Results 31 to 40 of about 308,877 (93)

Negative regulation of the androgen receptor gene through a primate specific androgen response element present in the 5' UTR [PDF]

, 2014
Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
Hay, Colin W, Hunter, Irene, Lavery, Derek N, MacKenzie, Alasdair, McEwan, Iain J, Watt, Kate   +5 more
core   +2 more sources

Salivary testosterone measurement in women with and without polycystic ovary syndrome [PDF]

, 2017
Clinical and/or biochemical hyperandrogenism is one of the diagnostic criteria for PCOS. An evaluation of the role of salivary testosterone (salT) and androstenedione (salA) for the diagnosis of PCOS was undertaken in a cross sectional study involving 65
Adaway, Joanne, Al-Qaissi, Ahmed, Atkin, Stephen, Atkin, Stephen L., Dargham, Soha, Dargham, Soha R., Keevil, Brian, Kilpatrick, Eric, Kilpatrick, Eric S., Sathyapalan, Thozhukat   +9 more
core   +1 more source

Androgen-Induced Immunosuppression

Frontiers in Immunology, 2018
In addition to determining biological sex, sex hormones are known to influence health and disease via regulation of immune cell activities and modulation of target-organ susceptibility to immune-mediated damage.
M. G. Gubbels Bupp, T. Jorgensen
semanticscholar   +1 more source

Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pAR ser81 and CDK1 signaling: biological implications for men treated with testosterone replacement therapy [PDF]

, 2017
Despite the growing body of knowledge showing that testosterone (T) may not significantly affect tumor progression in hypogonadal patients treated for prostate cancer (Pca), the use of this hormone in this population still remains controversial.
Al-Azzawi, Balk, Baniahmad, Buchanan, Christiansen, Christiansen, Denmeade, Dlewati, Festuccia, Festuccia, Festuccia, Gailly, Hayes, Hellstrom, Huang, Isaacs, Isaacs, Isaacs, Isaacs, Jannini, Key, Liu, Maggi, Morgentaler, Morgentaler, Mostaghel, Neidle, Pagano, Pagano, Page, Page, Pandolfi, Park, Paschal, Pestell, Pitha, Roussel, Schneider, Sonnenschein, Soto, Strauss, Swerdloff, Traish, Vogelzang, Wilson, Yen, Zi   +46 more
core   +1 more source

The gut microbiota is a major regulator of androgen metabolism in intestinal contents

American Journal of Physiology. Endocrinology and Metabolism, 2019
Androgens exert important effects both in androgen-responsive tissues and in the intestinal tract. To determine the impact of the gut microbiota (GM) on intestinal androgen metabolism, we measured unconjugated (free) and glucuronidated androgen levels in
Hannah Colldén, A. Landin, V. Wallenius, Erik Elebring, L. Fändriks, Maria E. Nilsson, Henrik Ryberg, M. Poutanen, K. Sjögren, L. Vandenput, C. Ohlsson   +10 more
semanticscholar   +1 more source

International study into the use of intermittent hormone therapy in the treatment of carcinoma of the prostate : A meta-analysis of 1446 patients [PDF]

, 2007
OBJECTIVE: To review pooled phase II data to identify features of different regimens of intermittent hormone therapy (IHT), developed to reduce the morbidity of treating metastatic prostate cancer, and which carries a theoretical advantage of delaying ...
Cuzick, Jack, Goldenberg, S. Larry, Oliver, Tim, Prowse, David M., Shaw, Greg L., Spry, Nigel A., Wilson, Peter   +6 more
core   +1 more source

Androgen Receptor Signaling in the Development of Castration-Resistant Prostate Cancer

Frontiers in Oncology, 2019
Most prostate cancers are androgen-sensitive malignancies whose growths depend on the transcriptional activity of the androgen receptor (AR). In the 1940s, Charles Huggins demonstrated that the surgical removal of testes in men can result in a dramatic ...
Qin Feng, B. He
semanticscholar   +1 more source

Towards Personalized Prostate Cancer Therapy Using Delta-Reachability Analysis [PDF]

, 2015
Recent clinical studies suggest that the efficacy of hormone therapy for prostate cancer depends on the characteristics of individual patients. In this paper, we develop a computational framework for identifying patient-specific androgen ablation therapy
Biere A., Bogomolov S., Bruchovsky N., Chen X., Cimatti A., Frehse G., Gao S., Palaniappan S. K.   +7 more
core   +1 more source

Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance

Communications Biology, 2018
The androgen receptor is a major driver of prostate cancer and inhibition of its transcriptional activity using competitive antagonists, such as enzalutamide remains a frontline therapy for prostate cancer management.
J. Salami, Shanique Alabi, Ryan R Willard, N. Vitale, Jing Wang, Hanqing Dong, Meizhong Jin, D. McDonnell, A. Crew, T. Neklesa, C. Crews   +10 more
semanticscholar   +1 more source

Androgen receptor phosphorylation status at serine 578 predicts poor outcome in prostate cancer patients [PDF]

, 2016
Purpose: Prostate cancer growth is dependent upon androgen receptor (AR) activation, regulated via phosphorylation. Protein kinase C (PKC) is one kinase that can mediate AR phosphorylation. This study aimed to establish if AR phosphorylation by PKC is of
Edwards, J., Heng, J.S., Horgan, P.G., Leung, H.Y., Patek, S.C., Taylor, B., Underwood, M.A., Willder, J.M.   +7 more
core   +1 more source