Results 11 to 20 of about 308,877 (93)
The Lancet, 2022 BACKGROUND Current standard of care for metastatic castration-sensitive prostate cancer supplements androgen deprivation therapy with either docetaxel, second-generation hormonal therapy, or radiotherapy.
K. Fizazi +32 more
semanticscholar +1 more source
Androgen receptor activity in T cells limits checkpoint blockade efficacy
Nature, 2022 Immune checkpoint blockade has revolutionized the field of oncology, inducing durable anti-tumour immunity in solid tumours. In patients with advanced prostate cancer, immunotherapy treatments have largely failed1–5.
Xiangnan Guan +14 more
semanticscholar +1 more source
Journal of Healthcare Engineering, 2022 The polycystic ovary syndrome (PCOS) is the disease featured by elevated levels of androgens, ovulatory dysfunction, and morphological abnormalities. At reproductive stage of women, the rate of PCOS occurrence is measured as 6–10% and the prevalence rate
Yalan Xu, J. Qiao
semanticscholar +1 more source
Androgen conspires with the CD8+ T cell exhaustion program and contributes to sex bias in cancer
Science immunology, 2022 Sex bias exists in the development and progression of nonreproductive organ cancers, but the underlying mechanisms are enigmatic. Studies so far have focused largely on sexual dimorphisms in cancer biology and socioeconomic factors.
H. Kwon +20 more
semanticscholar +1 more source
Basics of androgen synthesis and action.
Best practice & research. Clinical endocrinology & metabolism, 2022 Androgens are essential sex steroid hormones for both sexes. Testosterone (T) is the predominant androgen in males, while in adult females, T concentrations are about 15-fold lower and androgen precursors are converted to estrogens.
R. Naamneh Elzenaty +2 more
semanticscholar +1 more source
Androgen Receptor Signaling in Prostate Cancer and Therapeutic Strategies
Cancers, 2021 Simple Summary Early-stage and castration-sensitive prostate cancer (PCa) growth is solely mediated by androgen signaling pathways. AR signaling inhibitors (ARSIs) have significantly improved clinical outcomes among men with PCa.
Aasems Jacob +3 more
semanticscholar +1 more source
Androgen Receptor Signaling Pathway in Prostate Cancer: From Genetics to Clinical Applications
Cells, 2020 Around 80–90% of prostate cancer (PCa) cases are dependent on androgens at initial diagnosis; hence, androgen ablation therapy directed toward a reduction in serum androgens and the inhibition of androgen receptor (AR) is generally the first therapy ...
G. Aurilio +9 more
semanticscholar +1 more source
Androgen insensitivity syndrome.
Baillière's Clinical Endocrinology and Metabolism, 2019 In a relatively short period of time, understanding of the fundamental causes of androgen insensitivity syndromes has improved dramatically. This has been brought about by the combination of several disciplines, including endocrinology, genetics ...
H. Scharnagl +169 more
semanticscholar +1 more source
Definitions, 2020 Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus.
semanticscholar +1 more source
Journal of Clinical Endocrinology and Metabolism, 2010 OBJECTIVE Our objective was to update the guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men published previously in 2006.
S. Bhasin +6 more
semanticscholar +1 more source