Results 71 to 80 of about 5,820 (221)
Phytotherapy Research, Volume 40, Issue 6, Page 3171-3189, June 2026.Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou +9 more
wiley +1 more source
Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.ABSTRACT Background Hyperpigmentation disorders are a distressing condition, especially for individuals with skin of color who are at higher risk. Often treated topically, a significant advancement in this field was Kligman's depigmenting trio, inhibiting melanogenesis, providing anti‐inflammatory benefits, and promoting epidermal renewal.
Susanna Margaretha H. Kannenberg +9 more
wiley +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie +7 more
wiley +1 more source
Cytotoxic Potential of Andrographolide against Bovine Tuberculosis
, 2018 Bovine tuberculosis is a chronic mycobacterial infection that impinges on a wide range of mammals, including man, cattle, deer, pigs and carnivores.
HK Garg (5238494) +1 more
core +1 more source
Bioavailability Studies Of Andrographolide In Rats [PDF]
, 2016 Satu kaedah analisis kromatografi cecair prestasi tinggi yang mudah, sensitif and khusus telah dibangunkan dan disahkan untuk pengesanan dan kuantifikasi andrographolide di dalam plasma. Kaedah ini adalah linear dari 31.3ng/mL hingga 2000ng/mL.
Chia, Lee Huang
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Cytotoxic Potential of Andrographolide against Bovine Tuberculosis
, 2013 Bovine tuberculosis is a chronic mycobacterial infection that impinges on a wide range of mammals, including man, cattle, deer, pigs and carnivores.
Ashish Shrivastava, Dr HK Garg
core +1 more source
Frontiers in PharmacologyUlcerative colitis (UC) is a recurring inflammatory bowel disease, in which oxidative stress plays a role in its progression, and regulation of the oxidative/antioxidative balance has been suggested as a potential target for the treatment of UC.
Long Shu +12 more
doaj +1 more source
Advanced Science, Volume 13, Issue 20, 9 April 2026.Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin +12 more
wiley +1 more source
Diterpenoid Diversity across Land Plants
Helvetica Chimica Acta, Volume 109, Issue 4, April 2026.Here we bridge the knowledge of diterpene chemical diversity, biosynthesis, and evolution from nonvascular mosses and liverworts to that known from vascular plants. ABSTRACT The diverse array of diterpenoid natural products stems from the ease of manipulating the promiscuity of diterpene cyclases.
Anita Berg +2 more
wiley +1 more source
Genotoxicity assessment of andrographolide. [PDF]
, 2008 In this thesis, the genotoxic potential of andrographolide, which is a primary phytochemical of an annual herb Andrographis paniculata, was assessed and the possible mechanisms of action were elucidated.
Yusrizam Sharifuddin
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