Results 271 to 280 of about 389,574 (340)

Sex Differences in Response and Persistence to Biologic Therapy in Psoriatic Arthritis: A 52‐Week Analysis With Extended Long‐Term Outcomes

The Journal of Dermatology, EarlyView.
ABSTRACT Psoriatic arthritis (PsA) is a chronic immune‐mediated disease with heterogeneous joint and skin manifestations. Although biologic therapies targeting TNFα, IL‐17, and IL‐23 have transformed PsA management, sex‐specific differences in efficacy and treatment persistence remain underexplored.
Keita Ohyachi, Saori Takamura, Kanade Iino, Souichiro Saito, Mizuki Takeuchi, Tomoo Fukuda   +5 more
wiley   +1 more source

Differential Androgen Receptor Expression Across Bladder Cancer Stages and Its Link to Poor Outcomes. [PDF]

Cancers (Basel)
Plage H, Biernath N, Furlano K, Weinberger S, Jeutner J, Fendler A, Roßner F, Schallenberg S, Elezkurtaj S, Kluth M, Lennartz M, Marx AH, Samtleben H, Fisch M, Rink M, Slojewski M, Kaczmarek K, Koch S, Adamini N, Minner S, Simon R, Sauter G, Zecha H, Ecke T, Schlomm T, Horst D, Ralla B.   +26 more
europepmc   +1 more source

Advent of NK3R Antagonists for the Treatment of Menopausal Hot Flushes: A Narrative Review

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT The menopause transition is marked by symptoms predominantly attributed to declining oestrogen levels. Approximately 80% of women experience associated symptoms, and 25% experience severe symptoms. The commonest are vasomotor symptoms (VMS), collectively referring to hot flushes and/or night sweats.
Aaran H. Patel, Aureliane Pierret, Edouard G. Mills, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Clonal selection of pre-existing neuroendocrine component in prostate cancer during androgen receptor signaling inhibitor therapy: A case report. [PDF]

Urol Case Rep
Kubota H, Kijima T, Matsuda H, Uematsu T, Takei K, Yashi M, Ishida K, Kamai T.   +7 more
europepmc   +1 more source

Sexual Function, Activity and Distress 24 Months After Surgical Menopause: What Happens After Menopause (WHAM)—A Prospective Controlled Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To determine the effect of surgical menopause (risk‐reducing salpingo‐oophorectomy, RRSO) on sexual function and the modifying effects of HRT. Design Prospective observational study of women undergoing RRSO and age‐matched comparison group who retained their ovaries. Setting High‐risk clinics and general population.
Martha Hickey, Trevor Tejada‐Berges, Susan M. Domchek, Efrosinia O. Krejany, Alison Brand, Peixuan Li, Sabine Braat, Sheryl Kingsberg   +7 more
wiley   +1 more source

Fetal Ovarian Cyst Associated With Disorders of Sex Development: A Case Report. [PDF]

Cureus
Rosado-Guzmán AS, Escobedo-Enríquez ZV, Arellano-Llamas AA, Sánchez Balpuesta OR, Pérez-Lemus CN.   +4 more
europepmc   +1 more source

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, EarlyView.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source

Connection between granulosa cell pyroptosis and oocyte endoplasmic reticulum stress in a mouse model of polycystic ovary syndrome. [PDF]

J Ovarian Res
Zhang Y, Xie X, Han L.
europepmc   +1 more source

Luteinizing hormone receptor knockout mouse: What has it taught us?

Andrology, EarlyView.
Abstract Luteinizing hormone (LH), along with its agonist choriongonadotropin (hCG) in humans, is the key hormone responsible for the tropic regulation of the gonadal function. LH and hCG act through their cognate receptor, the luteinizing hormone/choriongonadotropin receptor (LHCGR; more appropriately LHR in rodents lacking CG), located in the testis ...
Ilpo T. Huhtaniemi
wiley   +1 more source