Results 171 to 180 of about 175,765 (268)

Salvage Androgen Deprivation Therapy Use After Definitive Radiotherapy With vs Without Androgen Deprivation Therapy in Prostate Cancer

The Prostate, EarlyView.
ABSTRACT Background For patients with unfavorable intermediate or high risk localized prostate cancer receiving definitive radiotherapy, androgen deprivation therapy reduces recurrence and improves survival but is underutilized due to toxicity concerns. Patients who forgo initial ADT may later require salvage ADT.
Jiaye Shen, Aaron J. Katz, Yahui Xie, Ronald C. Chen, Mutlay Sayan   +4 more
wiley   +1 more source

Clinical Impact of Gleason Pattern 5 on Doublet Versus Triplet Therapy in Metastatic Hormone‐Sensitive Prostate Cancer

The Prostate, EarlyView.
ABSTRACT Background Upfront treatment intensification with androgen deprivation therapy (ADT) plus an androgen receptor pathway inhibitor has become a standard approach for metastatic hormone‐sensitive prostate cancer (mHSPC). However, prognosis remains poor for some patients despite second‐generation androgen receptor antagonist‐based doublet therapy.
Saizo Fujimoto, Tsuyoshi Morita, Yutaka Yamamoto, Teruo Inamoto, Keita Tamura, Yuki Yoshikawa, Ryoichi Maenosono, Akihito Takeuchi, Kiyoshi Takahara, Seitetsu Sugiyama, Kazumasa Komura, Takafumi Yanagisawa, Wataru Fukuokaya, Takahiro Kimura, Kazutoshi Fujita   +14 more
wiley   +1 more source

Metformin improves endotoxemia and alters folliculogenesis in women with polycystic ovary syndrome. [PDF]

Endocr Connect
Trzcinski M, Chudzicka-Strugala I, Kim K, Piekarski P, Spaczynski R, Zwoździak B, Banaszewska B, Pawelczyk L, Chang RJ, Duleba AJ.   +9 more
europepmc   +1 more source

Management of De Novo miN1 Prostate Cancer in the PSMA‐PET Era

The Prostate, EarlyView.
ABSTRACT Background Prostate‐specific membrane antigen positron emission tomography (PSMA‐PET) is reshaping nodal staging in prostate cancer by detecting regional lymph node metastases with greater accuracy than conventional imaging. This has created a new cohort of patients with N1M0 disease detectable only on advanced imaging, raising important ...
Thomas McMaster, Caitlin Ying Ming Louey, Jordan Santucci, Chloe Hobson, David D. Chen, Niranjan Sathianathen, Joseph Ischia, Damien M. Bolton, Nathan Lawrentschuck, Declan G. Murphy, Shankar Siva, Marlon Perera   +11 more
wiley   +1 more source

PSA Response as a Prognostic Marker in Metastatic Hormone-sensitive Prostate Cancer: Comparison with Tumor Volume (CHAARTED). [PDF]

Eur Urol Open Sci
Martínez-Corral R, Pablos-Rodríguez P, Antón-Fuente S, Bardella-Altarriba C, Díaz-Pedrouzo A, Abuin-García J, Vera-Ballesteros FJ, Abella-Serra A, Martínez-Corral ME, Gómez-Ferrer A, Picola-Brau N, Martínez-Breijo S, Costa-Planells M, López-Abad A, García-Puche M, Pérez-Fentes D.   +15 more
europepmc   +1 more source

A sample size analysis of a mathematical model of longitudinal tumor volume and progression‐free survival for Bayesian individual dynamic predictions in recurrent high‐grade glioma

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 495-509, March 2025.
Abstract Patients with recurrent high‐grade glioma (rHGG) have a poor prognosis with median progression‐free survival (PFS) of <7 months. Responses to treatment are heterogenous, suggesting a clinical need for prognostic models. Bayesian data analysis can exploit individual patient follow‐up imaging studies to adaptively predict the risk of progression.
Daniel J. Glazar, Solmaz Sahebjam, Hsiang‐Husan M. Yu, Dung‐Tsa Chen, Menal Bhandari, Heiko Enderling   +5 more
wiley   +1 more source

Nocturnal awakening secondary to pain in sleep‐related painful erection: A case report and literature review

Sleep Research, EarlyView.
Abstract A 41‐year‐old male patient presented with a 13‐year history of recurrent nocturnal penile pain associated with erections during sleep. Over the course of his illness, the patient attended outpatient clinics on 298 occasions and was hospitalized three times. The primary symptom reported was erectile pain occurring during sleep.
Liping Zhang, Jinxiang Cheng, Jiaxiu He, Rui Guo, Changjun Su, Xianchao Zhao   +5 more
wiley   +1 more source

Castration-induced nigrostriatal deficits are linked to reduced TrkB and loss of mature spines in the dorsal striatum. [PDF]

Front Endocrinol (Lausanne)
Donahue GJ, Lundari JA, Kane PW, Matamorose-Patrick SM, Klotz JE, Carr NL, Kudriavetz SC, Brague JC.   +7 more
europepmc   +1 more source

EE2 and the Fish Brain: Age‐Dependent Impact of 17α‐Ethinylestradiol on Brain Cell Proliferation and Behavior in Sea Bass Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Endocrine‐disrupting chemicals (EDCs), such as 17α‐ethinylestradiol (EE2), have raised concerns about their potential effects on aquatic organisms, particularly during early developmental stages. In this context, the study of behavioral disruption has gained considerable attention, as it may have consequences on individual fitness and ...
Soloperto Sofia, Stephanie Olivier, Céline Thomasse, Christophe Minier, Marie‐Pierre Halm‐Lemeille, Christelle Jozet‐Alves, Salima Aroua   +6 more
wiley   +1 more source

Synergistic Toxicity of Low‐Concentration Metal Mixture on Male Rats: Reproductive, Renal, and Hepatic Effects

Environmental Toxicology, EarlyView.
ABSTRACT Mining plays a crucial role in economic development, but improper management can lead to severe environmental degradation. Particularly for iron ore, mining generates vast amounts of tailings often stored in unstable dams. This study aims to investigate the toxicological impacts of environmentally relevant concentrations of metals mixture ...
Kalinka Helóra Gomes de Almeida, Thalita Tofanin Sargiani D'Assumpção, Ana Priscila Gomes Silva, Carolina Rocha Moreira de Oliveira, Tailisi Hoppe Trevizani, Rubens Cesar Lopes Figueira, Lucas Buruaem Moreira, Juliana Elaine Perobelli   +7 more
wiley   +1 more source