J.M.S. +5 more
core +1 more source
Role of Androgen Receptor in Prostate Cancer: A Review
The World Journal of Men's Health, 2018 Androgen receptor (AR) is a steroid receptor transcriptional factor for testosterone and dihydrotestosterone consisting of four main domains, the N-terminal domain, DNA-binding domain, hinge region, and ligand-binding domain.
K. Fujita, N. Nonomura
semanticscholar +1 more source
Androgen-independent events in penile development in humans and animals. [PDF]
, 2020 The common view on penile development is that it is androgen-dependent, based first and foremost on the fact that the genital tubercle forms a penis in males and a clitoris in females.
Baskin, Laurence +6 more
core +1 more source