Results 201 to 210 of about 20,010 (263)

Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study

Cancer Science, EarlyView.
In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota, Taku Naiki, Koji Hatano, Akira Yokomizo, Hiroaki Tsuchiya, Yoko Takahashi, Taku Nakayama, Masaki Yoshida, Hirotsugu Uemura   +8 more
wiley   +1 more source

Impact of the Nadir Androgen Receptor Signaling Inhibitor-Derived Integrative Response Model in Real-World Patients With Metastatic Castration-Sensitive Prostate Cancer. [PDF]

Prostate
Yukihiro K, Sekino Y, Goto K, Saito K, Fujiyama K, Kagiyama Y, Kurimura Y, Fukuoka K, Naito M, Miyamoto S, Kobatake K, Kitano H, Goriki A, Hieda K, Hinata N.   +14 more
europepmc   +1 more source

O‐GlcNAcylation of KAT2A Enhances Bladder Cancer Proliferation by Inhibiting the KAT2A‐TRIM22 Interaction

Cancer Science, EarlyView.
Lysine acetyltransferase 2A (KAT2A) is a transcriptional coactivator and a member of the Histone Acetyltransferase (HAT) family. While altered KAT2A activity has been implicated in various cancers, its role in bladder cancer (BLCA) remains poorly understood.
Wenjie Yang, Zhaoheng Jin, Ziyi Li, Weifeng Xu, Yingjie Li, Yueqiang Peng, Jie Dong, Lin Ma, Zhigang Ji   +8 more
wiley   +1 more source

The efficacy and safety of darolutamide combination therapy in advanced prostate cancer: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Front Pharmacol
Cao X, Li D, Han Z, Li Z, Chu J, Song C, Huang H, Yuan H, Wang Z.   +8 more
europepmc   +1 more source

Cardiometabolic Risk in First Degree Relatives of Women With Polycystic Ovary Syndrome (PCOS)

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a common multisystem disorder with reproductive, cardiometabolic and psychological implications. Genetic factors play a role in the pathogenesis of PCOS. We sought to investigate the cardiometabolic health of first degree relatives (FDR) of women with PCOS.
Su Jen Chua, Xinyi Wu, Tahani Al Kindi, Bulent O. Yildiz, Aya Mousa, Loyal Pattuwage, Helena Teede, Anju E. Joham, Chau Thien Tay   +8 more
wiley   +1 more source

PTEN: Regulation, Signalling and Targeting in Cancer. [PDF]

Cancers (Basel)
Kotelevets L, Scott MGH, Chastre E.
europepmc   +1 more source

The Relationship Between Polycystic Ovary Syndrome (PCOS) and Depression

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder, frequently accompanied by psychological comorbidities including depression. The aim of this narrative review is to summarise the latest research regarding potential contributors to and underpinning mechanisms of this relationship.
Asimina I. Karampela, Maralyn Druce
wiley   +1 more source

What is the need for adrenalectomy in patients with congenital adrenal hyperplasia in the era of CRF1/ACTH inhibitors? [PDF]

Front Endocrinol (Lausanne)
Fedorova O, Falhammar H.
europepmc   +1 more source

Hypoxia-Driven Mechanisms of Drug Resistance in Prostate Cancer. [PDF]

Cancers (Basel)
Ressel MR, Flores CE, Warfel NA.
europepmc   +1 more source

Alliance A222001: Oxybutynin Versus Placebo for the Treatment of Hot Flashes in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer. [PDF]

J Clin Oncol
Stish BJ, Mazza GL, Nauseef JT, Humeniuk MS, Smith TJ, Tofthagen C, Diaz Pardo DA, Chay C, Huang AJ, Naha K, Tagawa ST, Chow S, Ruddy KJ, Lustberg MB, Adams-Campbell LL, Novotny PJ, Loprinzi CL.   +16 more
europepmc   +1 more source