Results 141 to 150 of about 175,765 (268)

Knockdown of CREB3L4 Inhibits Autophagy and Reduces Cisplatin Resistance in Gastric Cancer Cells by Downregulating BAG3

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Cisplatin resistance remains a major obstacle in the treatment of gastric cancer (GC), and autophagy has been increasingly recognized as a key cytoprotective mechanism contributing to chemoresistance. CREB3L4 is an endoplasmic reticulum membrane‐bound transcription factor that has been shown to regulate the expression of Bcl‐2 associated ...
Wen‐Ke Yin   +3 more
wiley   +1 more source

Peri‐ and Post‐Menopausal Hormone Replacement Therapy and Voice Disorder Risk: A TriNetX Study

open access: yesThe Laryngoscope, EarlyView.
ABSTRACT Objectives The aim of this study was to elucidate the risk of developing voice disorders among peri‐ and post‐menopausal female hormone replacement therapy (HRT) users. Methods A retrospective cohort study was conducted using the TriNetX Global Collaborative Network.
David Kayekjian   +4 more
wiley   +1 more source

The Natural History of Residual and Recurrent Disease in Advanced Juvenile Nasopharyngeal Angiofibroma: A Systematic Review

open access: yesThe Laryngoscope, EarlyView.
Residual and recurrent disease in advanced juvenile nasopharyngeal angiofibromas (JNAs) demonstrate spontaneous involution, reduction in size, or long‐term stability following initial treatment in 95% of patients. In this systematic review of 131 patients with advanced JNA, only 2% of patients demonstrated disease progression during surveillance, but ...
Shivani Angelique Kumar   +2 more
wiley   +1 more source

Exocrine Gland Dysfunction in Parkinson's Disease: Pathophysiology, Clinical Manifestations, and Therapeutic Perspectives—A Narrative Review

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Non‐motor symptoms, especially autonomic dysfunction, are major contributors to disability and decreased quality of life in Parkinson's disease (PD). Despite being common and having a wide range of clinical facets, exocrine gland dysfunction is still not well recognized and managed.
Renato P. Munhoz   +2 more
wiley   +1 more source

Genetic Characterization and Multidisciplinary Management of Complete Androgen Insensitivity Syndrome: Unveiling a Novel AR Mutation. [PDF]

open access: yesClin Case Rep
Francesca AM   +10 more
europepmc   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek   +3 more
wiley   +1 more source

Basal androgen status as a modifiable predictor of poor ovarian response in controlled ovarian hyperstimulation. [PDF]

open access: yesFront Reprod Health
Münch ML   +9 more
europepmc   +1 more source

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