Results 301 to 310 of about 141,437 (356)
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Annales d'Endocrinologie, 2022
Male infertility contributes to 50% of all cases of infertility. The main cause is low quality and quantity of sperm. In humans, spermatogenesis starts at the beginning of puberty and lasts lifelong. It is under the control of FSH and testicular androgens, and mainly testosterone (T), and therefore requires a normal gonadotroph axis, intratesticular T ...
Sophie, Christin-Maitre, Jacques, Young
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Male infertility contributes to 50% of all cases of infertility. The main cause is low quality and quantity of sperm. In humans, spermatogenesis starts at the beginning of puberty and lasts lifelong. It is under the control of FSH and testicular androgens, and mainly testosterone (T), and therefore requires a normal gonadotroph axis, intratesticular T ...
Sophie, Christin-Maitre, Jacques, Young
openaire +2 more sources
Androgens, Antiandrogens and Androgen Receptor Abnormalities
European Urology, 1996Information on the molecular structure of the human androgen receptor has increased insight into the molecular mechanism of action of androgens and antiandrogens. It has also facilitated the study of molecular defects in the androgen receptor gene associated with prostate cancer.
C W, Kuil, A O, Brinkmann
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Androgen antagonists in androgen target tissues
Pharmacology & Therapeutics, 1984Most antiandrogens appear to act by binding to the androgen receptor and competitively inhibiting the binding of testosterone and cihydrotestosterone to the receptor. Focusing on those compounds which appear to inhibit androgen receptor mediated responses this review discusses the chemistry of those antiandrogens which have been studied to the extent ...
D J, Tindall +3 more
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2016
Androgen abuse is the most potent and prevalent form of sports doping detected. It originated from the early years of the Cold War as an epidemic confined to drug cheating within elite power sports. In the decades following the end of the Cold War, it has become disseminated into an endemic based within the illicit drug subcultures serving recreational
Rakesh Iyer, David J. Handelsman
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Androgen abuse is the most potent and prevalent form of sports doping detected. It originated from the early years of the Cold War as an epidemic confined to drug cheating within elite power sports. In the decades following the end of the Cold War, it has become disseminated into an endemic based within the illicit drug subcultures serving recreational
Rakesh Iyer, David J. Handelsman
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Androgens, Anabolic-Androgenic Steroids, and Inhibitors
American Journal of Therapeutics, 2000Androgens are steroid hormones responsible for male sexual characteristics, testosterone being the principal androgen secreted by the testes. Androgens have both masculinizing and growth-stimulating or anabolic effects. Synthetic analogs of androgens have been used by professional, as well as amateur, athletes for possible performance enhancement.
J L, Donahue, D T, Lowenthal
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Endocrinology, 1981
Tritiated dihydrotestosterone ([3H]DHT) binds with high affinity to a single class of limited capacity sites in cytoplasmic preparations from rat and mouse thymus glands. The affinity of these bindings sites for [3H]DHT (Kd at 4 C, 1 nM) and their specificity [methyltrienolone (R1881) greater than DHT greater than testosterone much greater than ...
P, Pearce, B A, Khalid, J W, Funder
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Tritiated dihydrotestosterone ([3H]DHT) binds with high affinity to a single class of limited capacity sites in cytoplasmic preparations from rat and mouse thymus glands. The affinity of these bindings sites for [3H]DHT (Kd at 4 C, 1 nM) and their specificity [methyltrienolone (R1881) greater than DHT greater than testosterone much greater than ...
P, Pearce, B A, Khalid, J W, Funder
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Molecular and Cellular Endocrinology, 2002
Growth, adolescent sexual development and changes in body composition are described in male adolescents. The underlying changes in the hypothalamic-pituitary gonadal and the GH/IGF-I axes that underline the physical changes are then described. Finally, how high energy output, at a time of low energy input, using, as an example, scholastic male ...
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Growth, adolescent sexual development and changes in body composition are described in male adolescents. The underlying changes in the hypothalamic-pituitary gonadal and the GH/IGF-I axes that underline the physical changes are then described. Finally, how high energy output, at a time of low energy input, using, as an example, scholastic male ...
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Androgen receptor mutations and androgen insensitivity
Molecular and Cellular Endocrinology, 2002The androgen receptor (AR) is a high affinity receptor protein encoded on the human X-chromosome that mediates the actions of androgens during development and in the adult. Defects in this receptor protein result in a wide range of abnormalities of male sexual development.
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American Journal of Medical Genetics, 1999
The androgen receptor (AR) protein regulates transcription of certain genes. Usually, this activity depends upon a central DNA-binding domain that permits the binding of androgen-AR complexes to regulatory DNA sequences near or in a target gene. The AR also has a C-terminal androgen-binding domain (ABD) and an N-terminal modulatory domain.
B, Gottlieb +3 more
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The androgen receptor (AR) protein regulates transcription of certain genes. Usually, this activity depends upon a central DNA-binding domain that permits the binding of androgen-AR complexes to regulatory DNA sequences near or in a target gene. The AR also has a C-terminal androgen-binding domain (ABD) and an N-terminal modulatory domain.
B, Gottlieb +3 more
openaire +2 more sources