Results 11 to 20 of about 175,765 (268)
Androgen regulation of the androgen receptor coregulators [PDF]
BMC Cancer, 2008 Abstract Background The critical role of the androgen receptor (AR) in the development of prostate cancer is well recognized. The transcriptional activity of AR is partly regulated by coregulatory proteins. It has been suggested that these coregulators could also be important in the progression of prostate cancer. The
Urbanucci, Alfonso +4 more
openaire +4 more sources
Androgens and Androgen Receptor Actions on Bone Health and Disease: From Androgen Deficiency to Androgen Therapy [PDF]
Cells, 2019 Androgens are not only essential for bone development but for the maintenance of bone mass. Therefore, conditions with androgen deficiency, such as male hypogonadism, androgen-insensitive syndromes, and prostate cancer with androgen deprivation therapy are strongly associated with bone loss and increased fracture risk.
Jia-Feng Chen +4 more
openaire +3 more sources
The Roles of Androgen Receptors and Androgen-Binding Proteins in Nongenomic Androgen Actions [PDF]
Molecular Endocrinology, 2002 AbstractThe biological activity of testosterone and dihydrotestosterone is thought to occur predominantly through binding to the androgen receptor (AR), a member of the nuclear receptor superfamily that functions as a ligand-activated transcription factor.
Cynthia A, Heinlein, Chawnshang, Chang
openaire +2 more sources
Role of sex and sex hormones in PD-L1 expression in NSCLC: clinical and therapeutic implications
Frontiers in Oncology, 2023 Currently, immunotherapy based on PD-1/PD-L1 pathway blockade has improved survival of non-small cell lung cancer (NSCLC) patients. However, differential responses have been observed by sex, where men appear to respond better than women.
Vianey Rodriguez-Lara +7 more
doaj +1 more source
Mitogen Activated Protein kinase signal transduction pathways in the prostate
Cell Communication and Signaling, 2004 The biochemistry of the mitogen activated protein kinases ERK, JNK, and p38 have been studied in prostate physiology in an attempt to elucidate novel mechanisms and pathways for the treatment of prostatic disease.
Koul Sweaty +3 more
doaj +1 more source
Journal of Health Science and Medical Research (JHSMR), 2021 Objective: To identify the normal reference ranges of serum testosterone and gonadotropins in Thai fertile men, compare these levels among different age groups, and assess their relationships with body mass index (BMI). Material and Methods: One hundred
Thakorn Pruktanakul +4 more
doaj +1 more source
Frontiers in Endocrinology, 2022 In the 1940s, Alfred Jost demonstrated the necessity of testicular secretions, particularly androgens, for male internal and external genitalia differentiation.
Ciro M. Amato +2 more
doaj +1 more source
A STUDY OF THE ANDROGENIC ACTIVITY OF ANTI-ANDROGEN
Folia Endocrinologica Japonica, 1990 To investigate the androgenic activity of steroidal and nonsteroidal anti-androgens, the effect of several compounds on some parameters as an androgenic activity was measured in the ventral prostate (VP) and seminal vesicle gland (SV) of castrated male rats.
Yamanaka, Hidetoshi +7 more
openaire +3 more sources
Reproductive Medicine and Biology, 2019 Background Polycystic ovary syndrome (PCOS) is a common endocrine disorder among women of reproductive age and a major cause of infertility; however, the pathophysiology of this syndrome is not fully understood.
Satoko Osuka +6 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2022 Dysregulated synaptic plasticity is a key feature of neurodevelopmental disorders, including autism. This study investigated whether Fragile X mental retardation protein (FMRP), a selective RNA-binding protein that regulates synaptic protein expression ...
Huan Chen +29 more
doaj +1 more source